1. Articles from Michael Leitner

    1-19 of 19
    1. Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Thorlabs Extends OCT Offering to Include 248 kHz A-Scan Rate Systems

      Thorlabs announced today that it has expanded its well-established Ganymede™ OCT line to include two complete imaging systems offering an industry-leading A-scan rate of 248 kHz. With this new release, the GAN610C1 and GAN620C1 become the fastest commercially available Spectral-Domain OCT systems on the market, providing a new standard for high-speed, high-sensitivity 2D and 3D imaging of moving samples with reduced motion artifacts. As with Thorlabs’ previously released Ganymede™ and Telesto™ OCT systems, these new OCT systems are available in both general-purpose (GAN610) and high-resolution (GAN620 – 3 µm axial resolution) variants, each of which offers the same low roll-off and ...

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    2. Application Engineer in Optical Coherence Tomography at Thorlabs Lubeck Germany

      Application Engineer in Optical Coherence Tomography at Thorlabs Lubeck Germany

      We are a world-leading manufacturer of photonics tools and systems and our products range from optics and opto-mechanical positioning components to sophisticated optical imaging systems. Our customer basis covers renowned research and development centers and industrial manufacturers from the biotechnology, medical devices, and automation fields. At the Thorlabs facilities in Luebeck, Germany, we develop and manufacture OCT (optical coherence tomography) systems for volumetric imaging. Due to our constant growth we are searching for an Application engineer (m/f) Optical Coherence Tomography Essential job functions include the following, but are not limited to Provide guidance for customers regarding the applicability and ...

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    3. In-Line Monitoring of a Pharmaceutical Pan Coating Process by Optical Coherence Tomography

      In-Line Monitoring of a Pharmaceutical Pan Coating Process by Optical Coherence Tomography

      This work demonstrates a new in-line measurement technique for monitoring the coating growth of randomly moving tablets in a pan coating process. In-line quality control is performed by an optical coherence tomography (OCT) sensor allowing nondestructive and contact-free acquisition of cross-section images of film coatings in real time. The coating thickness can be determined directly from these OCT images and no chemometric calibration models are required for quantification. Coating thickness measurements are extracted from the images by a fully automated algorithm. Results of the in-line measurements are validated using off-line OCT images, thickness calculations from tablet dimension measurements, and weight ...

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    4. Automated pharmaceutical tablet coating layer evaluation of optical coherence tomography images

      Automated pharmaceutical tablet coating layer evaluation of optical coherence tomography images

      Film coating of pharmaceutical tablets is often applied to influence the drug release behaviour. The coating characteristics such as thickness and uniformity are critical quality parameters, which need to be precisely controlled. Optical coherence tomography (OCT) shows not only high potential for off-line quality control of film-coated tablets but also for in-line monitoring of coating processes. However, an in-line quality control tool must be able to determine coating thickness measurements automatically and in real-time. This study proposes an automatic thickness evaluation algorithm for bi-convex tables, which provides about 1000 thickness measurements within 1 s. Beside the segmentation of the coating ...

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    5. Accurate and automated image segmentation of 3D optical coherence tomography data suffering from low signal-to-noise levels

      Accurate and automated image segmentation of 3D optical coherence tomography data suffering from low signal-to-noise levels

      Optical coherence tomography (OCT) has proven to be a useful tool for investigating internal structures in ceramic tapes, and the technique is expected to be important for roll-to-roll manufacturing. However, because of high scattering in ceramic materials, noise and speckles deteriorate the image quality, which makes automated quantitative measurements of internal interfaces difficult. To overcome this difficulty we present in this paper an innovative image analysis approach based on volumetric OCT data. The engine in the analysis is a 3D image processing and analysis algorithm. It is dedicated to boundary segmentation and dimensional measurement in volumetric OCT images, and offers ...

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    6. Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

      Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

      The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor providing cross-section images. Through the OCT measurements, the coating thickness could be determined directly, without a chemometric calibration model required for the quantification. The direct integration of the OCT sensor head into the fluid-bed systems allowed continuous monitoring of the coating growth. Moreover, the in-line investigation of the intra- and inter-pellet coating uniformity was possible due to OCT's high acquisition rate ...

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    7. Real-time data processing for in-line monitoring of a pharmaceutical coating process by optical coherence tomography

      Real-time data processing for in-line monitoring of a pharmaceutical coating process by optical coherence tomography

      Coating of tablets is a widely applied unit operation in the pharmaceutical industry. Thickness and uniformity of the coating layer are crucial for efficacy as well as for compliance. Not only due to different initiatives it is thus essential to monitor and control the coating process in-line. Optical coherence tomography (OCT) was already shown in previous works to be a suitable candidate for in-line monitoring of coating processes. However, to utilize the full potential of the OCT technology an automatic evaluation of the OCT measurements is essential. The automatic evaluation is currently implemented in MATLAB and includes several steps: (1 ...

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    8. Apparatus and method of monitoring and measurement using spectral low coherence interferometry

      Apparatus and method of monitoring and measurement using spectral low coherence interferometry

      A spectral interferometry apparatus and method are disclosed, that can be used to monitor or measure an unknown length by following a characteristic of an indicating signal. The measurement is performed by adjusting an optical path difference (OPD) in an interferometer part of an interferometer configuration until sound or light or both are obtained with the desired strength and pitch. Embodiments are presented where the unknown length is the eye length. Spectral interrogation of the interferometer optical output is achieved by reading the signal of an analogue photodetector array in a spectrometer or by tuning a swept source and processing ...

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    9. Optical Coherence Tomography as a Novel Tool for In-Line Monitoring of a Pharmaceutical Film-Coating Process

      Optical Coherence Tomography as a Novel Tool for In-Line Monitoring of a Pharmaceutical Film-Coating Process

      Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT images of several commercially-available film-coated tablets of different shapes, formulations and coating thicknesses were captured off-line using two OCT systems with centre wavelengths of 830 nm and 1325 nm. Based on the off-line image evaluation, another OCT system operating at a shorter wavelength was selected to study the feasibility of OCT as an in-line monitoring method. Since in spectral-domain OCT motion artefacts can occur as ...

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    10. Feature Of The Week 9/8/13: Austrian Researchers Investigate OCT for Analysis of Coatings in Pharmaceutical Tablets

      Feature Of The Week 9/8/13: Austrian Researchers Investigate OCT for Analysis of Coatings in Pharmaceutical Tablets

      Tablet coating is a common pharmaceutical technique to apply a thin continuous layer of solid on the top of a tablet or a granule containing active pharmaceutical ingredients (APIs). The coating itself can serve for different purposes. On the one hand we have the so-called “immediate-release coatings”, which do not have any special effect on the pharmaceutical impact of the tablet, but well on the acceptance among patients and therefore on the commercial success. Examples are increasing the visual attractiveness, taste masking and brand recognition. On the other hand it is possible to apply coatings which actually influence the overall ...

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    11. Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

      Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

      Tablet coating is a common pharmaceutical technique to apply a thin continuous layer of solid on the top of a tablet or a granule containing active pharmaceutical ingredients (APIs). Coating thickness and homogeneity are critical parameters regarding the drug release rate, and consequently a direct or indirect monitoring strategy of these critical process parameters is essential. With the aid of Optical Coherence Tomography (OCT) it is not only possible to measure the absolute coating thickness, but also to detect inhomogeneities in the coating or substrate material. In this work the possible application of OCT as in-line method for monitoring pharmaceutical ...

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    12. Feature Of The Week 3/10/13: Optical Coherence Tomography for Apple Surface Structure Evaluation

      Feature Of The Week 3/10/13: Optical Coherence Tomography for Apple Surface Structure Evaluation

      Worldwide a lot of effort is invested in delivering fruit of the highest quality to the consumer. This means that the fruit should look good, taste good and preserve these properties for a sufficiently long period of time after harvest in order for the fruit to be of commercial value. Of course many aspects need to be considered, but here we will focus on the function of the peel. The first thing that meets the eye of the consumer is the peel of the fruit, and in many cases this is the only quality criterion that the consumer uses to ...

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    13. First Symposium on OCT for Non-Destructive Testing (OCT4NT) held in Linz Austria a Success

      First Symposium on OCT for Non-Destructive Testing (OCT4NT) held in Linz Austria a Success

      On the 13 th and 14 th of February 2013 the RECENDT hosted the First International Symposium on Optical Coherence Tomography for Non-Destructive Testing – OCT4NDT ( www.oct4ndt.com ) in Linz, Austria. The event was attended by around 65 researchers and company delegates from all over the world (covering 18 different countries on five different continents). During 27 talks and a poster session the different research groups had the possibility to present their work in front of an interested audience. The OCT4NDT provided a platform for the discussion of new ideas and applications and for establishing new future collaborations. Therefore the ...

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    14. Optical coherence tomography visualizes microstructure of apple peel

      Optical coherence tomography visualizes microstructure of apple peel

      Optical coherence tomography (OCT) has emerged recently as a non-destructive technique to visualize subsurface structures of materials. The objective of this work was to investigate whether OCT is an appropriate method to non-destructively assess the peel structural properties of apple fruit and to compare OCT to confocal microscopy and micro-CT. Peel structural properties of apples from different cultivars (‘Braeburn’, ‘Arlet’, ‘Royal Gala’ and ‘Ida Red’) were measured. The effects of preharvest fertilization treatments and storage duration on calculated structural properties of apple peel from OCT images were investigated. It was found that OCT is a fast, high resolution and high ...

