1. Articles from Julia W. Evans

    1-9 of 9
    1. Error Budget Analysis for an Adaptive Optics Optical Coherence Tomography System

      Error Budget Analysis for an Adaptive Optics Optical Coherence Tomography System
      The combination of adaptive optics (AO) technology with optical coherence tomography (OCT) instrumentation for imaging the retina has proven to be a valuable tool for clinicians and researchers in understanding the healthy and diseased eye. The micrometer-isotropic resolution achieved by such a system allows imaging of the retina at a cellular level, however imaging of some cell types remains elusive. Improvement in contrast rather than resolution is needed and can be achieved through better AO correction of wavefront aberration. A common tool for assessing and ultimately improving AO system performance is the development of an error budget. Specifically, this is ...
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    2. Optical coherence tomography and Raman spectroscopy of the ex-vivo retina

      Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo imaging combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. We present our first results and discuss the challenges ...
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    3. Cellular resolution volumetric in vivo retinal imaging with adaptive optics–optical coherence tomography

      Cellular resolution volumetric in vivo retinal imaging with adaptive optics–optical coherence tomography
      Ultrahigh-resolution adaptive optics–optical coherence tomography (UHR-AO-OCT) instrumentation allowing monochromatic and chromatic aberration correction was used for volumetric in vivo retinal imaging of various retinal structures including the macula and optic nerve head (ONH). Novel ... [Opt. Express 17, 4084-4094 (2009)]
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    4. Performance of a MEMS-based AO-OCT system using Fourier reconstruction

      Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution (3.5 µm isotropic), 3-D images of the retina. The AO-OCT system at UC Davis has demonstrated the utility of this technology for microscopic, volumetric, in vivo retinal imaging. The current system uses an AOptix bimorph deformable mirror (DM) for low-order, high-stroke correction and a 140-actuator Boston Micromachines DM for high-order correction. Developments to improve performance or functionality of the instrument are on-going. Based on previous work in system characterization we have focused on improved AO control. We present preliminary results and ...
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    5. Optical coherence tomography and Raman spectroscopy of the retina

      Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analy ... [Proc. SPIE 7171, 71710O (2009)] published Fri Feb 20, 2009.
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    6. Combined adaptive optics: optical coherence tomography and adaptive optics: scanning laser ophthalmoscopy system for retinal imaging

      We describe a novel instrument that combines adaptive optics - Fourier-domain optical coherence tomography (AO-OCT) with an adaptive optics scanning laser ophthalmoscope (AO-SLO). Both systems share a common AO sub-system and vertical scanner to permit simultaneous acquisition of retinal images from ... [Proc. SPIE 7163, 71630F (2009)] published Wed Feb 18, 2009.
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    7. Ultra-high resolution adaptive optics: optical coherence tomography for in vivo imaging of healthy and diseased retinal structures

      Ultra-high isotropic resolution imaging of retinal structures was made possible with an adaptive optics system using dual deformable mirrors and a Fourier-domain optical coherence tomography (Fd-OCT) system with correction for longitudinal chromatic aberration. This system was used to image microsco ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 684408 (2008)] published Mon Feb 11, 2008.
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    8. Performance of a MEMS-based AO-OCT system

      Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution, 3-D images of the retina. The AO-OCT system at UC Davis has been under development for 2 years and has demonstrated the utility of this technology for microsc ... [Proc. SPIE Int. Soc. Opt. Eng. 6888, 68880G (2008)] published Fri Feb 8, 2008.
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    9. Compact MEMS-based adaptive optics: optical coherence tomography for clinical use

      We describe a compact MEMS-based adaptive optics (AO) optical coherence tomography (OCT) system with improved AO performance and ease of clinical use. A typical AO system consists of a Shack-Hartmann wavefront sensor and a deformable mirror that measures and corrects the ocular and system aberrations. Because of limitations on current deformable mirror technologies, the amount of real-time ocular-aberration compensation is restricted and small in previous AO-OCT instruments. In this instrument, we incorporate an optical apparatus to correct the spectacle aberrations of the patients such as myopia, hyperopia and astigmatism. This eliminates the tedious process of using trial lenses in clinical ...
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    1-9 of 9
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  2. Topics in the News

    1. (9 articles) UC Davis
    2. (9 articles) Lawrence Livermore National Laboratory
    3. (2 articles) Boston Micromachines
    4. (1 articles) Indiana University
    5. (1 articles) San Raffaele Scientfic Institute
    6. (1 articles) Carl Zeiss Meditec
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