1. Articles from Ya-Ju Lee

    1-12 of 12
    1. Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode

      Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode

      Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of non-ablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the ...

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    2. Early detection of enamel demineralization by optical coherence tomography

      Early detection of enamel demineralization by optical coherence tomography

      Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of ...

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    3. Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography

      Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography

      In this study, we demonstrated the feasibility of using a handheld optical coherence tomography (OCT) for in vivo visualizations of the microstructural and microvascular features of various oral mucosal types. To scan arbitrary locations of the oral mucosa, a scanning probe was developed, composed of a probe body fabricated by a 3D printer, miniaturized two-axis galvanometer, relay lenses, and reflective prism. With a 3D printing technique, the probe weight and the system volume were greatly reduced, enabling the effective improvement of imaging artifacts from unconscious motion and system complexity. Additionally, in our design, the distal end of the probe can ...

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    4. Determination of Coefficient of Thermal Expansion in High Power GaN-Based Light-Emitting Diodes via Optical Coherent Tomography

      Determination of Coefficient of Thermal Expansion in High Power GaN-Based Light-Emitting Diodes via Optical Coherent Tomography

      One of the most challenging issues when operating a high-power light-emitting diode (LED) is to conduct appropriate packaging materials for the reliable thermal management of the entire device. Generally, the considerable amount of heat produced around the junction area of the LED would transfers to the entire device, and causes thermal expansion in the packaging material. It induces strain inevitably, and hinders the output performances and possible applications of high-power LEDs. The coefficient of thermal expansion (CTE) is a physical quantity that indicates the expansion to which value a material will be upon heating. Therefore, as far as an advancement ...

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    5. Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe

      Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe

      Biomedical materials have different optical properties (e.g. absorption) for different wavelengths. Therefore, probing biomedical materials with multiple wavelengths not only can get in-depth understanding of the detected biomedical materials but also can differentiate the detected biomedical materials. To achieve this purpose, in this conference paper, we present our initial results of building up a portable multiple-wavelength biomedical sensing system. At this initial phase, we assembled this kind of system with multiple wavelengths of light sources and photodetectors and preliminarily tested the absorbance of the glucose solutions with different concentrations. The result shows good linearity of the absorbance of the ...

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    6. Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was ...

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    7. Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

      Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode

      Blood coagulation is the clotting and subsequent dissolution of the clot following repair to the damaged tissue. However, inducing blood coagulation is difficult for some patients with homeostasis dysfunction or during surgery. In this study, we proposed a method to develop an integrated system that combines optical coherence tomography (OCT) and laser microsurgery for blood coagulation. Also, an algorithm for positioning of the treatment location from OCT images was developed. With OCT scanning, 2D/3D OCT images and angiography of tissue can be obtained simultaneously, enabling to noninvasively reconstruct the morphological and microvascular structures for real-time monitoring of changes in ...

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    8. Optical inspection of solar cells using phase-sensitive optical coherence tomography

      Optical inspection of solar cells using phase-sensitive optical coherence tomography

      The inspection and measurement of solar cells has become an important technique in evaluating the efficiency and quality of solar cell devices. Currently, surface defect detection of solar cells can be achieved by several approaches such as machine vision, photoluminescence, and electroluminescence imaging techniques. Nevertheless, it is still difficult to inspect the inner structures of solar cells. In response to this need, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) have become common techniques for investigating the nanostructures of solar cells. However, both carry the disadvantages of destructive imaging, high cost, and a small inspection area. Moreover, it is ...

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    9. Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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    10. Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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    11. Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures

      Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures

      In this letter, a phase-sensitive, swept-source optical coherence tomography (SS-OCT) system is implemented for the optical measurement of nanostructures. A new approach is proposed to reduce the phase errors, resulting from trigger jitter of the swept source and the asynchronization between the A-scan trigger and OCT signal at the data acquisition end, with a narrowband fiber Bragg grating to generate the accurate A-scan trigger. Furthermore, combining the common-path configuration with the proposed approach, the displacement sensitivity can be calculated to be 80 pm when the swept source is operated at 30 kHz. Finally, the conducting glass was scanned with the ...

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    12. Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography

      Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography
      This study demonstrates a new approach for evaluating the properties of indium tin oxide (ITO) conducting glass and identifying defects using optical coherence tomography (OCT). A swept-source OCT system was implemented to scan the ITO conducting glass to enable two-dimensional or three-dimensional imaging. With OCT scanning, the defects can be clearly identified at various depths. Several parameters in addition to morphological information can be estimated simultaneously, including the thickness of the glass substrate, the refractive index, reflection coefficient, and transmission coefficient, all of which can be used to evaluate the quality of ITO conducting glass. This study developed a modified ...
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    1-12 of 12
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    1. (11 articles) Chang Gung University
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    Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography Optical inspection of solar cells using phase-sensitive optical coherence tomography Optical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diode Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography Using Optical Coherence Tomography to Identify of Oral Mucosae with 3D-Printing Probe Determination of Coefficient of Thermal Expansion in High Power GaN-Based Light-Emitting Diodes via Optical Coherent Tomography Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy