1. Articles from DAVID SARRAF

    49-74 of 74 « 1 2 3
    1. A Comparison Between Optical Coherence Tomography Angiography and Fluorescein Angiography for the Imaging of Type 1 Neovascularization

      A Comparison Between Optical Coherence Tomography Angiography and Fluorescein Angiography for the Imaging of Type 1 Neovascularization

      Purpose : To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA. Methods : Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions. Unmasked graders utilized FA and structural OCT data to determine the diagnosis of type 1 NV. Masked graders evaluated FA ...

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    2. Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Subretinal hyperreflective material imaged with optical coherence tomography angiography

      Purpose The range of subretinal hyperreflective material (SHRM) seen in macular disease includes type 2 macular neovascularization, fibrosis, exudation, vitelliform material and hemorrhage. The prognostic significance of SHRM has been evaluated retrospectively in clinical trials but discriminating SHRM subtypes traditionally requires multiple imaging modalities. The purpose of this study is to describe optical coherence tomography angiography (OCTA) flow characteristics and artifacts which might help to distinguish SHRM subtypes. Design Validity analysis. Methods Patients with age-related macular degeneration (AMD), myopia, pachychoroid disease and macular dystrophy, manifesting SHRM on optical coherence tomography (OCT), were recruited. Clinical chart review and multimodal imaging established ...

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    3. Optical coherence tomography angiography of a retinal astrocytic hamartoma

      Optical coherence tomography angiography of a retinal astrocytic hamartoma

      Retinal astrocytic hamartomas are rare, benign glial tumours that most commonly accompany tuberous sclerosis complex but may occur with neurofibromatosis type 1 or as isolated cases. We present a case of an isolated retinal astrocytic hamartoma, evaluated with multimodal imaging including spectral domain optical coherence tomography (SD-OCT), en face OCT, and OCT angiography. OCT angiography is a novel, noninvasive method for analyzing the retinal capillary system. This modality revealed a central feeder vessel with an associated abnormal vascular plexus, which correlated with the topographic location of the tumour on en face OCT.

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      Mentions: UCLA
    4. Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography

      Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography

      Purpose To assess microvascular blood flow of the deep retinal capillary plexus in eyes with paracentral acute middle maculopathy using optical coherence tomography (OCT) angiography. Design Retrospective, multicenter, observational case series. Methods Clinical and multimodal imaging findings from 8 patients with paracentral acute middle maculopathy were reviewed and analyzed. OCT angiography scans were analyzed and processed, and vessel density was calculated. Results Eight patients (7 male, 1 female, aged 9-82 years) were included. OCT angiography was obtained at either the acute (4 cases) or old stage (4 cases). Scans of the deep capillary plexus showed preservation of perfusion in acute ...

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    5. Optical Coherence Tomography Angiography Of Type 3 Neovascularization Secondary To AGE-RELATED Macular Degeneration

      Optical Coherence Tomography Angiography Of Type 3 Neovascularization Secondary To AGE-RELATED Macular Degeneration

      Purpose: To characterize the vascular structure of Type 3 neovascularization secondary to age-related macular degeneration using optical coherence tomography angiography. Methods: Optical coherence tomography angiography cube scans (3 mm × 3 mm) were acquired in 29 eyes of 24 patients with Type 3 lesions secondary to age-related macular degeneration using the RTVue XR Avanti with AngioVue, Split-spectrum amplitude-decorrelation, and motion correction technology. Automated layer segmentation boundaries were adjusted to best visualize the neovascular complex on en face projection images. Results: A distinct neovascular complex could be identified in 10 (34%) eyes, all of which were active on optical coherence tomography imaging ...

