1. Articles from Evangelos S. Gragoudas

    1-3 of 3
    1. Evaluation of choroidal lesions with swept-source optical coherence tomography

      Evaluation of choroidal lesions with swept-source optical coherence tomography

      Aims The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation. Methods This was a prospective, cross-sectional study. Patients with choroidal melanocytic lesions <3 mm in thickness on B-scan ultrasonography were recruited. All participants underwent SS-OCT. On SS-OCT we evaluated qualitative (eg, lesion outline, detection of scleral-choroidal interface and quality of the image) and quantitative (measurement of maximum lesion thickness and the largest basal diameter) parameters. Probability of optimal image quality was examined using ordered logistic regression models. The main outcome measure was quality ...

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    2. Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

      Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
      Purpose The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. Methods CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was evaluated by coupling the NP with a green fluorescing protein plasmid (NP-GFPg). Rhodamine labeling (Rd-NP) was used to localize NP in choroidal flatmounts. Rd-NP-GFPg particles were injected intravenously on weeks 1, 2, or 3. In the treatment arm, rats received NP containing a ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) National Institutes of Health
    2. (2 articles) Massachusetts Eye and Ear Infirmary
    3. (2 articles) Harvard University
    4. (2 articles) Harvard University
    5. (1 articles) Stanford University
    6. (1 articles) University of Coimbra
    7. (1 articles) University of Michigan
    8. (1 articles) Massachusetts Institute of Technology
    9. (1 articles) Netan Choudhry
    10. (1 articles) Andrea Giani
    11. (1 articles) Rajesh C. Rao
    12. (1 articles) Topcon Medical Systems
    13. (1 articles) Texas A&M University
    14. (1 articles) FDA
    15. (1 articles) University of Southern California
    16. (1 articles) Dresden University of Technology
    17. (1 articles) Francesco Prati
    18. (1 articles) Edmund Koch
    19. (1 articles) Lars Kirsten
    20. (1 articles) Javier A. Jo
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