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Articles from Julia W. Evans

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  1. Error Budget Analysis for an Adaptive Optics Optical Coherence Tomography System

    Explore Article opticsinfobase.org (Jul 24 2009) Ophthalmology

    Error Budget Analysis for an Adaptive Optics Optical Coherence Tomography System The combination of adaptive optics (AO) technology with optical coherence tomography (OCT) instrumentation for imaging the retina has proven to be a valuable tool for clinicians and researchers in understanding the healthy and diseased eye. The micrometer-isotropic resolution achieved by such a system allows imaging of the retina at a cellular level, however imaging of some cell types remains elusive. Improvement in contrast rather than resolution is needed and can be achieved through better AO correction of wavefront aberration. A common tool for assessing and ultimately improving AO system performance is the development of an error budget. Specifically, this is ... (Read Full Article)

    Comment on Article Mentions:   John S. Werner   Scot S. Olivier   Steven M. Jones

  2. Optical coherence tomography and Raman spectroscopy of the ex-vivo retina

    Explore Article www3.interscience.wiley.com (Jun 30 2009) Ophthalmology

    Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo imaging combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. We present our first results and discuss the challenges ... (Read Full Article)

    Comment on Article Mentions:   John S. Werner   UC Davis   Robert J. Zawadzki

  3. Cellular resolution volumetric in vivo retinal imaging with adaptive optics–optical coherence tomography

    Explore Article opticsinfobase.org (Mar 2 2009) Ophthalmology

    Cellular resolution volumetric in vivo retinal imaging with adaptive optics–optical coherence tomography Ultrahigh-resolution adaptive optics–optical coherence tomography (UHR-AO-OCT) instrumentation allowing monochromatic and chromatic aberration correction was used for volumetric in vivo retinal imaging of various retinal structures including the macula and optic nerve head (ONH). Novel ... [Opt. Express 17, 4084-4094 (2009)] (Read Full Article)

    Comment on Article Mentions:   John S. Werner   Robert J. Zawadzki   Julia W. Evans

  4. Performance of a MEMS-based AO-OCT system using Fourier reconstruction

    Explore Article SPIE Digital Library (Feb 23 2009) Ophthalmology

    Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution (3.5 µm isotropic), 3-D images of the retina. The AO-OCT system at UC Davis has demonstrated the utility of this technology for microscopic, volumetric, in vivo retinal imaging. The current system uses an AOptix bimorph deformable mirror (DM) for low-order, high-stroke correction and a 140-actuator Boston Micromachines DM for high-order correction. Developments to improve performance or functionality of the instrument are on-going. Based on previous work in system characterization we have focused on improved AO control. We present preliminary results and remaining ... (Read Full Article)

    Comment on Article Mentions:   John S. Werner   UC Davis   Julia W. Evans

  5. Optical coherence tomography and Raman spectroscopy of the retina

    Explore Article SPIE Digital Library (Feb 20 2009) Ophthalmology

    Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analy ... [Proc. SPIE 7171, 71710O (2009)] published Fri Feb 20, 2009. (Read Full Article)

    Comment on Article Mentions:   John S. Werner   Robert J. Zawadzki   Julia W. Evans

  6. Combined adaptive optics: optical coherence tomography and adaptive optics: scanning laser ophthalmoscopy system for retinal imaging

    Explore Article SPIE Digital Library (Feb 18 2009) Ophthalmology

    We describe a novel instrument that combines adaptive optics - Fourier-domain optical coherence tomography (AO-OCT) with an adaptive optics scanning laser ophthalmoscope (AO-SLO). Both systems share a common AO sub-system and vertical scanner to permit simultaneous acquisition of retinal images from ... [Proc. SPIE 7163, 71630F (2009)] published Wed Feb 18, 2009. (Read Full Article)

    Comment on Article Mentions:   John S. Werner   Steven M. Jones   Lawrence Livermore National Laboratory

  7. Ultra-high resolution adaptive optics: optical coherence tomography for in vivo imaging of healthy and diseased retinal structures

    Explore Article SPIE Digital Library (Feb 11 2008) Ophthalmology

    Ultra-high isotropic resolution imaging of retinal structures was made possible with an adaptive optics system using dual deformable mirrors and a Fourier-domain optical coherence tomography (Fd-OCT) system with correction for longitudinal chromatic aberration. This system was used to image microsco ... [Proc. SPIE Int. Soc. Opt. Eng. 6844, 684408 (2008)] published Mon Feb 11, 2008. (Read Full Article)

    Comment on Article Mentions:   Steven M. Jones   Robert J. Zawadzki   John S. Werner

  8. Performance of a MEMS-based AO-OCT system

    Explore Article SPIE Digital Library (Feb 8 2008) Ophthalmology

    Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution, 3-D images of the retina. The AO-OCT system at UC Davis has been under development for 2 years and has demonstrated the utility of this technology for microsc ... [Proc. SPIE Int. Soc. Opt. Eng. 6888, 68880G (2008)] published Fri Feb 8, 2008. (Read Full Article)

    Comment on Article Mentions:   Robert J. Zawadzki   Julia W. Evans   John S. Werner

  9. Compact MEMS-based adaptive optics: optical coherence tomography for clinical use

    Explore Article SPIE Digital Library (Feb 8 2008) Ophthalmology

    We describe a compact MEMS-based adaptive optics (AO) optical coherence tomography (OCT) system with improved AO performance and ease of clinical use. A typical AO system consists of a Shack-Hartmann wavefront sensor and a deformable mirror that measures and corrects the ocular and system aberrations. Because of limitations on current deformable mirror technologies, the amount of real-time ocular-aberration compensation is restricted and small in previous AO-OCT instruments. In this instrument, we incorporate an optical apparatus to correct the spectacle aberrations of the patients such as myopia, hyperopia and astigmatism. This eliminates the tedious process of using trial lenses in clinical ... (Read Full Article)

    Comment on Article Mentions:   Steven M. Jones   Lawrence Livermore National Laboratory   John S. Werner

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