1. Articles from Tan Liu

    1-8 of 8
    1. Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    2. Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    3. Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

      Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

      We accomplished spectral domain optical coherence tomography and auto-fluorescence microscopy for imaging the retina with a single broadband light source centered at 480 nm. This technique is able to provide simultaneous structural imaging and lipofuscin molecular contrast of the retina. Since the two imaging modalities are provided by the same group of photons, their images are intrinsically registered. To test the capabilities of the technique we periodically imaged the retinas of the same rats for four weeks. The images successfully demonstrated lipofuscin accumulation in the retinal pigment epithelium with aging. The experimental results showed that the dual-modal imaging system can ...

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    4. A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography

      A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography

      Quantitatively determining physiological parameters at a microscopic level in the retina furthers the understanding of the molecular pathways of blinding diseases, such as diabetic retinopathy and glaucoma. An essential parameter, which has yet to be quantified noninvasively, is the retinal oxygen metabolic rate (rMRO 2 ). Quantifying rMRO 2 is challenging because two parameters, the blood flow rate and hemoglobin oxygen saturation (sO 2 ), must be measured together. We combined photoacoustic ophthalmoscopy (PAOM) with spectral domain-optical coherence tomography (SD-OCT) to tackle this challenge, in which PAOM measured the sO 2 and SD-OCT mapped the blood flow rate. We tested the integrated ...

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    5. Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography

      Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography

      We achieved fast and automatic retinal vessel segmentation by employing the active contours method in Doppler spectral-domain optical coherence tomography (SD-OCT). In a typical OCT B-scan image, we first extracted the phase variations between adjacent A-lines and removed bulk motion. Then we set the initial contour as the boundary of the whole image and iterated until all of the segmented vessel contours became stabilized. Using a typical office computer, the whole segmentation took no more than 50 s, making real-time retinal vessel segmentation possible. We tested the active contours method segmentation in both controlled phantom and in vivo rodent eye ...

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    6. Watching while listening to the interaction of photons with bio-tissues

      Watching while listening to the interaction of photons with bio-tissues

      Using a single light source to carry out optical coherence tomography and photoacoustic microscopy simultaneously enables novel studies of optical scattering and absorption in biological tissues. Optical coherence tomography (OCT) and photoacoustic microscopy (PAM) are two microscopic, three-dimensional, noninvasive imaging modalities that are based on different contrast mechanisms. OCT mainly images the optical scattering properties of a sample whereas PAM images optical absorption. Due to these different contrast mechanisms, OCT and PAM provide complementary information about biological tissues. OCT images the microanatomy of a sample (e.g., the histology-like cross-sectional image). It can also image the blood flow velocity by ...

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    7. Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform

      Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform

      Photoacoustic ophthalmoscopy (PAOM) is a newly developed retinal imaging technology that holds promise for both fundamental investigation and clinical diagnosis of several blinding diseases. Hence, integrating PAOM with other existing ophthalmic imaging modalities is important to identify and verify the strengths of PAOM compared with the established technologies and to provide the foundation for more comprehensive multimodal imaging. To this end, we developed a retinal imaging platform integrating PAOM with scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA). In the system, all the imaging modalities shared the same optical scanning and delivery mechanisms, which enabled ...

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    8. Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen

      Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen
      We proposed to measure the metabolic rate of oxygen (MRO2) in small animals in vivo using a multimodal imaging system that combines laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) and spectral-domain optical coherence tomography (SD-OCT). We first tested the capability of the multimodal system to measure flow rate in a phantom made of two capillary tubes of different diameters. We then demonstrated the capability of measuring MRO2 by imaging two parallel vessels selected from the ear of a Swiss Webster mouse. The hemoglobin oxygen saturation (sO2) and the vessel diameter were measured by the LSOR-PAM and the blood flow velocity was measured ...
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    1-8 of 8
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  2. Topics in the News

    1. (7 articles) Northwestern University
    2. (7 articles) Shuliang Jiao
    3. (6 articles) Hao F. Zhang
    4. (3 articles) University of Southern California
    5. (2 articles) University of Wisconsin
    6. (2 articles) University of Miami
    7. (2 articles) Florida International University
    8. (2 articles) Carmen A. Puliafito
    9. (2 articles) Ji Yi
    10. (1 articles) UCLA
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    Combined photoacoustic microscopy and optical coherence tomography can measure metabolic rate of oxygen Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform Watching while listening to the interaction of photons with bio-tissues Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography Motorized capsule for shadow-free OCT imaging and synchronous beam control Notal Vision Diagnostic Clinic reports completion of 6 million ForeseeHome AMD home-monitoring tests Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography