1. Articles from Monika Fleckenstein

    1-11 of 11
    1. Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

      Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration

      Importance Sensitive outcome measures for disease progression are needed for treatment trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Objective To quantify photoreceptor degeneration outside regions of GA in eyes with nonexudative AMD, to evaluate its association with future GA progression, and to characterize its spatio-temporal progression. Design, Setting, and Participants Monocenter cohort study (Directional Spread in Geographic Atrophy [ NCT02051998 ]) and analysis of data from a normative data study at a tertiary referral center. One hundred fifty-eight eyes of 89 patients with a mean (SD) age of 77.7 (7.1) years, median area of GA of ...

      Read Full Article
    2. Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Importance The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but currently poorly understood. Background Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT‐A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking. Design Retrospective, observational study. Participants Twenty patients (31 eyes) with PXE. Methods OCT, FA and OCT‐A imaging was performed in each eye and graded separately by independent readers. Main Outcome Measures Diagnostic accuracy, sensitivity and specificity to detect CNVs ...

      Read Full Article
    3. Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy

      Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy

      Purpose : To investigate structural correlates corresponding to the appearance of increased fundus autofluorescence (FAF) in the perilesional area of geographic atrophy (GA) secondary to age-related macular degeneration. Methods : Serial FAF images of 181 eyes with GA of 134 patients participating in the Directional Spread in Geographic Atrophy study (NCT02051998) were screened for increased FAF spots that had developed during the review period. Thickness and reflectivity of the retinal pigment epithelium (RPE)–basal lamina complex, as well as the integrity of the external limiting membrane (ELM) and the ellipsoid zone (EZ), respectively, in corresponding optical coherence tomography (OCT) scans were compared ...

      Read Full Article
    4. In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging

      In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging

      Purpose To determine fundus autofluorescence (FAF) signal variations and corresponding microstructural alterations on spectral-domain optical coherence tomography (SD-OCT) in areas of funduscopically visible drusen associated with age-related macular degeneration (AMD). Methods Thirty eyes from 22 patients with geographic atrophy (GA) secondary to AMD (median age 74, range 64–87 years), who had undergone retinal imaging including color fundus photography (CFP), FAF and SD-OCT (Spectralis HRA+OCT; Heidelberg Engineering GmbH, Heidelberg, Germany) were retrospectively analyzed. In each eye, at least one druse (≥63 μm) in the perilesional zone of GA recorded on CFP was analyzed. Relative FAF intensities and alterations in ...

      Read Full Article
    5. Imaging Geographic Atrophy in Age-Related Macular Degeneration

      Imaging Geographic Atrophy in Age-Related Macular Degeneration
      Advances in retinal imaging technology have largely contributed to the understanding of the natural history, prognostic markers and disease mechanisms of geographic atrophy (GA) due to age-related macular degeneration. There is still no therapy available to halt or slow the disease process. In order to evaluate potential therapeutic effects in interventional trials, there is a need for precise quantification of the GA progression rate. Fundus autofluorescence imaging allows for accurate identification and segmentation of atrophic areas and currently represents the gold standard for evaluating progressive GA enlargement. By means of high-resolution spectral-domain optical coherence tomography, distinct microstructural alterations related to ...
      Read Full Article
    6. Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration

      Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration
      Purpose: To analyze outer retinal changes within the atrophic lesion in patients with geographic atrophy (GA) secondary to age-related macular degeneration. Methods: Twenty-one simultaneously obtained fundus autofluorescence (FAF, excitation:488 nm; emission:500-700 nm) and spectral-domain optical coherence tomography (SD-OCT) scans (Spectralis HRA+OCT, Heidelberg Engineering, Germany) of 21 GA patients (mean age 75.1±7.4 years) were included and separately exported. Two readers independently graded the following parameters: Width of the atrophic lesion on the FAF image at the site where the SD-OCT scan had been placed. On the SD-OCT image, widths of the linear disruption of the ...
      Read Full Article
    7. Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen

      Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen
      Purpose: The purpose of this study was to investigate morphologic differences in a consecutive case series of patients suffering from adult-onset vitelliform macular dystrophy with cuticular drusen (CD) compared with another patient group with a vitelliform lesion only using high-resolution in vivo retinal imaging. Methods: Simultaneous spectral domain optical coherence tomography (870 nm, 40.000 A-scans per second) and confocal scanning laser ophthalmoscopy were performed in 6 patients (12 eyes) with adult-onset vitelliform macular dystrophy using a combined instrument (Spectralis HRA+OCT; Heidelberg Engineering). Results: Mean age was 69 years (59-82 years), and mean visual acuity was 20/80. The ...
      Read Full Article
    8. Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration

      Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration
      Purpose. To investigate, with the use of spectral-domain optical coherence tomography (SD-OCT), microstructural alterations over time in eyes with progressive geographic atrophy (GA) due to age-related macular degeneration. Methods. Forty-six eyes of 26 patients (median age, 77.9 years [interquartile range (IQR), 71.8–81.0]) with GA without evidence of active or previous neovascular disease at baseline were examined by simultaneous confocal scanning laser ophthalmoscopy (cSLO) and SD-OCT. Serial examinations with alignment of follow-up to baseline scans were performed over a median period of 12.2 months (IQR, 10.2–15.3). Longitudinal SD-OCT variations were evaluated, including quantification ...
      Read Full Article
    9. Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging of Reticular Drusen Associated with Age-Related Macular Degeneration

      Purpose: To determine microstructural retinal alterations associated with reticular drusen in patients with age-related macular degeneration (AMD) using high-resolution in vivo imaging techniques.Design: Retrospective case series.Participants: A total of 116 eyes of 78 AMD patients with reticular drusen were examined.Methods: Simultaneous spectral-domain optical coherence tomography (SD OCT; 870 nm, 40 000 A-scans/sec) and near-infrared confocal scanning laser ophthalmoscopy (cSLO; 830 nm) were performed using a combined imaging instrument (Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany). Individual anatomic layers in SD OCT were evaluated and correlated to en face cSLO fundus imaging.Main Outcome Measures: Description of ...
      Read Full Article
    10. Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography

      Purpose: To evaluate the clinical relevance of a new diagnostic modality, simultaneous confocal scanning laser ophthalmoscopy (cSLO) and high-speed, high-resolution, spectral-domain optical coherence tomography (OCT), for the visualization of macular pathologies. Methods: OCT images and simultaneous recording of fluorescein angiography, indocyanine green (ICG) angiography, infrared, and blue reflectance ('red-free') or fundus autofluorecence (FAF) images were obtained with a novel imaging device (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany). An optically pumped solid-state laser generated the excitation wavelength (488 nm) required for blue reflectance, FAF and fluorescein angiography images. For ICG angiography and infrared imaging, diode laser sources at 790 and ...
      Read Full Article
    11. Correlation of Lines of Increased Autofluorescence in Macular Dystrophy and Pigmented Paravenous Retinochoroidal Atrophy by Optical Coherence Tomography

      Discrete lines of increased fundus autofluorescence (FAF) have recently been described in various retinal dystrophies.1-2 It has been shown that these lines demarcate areas with impaired retinal sensitivity from those without and may constrict or expand in different retinal dystrophies over time.1-2 Morphological changes corresponding to lines of increased FAF have not been described yet. Likewise, the mechanism underlying the abnormal accumulation of lipofuscin and increased FAF is unknown. In retinitis pigmentosa, abnormally increased FAF commonly forms a parafoveal ring or annulus. Recent optical coherence tomography (OCT) findings suggest that the band that represents the interface of the ...
      Read Full Article
    1-11 of 11
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (11 articles) University of Bonn
    2. (5 articles) Heidelberg Engineering
    3. (1 articles) Stanford University
    4. (1 articles) Ludwig Maximilian University of Munich
    5. (1 articles) Oxford University
    6. (1 articles) University of Utah
    7. (1 articles) Carl Zeiss Meditec
    8. (1 articles) Sun Yat-Sen University
    9. (1 articles) Vanderbilt University
    10. (1 articles) Yale University
    11. (1 articles) Cleveland Clinic
    12. (1 articles) Northwestern University
    13. (1 articles) University of North Carolina
    14. (1 articles) Carl Zeiss Meditec
    15. (1 articles) Alcon
    16. (1 articles) Audioptics Medical
  3. Popular Articles

  4. Picture Gallery

    Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration Spectral Domain Optical Coherence Tomography in Adult-Onset Vitelliform Macular Dystrophy With Cuticular Drusen Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration Imaging Geographic Atrophy in Age-Related Macular Degeneration In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging Structural Changes in Optical Coherence Tomography Underlying Spots of Increased Autofluorescence in the Perilesional Zone of Geographic Atrophy Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study