1. Articles from Erling Falk

    1-8 of 8
    1. A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

      A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography

      Purpose Improve mapping and registration of longitudinal view on histopathology vessels in a three-dimensional alignment procedure for postmortem quantitative coronary plaque analyses. This new procedure is applied and results shown using calcified coronary plaque analyses within post-mortem computed tomography angiography (PMCTA), optical coherence tomography (OCT) and the gold standard of histopathology. Results In total, 338 annotated histopathology images were included, 166 PMCTA transversal images and 285 OCT images were aligned in the comparison. The results from the comparison using the alignment procedure showed overall that the calcified plaques seem to be overestimated by PMCTA and underestimated by OCT. Conclusions The ...

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    2. Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis

      Aims: In-vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We investigated this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolemic mini-pigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially sectioned and co-registered with OCT using a validated algorithm. Lesions were adjudicated using the Virmani classification and PB assessed from histology. OCT had a high sensitivity, but modest specificity (92 ...

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    3. Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Background— Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma. Methods and Results— D374Y -PCSK9 hypercholesterolemic minipigs (n=5) were instrumented with an intracoronary shear-modifying stent (SMS). Frequency-domain optical coherence tomography was obtained at baseline, immediately poststent, 19 weeks, and 34 weeks, and used to compute shear stress metrics of disturbed flow. At 34 weeks, plaque type was assessed within serially collected histological sections and coregistered to ...

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    4. Update on acute coronary syndromes: the pathologists' view

      Update on acute coronary syndromes: the pathologists' view

      Although mortality rates from coronary heart disease in the western countries have declined in the last few decades, morbidity caused by this disease is increasing and a substantial number of patients still suffer acute coronary syndrome (ACS) and sudden cardiac death. Acute coronary syndrome occurs as a result of myocardial ischaemia and its manifestations include acute myocardial infarction and unstable angina. Culprit plaque morphology in these patients varies from thrombosis with or without coronary occlusion to sudden narrowing of the lumen from intraplaque haemorrhage. The coronary artery plaque morphologies primarily responsible for thrombosis are plaque rupture, and plaque erosion, with ...

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    5. Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging

      Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging

      Background In studies where cross-sectional images of coronary arteries obtained with different imaging modalities are compared, the importance of correct co-localization and matching of images along the coronary artery longitudinal axis is obvious. However, it appears neglected that correct spatial orientation of the cross-sectional plane may not be obtainable just by rotating the images to ensure co-localization of identifiable landmarks such as sidebranches. A cross-section has two sides, one facing proximally and the other distally, and pairs of images reconstructed corresponding to these opposite points of view are mirror images of each other and not superimposable. This may be difficult ...

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      Mentions: Abbott
    6. Non-invasive imaging of atherosclerosis

      Non-invasive imaging of atherosclerosis

      Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes, and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. It is well known that the risks of atherosclerotic plaque rupture are not well correlated with stenosis severity. Lumenography has a central place for defining the site and severity of vascular stenosis as a prelude to intervention for relief of symptoms due to blood flow limitation. Atherosclerosis develops within the arterial wall; this is not imaged by lumenography and hence it provides ...

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    7. In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

      In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

      Intravascular optical coherence tomography (OCT) is increasingly being used to assess coronary vessel pathology in vivo due to its unrivalled high resolution of 10–20 µm. Previous reports have shown that OCT is capable of visualizing thin-cap fibroatheromas (TCFAs), 1 which are thought to be the precursor lesions of ruptured plaques responsible for the majority of thrombosis-mediated sudden death. 2 In addition, OCT is able to identify features that have been related to the advancement of atherosclerotic lesions, including neovascularization 3,4 and macrophage infiltration.5,6 It is against this background that Uemura and colleagues describe the baseline OCT ...

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    8. First In Vivo Demonstration of Coronary Edema in Culprit Lesion of Patient With Acute Coronary Syndrome by Cardiovascular Magnetic Resonance

      First In Vivo Demonstration of Coronary Edema in Culprit Lesion of Patient With Acute Coronary Syndrome by Cardiovascular Magnetic Resonance
      Atherosclerosis is a chronic, progressive, inflammatory disease causing multiple lesions in the intima of large and medium-sized arteries. 1 A minority of atherosclerotic lesions referred to as vulnerable plaques (VPs) may suddenly precipitate thrombosis, leading to life-threatening events such as acute myocardial infarction and ischemic stroke. The most common VP is the rupture-prone type, also known as thin-cap fibroatheromas, which are characterized by a large necrotic core with a thin and inflamed fibrous cap, outward remodeling mitigating luminal obstruction, neovascularization, plaque hemorrhage, adventitial inflammation, and a “spotty” pattern of calcifications. 2 Among these features, inflammation and angiogenesis are believed to ...
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    1-8 of 8
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    1. (5 articles) Aarhus University
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    First In Vivo Demonstration of Coronary Edema in Culprit Lesion of Patient With Acute Coronary Syndrome by Cardiovascular Magnetic Resonance In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts? Non-invasive imaging of atherosclerosis Spatial orientation of cross-sectional images of coronary arteries: point of view in intracoronary imaging Update on acute coronary syndromes: the pathologists' view Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs Plaque Burden Influences Accurate Classification of Fibrous Cap Atheroma by In-Vivo Optical Coherence Tomography in a Porcine Model of Advanced Coronary Atherosclerosis A novel alignment procedure to assess calcified coronary plaques in histopathology, post-mortem computed tomography angiography and optical coherence tomography Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing