1. Articles from Sanjiv S. Gambhir

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    1. Optical coherence contrast imaging using gold nanorods in living mice eyes

      Optical coherence contrast imaging using gold nanorods in living mice eyes

      Background Optical Coherence Tomography (OCT) is a powerful imaging modality to visualize tissue structures, with axial image pixel resolution as high as 1.6 um in tissue. However, OCT is intrinsically limited to providing structural information as the OCT contrast is produced by optically scattering tissues. Methods Here we demonstrate gold nanorods (GNRs) injected into the anterior chamber (AC) and cornea of mice eyes can create a significant OCT signal and hence can be used as a contrast agent for in vivo OCT imaging. Results We show that a low dose of 30 nM of GNRs (13 nm in diameter ...

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    2. Early Diagnosis of Ovarian Carcinoma: Is a Solution in Sight?

      Early Diagnosis of Ovarian Carcinoma: Is a Solution in Sight?
      Ovarian cancer is the most lethal of the gynecologic malignancies. Because ovarian cancer symptoms are subtle and nonspecific, the diagnosis is often delayed until the disease is well advanced. Overall 5-year survival is a rather dismal 50% but can be improved to greater than 90% if the disease is confined to the ovary at the time of diagnosis (generally in fewer than 25% of patients). Effective screening tools are currently not available. Owing to the rather low incidence of the disease in the general population, potential screening tests must provide very high specificity to avoid unnecessary interventions in false-positive cases ...
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    1-2 of 2
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    1. (2 articles) Stanford University
    2. (1 articles) National Institutes of Health
    3. (1 articles) University of Miami
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    Early Diagnosis of Ovarian Carcinoma: Is a Solution in Sight? Optical coherence contrast imaging using gold nanorods in living mice eyes The truth about invisible posterior vitreous structures Increased Macrophage-like Cell Density in Retinal Vein Occlusion as Characterized by en Face Optical Coherence Tomography The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study The Role of Widefield and Ultra Widefield Optical Coherence Tomography in the Diagnosis and Management of Vitreoretinal Diseases Acute Idiopathic Blind Spot Enlargement Syndrome-New Perspectives in the OCT Era Longitudinal Comparison of Constant Artifacts in Optical Coherence Tomography Angiography in Patients with Posterior Uveitis Compared to Healthy Subjects Choriocapillaris Flow Deficits Quantification in Hydroxychloroquine Retinopathy Using Swept-Source Optical Coherence Tomography Angiography Swept-Source OCT Angiography Features in Patients after Macular Hole Surgery Early OCTA Changes of Type 3 Macular Neovascularization Following Brolucizumab Intravitreal Injections