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    6. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL ARTERY OCCLUSION

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL ARTERY OCCLUSION

      Purpose: To describe the retinal microvasculature of the eyes with nonarteritic retinal artery occlusion (RAO) based on optical coherence tomography angiography. Methods: Cross-sectional, prospective, observational study performed from September 2014 through February 2015. En face projection of optical coherence tomography angiography images centered at the macula and optic disk of the eyes presenting with RAO were acquired using the RTVue XR Avanti with AngioVue software. Qualitative analysis of the morphology of the superficial and deep retinal capillary plexuses, and radial peripapillary capillaries was performed. Retinal vasculature images using optical coherence tomography angiography were correlated with fluorescein angiography images. Results: Seven ...

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    7. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF SICKLE CELL MACULOPATHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF SICKLE CELL MACULOPATHY

      Purpose: To report a case of sickle cell retinopathy imaged with optical coherence tomography angiography. Methods: Case report. Results: An asymptomatic 33-year-old man with known sickle cell anemia (SS) presented for routine eye examination. Ultrawide-field fluorescein angiography confirmed areas of temporal nonperfusion without neovascularization and subtle enlargement of the foveal avascular zone in the left eye. Spectral domain optical coherence tomography showed thinning of the inner layers of the temporal macula in both eyes. Optovue split-spectrum amplitude decorrelation angiography optical coherence tomography was performed and showed reduced flow within the superficial and deep macular plexuses of each eye, most severely ...

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      Mentions: Optovue
    8. Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease - American Journal of Ophthalmology

      Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease - American Journal of Ophthalmology

      Purpose To determine the proportion of shallow irregular pigment epithelial detachments in eyes with pachychoroid features that harbor neovascular tissue and to study the morphology of this tissue with optical coherence tomography (OCT) angiography. Design Prospective consecutive cohort study. Methods Patients with pachychoroid spectrum diagnoses and shallow irregular pigment epithelial detachment in at least one eye (study eye) were included. Charts and multimodal imaging were reviewed to determine a dye-angiography detection rate for type 1 neovascularization in study eyes. All patients then underwent OCT angiography prospectively followed by masked segmentation and grading. Results 22 eyes of 16 patients were included ...

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      Mentions: K. Bailey Freund
    9. SUBRETINAL NEOVASCULARIZATION IN MACULAR TELANGIECTASIA TYPE 2: OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY AND TREATMENT RESPONSE

      SUBRETINAL NEOVASCULARIZATION IN MACULAR TELANGIECTASIA TYPE 2: OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY AND TREATMENT RESPONSE

      Purpose: To report the optical coherence tomographic angiography findings and response to treatment in a case of macular telangiectasia Type 2 with subretinal neovascularization. Methods: Case report. Results: A 64-year-old man with macular telangiectasia Type 2 developed subretinal neovascularization, which was imaged on optical coherence tomographic angiography. He was treated with intravitreal aflibercept, and there was a remarkable reduction of flow in the subretinal neovascular network on optical coherence tomographic angiography. Conclusion: Optical coherence tomographic angiography provides detailed information on the retinal microvasculature and subretinal neovascularization in macular telangiectasia Type 2. It can be used to assess response to treatment.

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    10. EN FACE OPTICAL COHERENCE TOMOGRAPHY OF MACULAR MICROCYSTS DUE TO OPTIC NEUROPATHY FROM NEUROMYELITIS OPTICA

      EN FACE OPTICAL COHERENCE TOMOGRAPHY OF MACULAR MICROCYSTS DUE TO OPTIC NEUROPATHY FROM NEUROMYELITIS OPTICA

      Purpose: To describe the multimodal imaging, including en face optical coherence tomography (OCT) and OCT angiography, findings of a case of macular microcysts associated with neuromyelitis optica. Methods: Findings on clinical examination, color fundus photography, fluorescein angiography, fundus autofluorescence, visual fields, and OCT including en face OCT and OCT angiography are presented. Results: A 12-year-old African American boy presented with bilateral optic atrophy from neuromyelitis optica. Clinical examination was notable for bilateral optic nerve head pallor. Visual fields of both eyes showed generalized depression. Fluorescein angiography and fundus autofluorescence were unremarkable. Spectral domain OCT B-scan images showed characteristic paracentral, hyporeflective ...

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    11. Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degenerati

      Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degenerati

      Purpose To analyze type 1 neovascular membranes in age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography, to correlate morphological characteristics with imaging and clinical criteria, and to analyze structural features of type 1 neovascularization sequentially after anti-vascular endothelial growth factor (VEGF) therapy. Design Prospective interventional case series. Methods Macular OCT angiography images were acquired using the RTVue XR Avanti with AngioVue. Distinct morphological patterns and quantifiable features of the neovascular membranes were studied on en face projection images at baseline and follow-up. Results Thirty-three eyes of 25 patients were included. In 75% of the eyes, a highly organized ...

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    12. Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration

      Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration

      Purpose To analyze type 1 neovascular membranes in age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography, to correlate morphological characteristics with imaging and clinical criteria, and to analyze structural features of type 1 neovascularization sequentially after anti-vascular endothelial growth factor (VEGF) therapy. Design Prospective interventional case series. Methods Macular OCT angiography images were acquired using the RTVue XR Avanti with AngioVue. Distinct morphological patterns and quantifiable features of the neovascular membranes were studied on en face projection images at baseline and follow-up. Results Thirty-three eyes of 25 patients were included. In 75% of the eyes, a highly organized ...

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    13. JAMA Ophthalmology | A Promising Future for Optical Coherence Tomography Angiography

      JAMA Ophthalmology | A Promising Future for Optical Coherence Tomography Angiography

      This Viewpoint reports on optical coherence tomography angiography and how its use could greatly enrich our understanding of the ischemic processes affecting different layers of the retinal vasculature. Fluorescein angiography has been the gold standard imaging modality for the retinal vasculature since its groundbreaking introduction in 1961 by Alvis and Novotny and has revolutionized our ability to diagnose diseases of the retinal vasculature and to identify retinal and choroidal neovascularization. 1 Its greatest advantage may lie in its ability to detect dynamic patterns of dye transit and leakage. Various innovations have broadened the use of angiography, including the application of ...

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    14. A Promising Future for Optical Coherence Tomography Angiography

      A Promising Future for Optical Coherence Tomography Angiography

      This Viewpoint reports on optical coherence tomography angiography and how its use could greatly enrich our understanding of the ischemic processes affecting different layers of the retinal vasculature. Fluorescein angiography has been the gold standard imaging modality for the retinal vasculature since its groundbreaking introduction in 1961 by Alvis and Novotny and has revolutionized our ability to diagnose diseases of the retinal vasculature and to identify retinal and choroidal neovascularization. 1 Its greatest advantage may lie in its ability to detect dynamic patterns of dye transit and leakage. Various innovations have broadened the use of angiography, including the application of ...

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    15. TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

      TYPE 3 NEOVASCULARIZATION: Evolution, Association With Pigment Epithelial Detachment, and Treatment Response as Revealed by Spectral Domain Optical Coherence Tomography

      Purpose: To demonstrate the evolution and treatment response of Type 3 neovascularization using spectral domain optical coherence tomography. Methods: We retrospectively analyzed 40 eyes treated with intravitreal anti-vascular endothelial growth factor therapy for Type 3 neovascularization over a variable follow-up period. Results: In 17 eyes, spectral domain optical coherence tomography captured the development of Type 3 neovascularization from punctate hyperreflective foci that preceded any outer retinal defect. The more mature Type 3 lesions were associated with outer retinal disruption and adjacent cystoid macular edema. In addition, 37 of 40 Type 3 lesions (93%) were associated with an underlying pigment epithelial ...

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    16. THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      THE PEARL NECKLACE SIGN: A Novel Spectral Domain Optical Coherence Tomography Finding in Exudative Macular Disease

      Purpose: To report a novel spectral domain optical coherence tomography finding in exudative macular disease, called the pearl necklace sign. Methods: A retrospective case series of 21 eyes (20 patients) with chronic exudative maculopathy resulting from age-related macular degeneration, diabetic macular edema, branch retinal vein occlusion, retinal arterial macroaneurysm, and Coats disease. Spectral domain optical coherence tomography images were carefully evaluated and correlated with color fundus photography, near-infrared reflectance, and fluorescein angiography. Results: A unique spectral domain optical coherence tomography macular finding of hyperreflective dots in a contiguous ring around the inner wall of cystoid spaces in the outer plexiform ...

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      Mentions: K. Bailey Freund
    17. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Purpose of Review To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to ischemia of the retinal deep capillary plexus (DCP). Recent Findings With the advent of high-definition SD-OCT imaging, we are now able to detect deep capillary ischemia. Although cotton wool spots are caused by ischemia of the superficial capillary plexus, PAMM is caused by ischemia of the DCP, and appears as hyper-reflective, band-like lesions in the middle retina, extending from the ...

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    18. Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia

      Purpose of Review: To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to ischemia of the retinal deep capillary plexus (DCP). Recent Findings: With the advent of high-definition SD-OCT imaging, we are now able to detect deep capillary ischemia. Although cotton wool spots are caused by ischemia of the superficial capillary plexus, PAMM is caused by ischemia of the DCP, and appears as hyper-reflective, band-like lesions in the middle retina, extending from the ...

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    19. Grading of posterior staphyloma with spectral-domain optical coherence tomography and correlation with macular disease

      Grading of posterior staphyloma with spectral-domain optical coherence tomography and correlation with macular disease

      OBJECTIVE: To develop a novel grading system for posterior staphyloma imaged by spectral-domain optical coherence tomography (SD-OCT) and to correlate the incidence of macular disease (vitreomacular traction, epiretinal membrane, macular schisis, lamellar macular hole, and full-thickness macular hole) with each grade. DESIGN: Retrospective chart review. PARTICIPANTS: A total of 150 eyes from 89 patients with posterior staphylomas were examined at Jules Stein Eye Institute, University of California Los Angeles. METHODS: Retrospective analysis of the Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, Calif.) database at a large institution (Jules Stein Eye Institute) was performed and eyes with a posterior staphyloma involving the ...

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    20. Optical Coherence Tomography Findings in Ocular Argyrosis

      Optical Coherence Tomography Findings in Ocular Argyrosis

      A 68-year-old Caucasian man with a remote history of daily colloidal silver ingestion presented for ophthalmic examination in which he was noted to have a distinct slate gray skin discoloration. Funduscopy revealed confluent perimacular drusenoid deposits bilaterally, most of which localized at the level of or anterior to the inner segment ellipsoid band by optical coherence tomography (OCT) imaging. Enhanced depth imaging OCT demonstrated marked choroidal thinning. Fluorescein angiogram displayed a dark or silent choroid. Confirmatory serum silver levels were found to be markedly elevated. This report describes a unique geographic maculopathy with large drusenoid deposits anterior to the ellipsoid ...

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    21. MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation

      Purpose: To describe the spectrum of pigment epithelial detachments (PEDs) occurring mainly in age-related macular degeneration and central serous chorioretinopathy and also in other inflammatory, neoplastic and iatrogenic, retinal, and systemic disorders. Methods: Pigment epithelial detachments are divided into drusenoid, serous, vascularized, or mixed categories. Results: The clinical presentation, classification, and natural history of PEDs are reviewed as illustrated with multimodal imaging combining traditional and novel imaging techniques, including fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and spectral domain optical coherence tomography. Most PEDs occur because of pathophysiologic mechanisms taking place below the retinal pigment epithelium that are difficult to ...

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      Mentions: K. Bailey Freund
    22. Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

      Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

      Purpose To demonstrate the mechanism by which retinal pigment epithelium (RPE) tears occur in eyes with neovascular age-related macular degeneration (AMD) treated with intravitreal anti–vascular endothelial growth factor (VEGF) agents using spectral-domain optical coherence tomography (OCT). Design Retrospective observational case series. Methods OCT images of 8 eyes that developed RPE tears following the administration of intravitreal anti-VEGF agents for neovascular AMD were evaluated. Pretear and posttear images were compared in order to elucidate the mechanism by which RPE tears occur in this setting. Results In all eyes, pretear images revealed a vascularized pigment epithelial detachment (PED) containing hyperreflective material ...

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    23. Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath

      Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath

      Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation of syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination and imaging studies of 30 eyes of 19 confirmed cases were analyzed both at the time of presentation and at each follow-up visit. Patients with SD OCT and fluorescein angiography at the time of presentation, and at least three documented follow-up visits after initiation of therapy, were included in the study. Standard treatment of neurosyphilis was given to each patient, including 4 million units of penicillin G ...

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    24. Optical Coherence Tomographic Imaging of Sub-Retinal Pigment Epithelium Lipid

      Optical Coherence Tomographic Imaging of Sub-Retinal Pigment Epithelium Lipid

      Objective To describe an optical coherence tomographic finding of layered hyperreflective bands beneath the retinal pigment epithelium (RPE), the so-called onion sign believed to represent lipid within a vascularized pigment epithelial detachment. Methods This retrospective observational case series involved reviewing clinical histories of patients with the onion sign. Imaging studies analyzed included spectral-domain optical coherence tomography, color and red-free photographs, near infrared reflectance, fundus autofluorescence, and blue-light fundus autofluorescence. Results A total of 22 eyes of 20 patients with sub-RPE hyperreflective bands were identified. There were 15 women and 5 men with a mean patient age of 76 years (range ...

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    25. SOLAR RETINOPATHY: Comparison of Optical Coherence Tomography (OCT) and Fluorescein Angiography (FA)

      Purpose: To compare optical coherence tomography with fluorescein angiography in 11 patients (21 eyes) with central foveal damage from solar retinopathy. Methods: Retrospective, observational case series of 11 patients with solar retinopathy. Dilated funduscopic examination was performed as well as photographic, fluorescein angiography, optical coherence tomography, and Humphrey visual field assessment. Results: Significant foveal pathology was identified in each of the 21 eyes (11 patients). Visual acuity in affected eyes ranged from 20/25 to 20/200. Optical coherence tomography demonstrated foveal atrophy associated with a characteristic defect at the level of the inner and outer segment junction of the ...

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    26. Predictors Of Anti-VEGF-ASSOCIATED Retinal Pigment Epithelial Tear Using Fa And Oct Analysis.

      This is an original study that identifies predictors of anti-VEGF-associated retinal pigment epithelial tear using OCT and FA analysis in eyes with age-related macular degeneration with associated fibrovascular pigment epithelial detachment.Page: 1265DOI: 10.1097/IAE.0b013e31817d5d03Authors: CHIANG, ALLEN MD; CHANG, LOUIS K. MD, PhD; YU, FEI PhD; SARRAF, DAVID MD
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    49-74 of 74 « 1 2 3
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    1. (43 articles) UCLA
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    Optical Coherence Tomographic Imaging of Sub-Retinal Pigment Epithelium Lipid Spectral Domain Optical Coherence Tomography Findings in Patients With Acute Syphilitic Posterior Placoid Chorioretinopath Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography MULTIMODAL IMAGING OF PIGMENT EPITHELIAL DETACHMENT: A Guide to Evaluation Grading of posterior staphyloma with spectral-domain optical coherence tomography and correlation with macular disease A Promising Future for Optical Coherence Tomography Angiography Subretinal hyperreflective material imaged with optical coherence tomography angiography The Retinal Atlas 2nd Edition (Textbook) Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study