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    15. Announcing The First International Symposium on Optical Coherence Tomography for Non-Destructive Testing (OCT4NDT) February 13-14, 2013 Linz Austria

      Announcing The First International Symposium on Optical Coherence Tomography for Non-Destructive Testing (OCT4NDT) February 13-14, 2013 Linz Austria

      Optical coherence tomography (OCT) applications in the field of non-destructive testing (NDT) have grown immensely over the past few years. In order to pave the ground for a new OCT for NDT community we are pleased to announce the First International Symposium on OCT4NDT! The symposium is intended as a get-together for people working in this field and aims at initiating new ideas and projects. . For more information please click Here .

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    16. Ambiguity-free spectral-domain optical coherence tomography for determining the layer thicknesses in fluttering foils in real time

      Ambiguity-free spectral-domain optical coherence tomography for determining the layer thicknesses in fluttering foils in real time

      When imaging thick or axially moving samples with spectral-domain optical coherence tomography, mirror terms overlapping with the signals of interest can cause ambiguities. These ambiguities complicate the analysis of the imaged structures and are especially troublesome for processes in which sample parameters have to be monitored in a fully automated way and in real time. In this study we focus on a purely hardware-based approach to overcome this problem. The method is based on shifting and shaping the sensitivity profile by spatially separating the two interferometer beams on the diffraction grating in the spectrometer. The usefulness of the approach, including ...

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    17. Evaluation of structural change and local strain distribution in polymers comparatively imaged by FFSA and OCT techniques

      Evaluation of structural change and local strain distribution in polymers comparatively imaged by FFSA and OCT techniques

      Mechanical material testing combined with optical coherence tomography (OCT) allows for the first time the immediate detection of inner structural changes along with a qualitative observation of the local strain distribution in surface near bulk regions of semitransparent and translucent specimens. In addition to a 3D full field strain analysis (FFSA) system based on digital image correlation (DIC), a customized spectral domain OCT system operating at 1550 nm was applied for investigation. Exemplified by tensile testing of elastomer particle filled polypropylene specimens, local dissimilarity evaluation of the OCT images was performed. The results show the high potential of OCT to ...

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    18. Non-destructive analysis of tablet coatings with optical coherence tomography

      Non-destructive analysis of tablet coatings with optical coherence tomography

      Optical coherence tomography (OCT) is a non-invasive analysis technique allowing fast and high-quality cross-sectional imaging of scattering media. OCT is based on the physical phenomenon of low coherence interferometry and is thus well suited to image layered structures. In this paper, high-speed spectral domain OCT was used for the characterization of pharmaceutical tablet coatings, sampled at different stages of an industrial drum spray coating process, comprising tablets with a coating thickness ranging from uncoated to a target coating thickness of about 70 μm. In addition to the OCT investigation of layer thickness and homogeneity, tablet weight gain and tablet diameters ...

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    19. Dr. Michael Leitner, Head of OCT Group at RECENDT, Webcast June 29th

      Dr. Michael Leitner, Head of OCT Group at RECENDT, Webcast June 29th

      Optical coherence tomography (OCT) is a non-invasive imaging technique allowing fast and high-quality two- and three dimensional imaging of semi-transparent and turbid media. So far, biomedical research and diagnostics have been the main driving forces for the reported applications and progress in OCT. However, the characteristics of OCT, specifically the ability to provide high-resolution images and depth-resolved information also in strongly scattering media in a contact-free and non destructive way, render this technique also attractive for a broad spectrum of research topics and applications outside the biomedical field.In this webcast, Dr. Michael Leitner, head of the optical coherence tomography ...

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    1-19 of 19
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    1. (19 articles) Michael Leitner
    2. (14 articles) RECENDT
    3. (6 articles) Daniel Markl
    4. (5 articles) Thorlabs
    5. (4 articles) Andreas Buchsbaum
    6. (2 articles) K. U. Leuven
    7. (2 articles) University of Graz
    8. (2 articles) Pieter Verboven
    9. (1 articles) David Stifter
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    Dr. Michael Leitner, Head of OCT Group at RECENDT, Webcast June 29th Non-destructive analysis of tablet coatings with optical coherence tomography Evaluation of structural change and local strain distribution in polymers comparatively imaged by FFSA and OCT techniques Ambiguity-free spectral-domain optical coherence tomography for determining the layer thicknesses in fluttering foils in real time Announcing The First International Symposium on Optical Coherence Tomography for Non-Destructive Testing (OCT4NDT) February 13-14, 2013 Linz Austria Optical coherence tomography visualizes microstructure of apple peel First Symposium on OCT for Non-Destructive Testing (OCT4NT) held in Linz Austria a Success Feature Of The Week 3/10/13: Optical Coherence Tomography for Apple Surface Structure Evaluation Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets Feature Of The Week 9/8/13: Austrian Researchers Investigate OCT for Analysis of Coatings in Pharmaceutical Tablets Alterations of Hyaluronan Metabolism in Acute Coronary Syndrome: Implications for Plaque Erosion The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography