1. Articles from Marcel Kraft

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    1. Optical detection of cancer and precancerous lesions of the upper aerodigestive tract: methods for assessment of vertical extensions

      Optical detection of cancer and precancerous lesions of the upper aerodigestive tract: methods for assessment of vertical extensions

      Introduction: Endoscopic imaging can be used in the assessment of cancer and precancerous lesions of the upper aerodigestive tract. The objective of this presentation is to describe vertical imaging methods. Methods: The working principle and technique of optical coherence tomography (OCT) as well as endosonography (EUS) are briefly illustrated. Results: The main indications, normal and pathologic findings of each method, frequent pitfalls, and clinical results up to now are presented in detail. Conclusions: Endosonography helps in determining the exact extension of advanced carcinomas beyond 3 mm, while OCT, due to its better resolution, is superior in the assessment of precancerous ...

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    2. Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

      Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

      Background This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT). Methods An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an “unblinded” investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 “blinded” investigators. Forty-eight images underwent retrospective image analysis. Results Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the ...

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      Mentions: Herbert Stepp
    3. Measurement of epithelial thickness within the oral cavity using optical coherence tomography

      Measurement of epithelial thickness within the oral cavity using optical coherence tomography

      Background The purpose of the present study was to determine normal values of epithelial thickness within the oral cavity by using optical coherence tomography (OCT). MethodsIn a total of 143 healthy test persons, epithelial thickness of the oral mucosa was determined with the help of OCT separately for each side at 7 different locations. Special attention was directed to those sites having the highest incidence for the development of dysplasias and carcinomas.ResultsThe epithelium demonstrated a varying thickness depending on its location within the oral cavity. The highest values were found in the region of the buccal mucosa (294 μm ...

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    4. Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)

      Measurement of epithelial thickness within the oral cavity using optical coherence tomography (OCT)
      Optical coherence tomography (OCT) is a promising method in the early diagnosis of oral cavity cancer. The objective of the present study is to determine normal values of epithelial thickness in the oral cavity, as no such data are to be found in the literature. In healthy test persons, epithelial thickness of the oral mucosa was determined with the help of OCT separately for each side at nine different locations. Special attention was directed to those sites having the highest incidence for the development of dysplasias and carcinomas. Depending on the location within the oral cavity, the epithelium demonstrated a ...
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    5. Optical and molecular techniques to identify tumor margins within the larynx

      Optical and molecular techniques to identify tumor margins within the larynx
      Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ...
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    6. Clinical value of optical coherence tomography in laryngology

      Background. Optical coherence tomography (OCT) is a new, noninvasive imaging technology for the evaluation of superficial lesions. The objective of this study is to evaluate microlaryngoscopy in combination with OCT compared with microlaryngoscopy alone (ie, without OCT) in supplying a specific diagnosis, predicting invasive tumor growth and epithelial dysplasia in the larynx. Methods. This was a prospective study including 217 laryngeal lesions in a total of 193 patients undergoing surgery. Intraoperative suspicion diagnosis gained by microlaryngoscopy with and without OCT was compared with conventional histopathology after excisional biopsy. Results. Microlaryngoscopy with OCT supplied a specific diagnosis in 89% of cases ...
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    7. Significance of optical coherence tomography in the assessment of laryngeal lesions

      Optical coherence tomography (OCT) is a new promising imaging modality in laryngology as yet of undetermined value. The objective of the present study was to evaluate the ability of this noninvasive method to make a reliable prediction of diagnosis in laryngeal disease. In a prospective study, 225 b ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421O (2008)] published Fri Feb 8, 2008.
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    1-7 of 7
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  2. Topics in the News

    1. (2 articles) Laser Zentrum Hannover
    2. (2 articles) Ludwig Maximilian University of Munich
    3. (2 articles) Holger Lubatschowski
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    5. (1 articles) Gloucestershire Royal Hospital
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