1. Articles from Jiann-Der Lee

    1-7 of 7
    1. Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was ...

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    2. In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography

      In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography

      Transdermal drug-delivery systems (TDDS) have been a growing field in drug delivery because of their advantages over parenteral and oral administration. Recent studies illustrate that microneedles (MNs) can effectively penetrate through the stratum corneum barrier to facilitate drug delivery. However, the temporal effects on skin and drug diffusion are difficult to investigate in vivo . In this study, we used optical coherence tomography (OCT) to observe the process by which MNs dissolve and to investigate the temporal effects on mouse skin induced by MNs, including the morphological and vascular changes. Moreover, the recovery process of the skin was observed with OCT ...

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    3. Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography

      Focused ultrasound (FUS) can be used to locally and temporally enhance vascular permeability, improving the efficiency of drug delivery from the blood vessels into the surrounding tissue. However, it is difficult to evaluate in real time the effect induced by FUS and to noninvasively observe the permeability enhancement. In this study, speckle-variance optical coherence tomography (SVOCT) was implemented for the investigation of temporal effects on vessels induced by FUS treatment. With OCT scanning, the dynamic change in vessels during FUS exposure can be observed and studied. Moreover, the vascular effects induced by FUS treatment with and without the presence of ...

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    4. Region segmentation in 3-D optical coherence tomography images

      Region segmentation in 3-D optical coherence tomography images

      This paper describes a novel region segmentation method created to enhance spatial relationships in 3-D optical coherence tomography (OCT) images. To reduce the noise and distortion problems in low-resolution OCT images, previous work used the mean value and an enhanced-fuzzy-c-mean algorithm to cluster pixels in 2-D OCT images and find the edge between different clustered regions. To utilize more spatial relationships and to reduce computation time, the proposed method uses the mean value and a 3-D filter-based-fuzzy-c-mean algorithm to cluster pixels in 3-D OCT images and find the edge between different clustered regions. The OCT images of an artificial object ...

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    5. Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography

      Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography

      Focused ultrasound (FUS) is a recently discovered noninvasive technique for local and temporal enhancement of vascular permeability, which facilitates drug delivery from the vessels into the surrounding tissue. However, exposure to FUS at a high intensity may cause permanent damage. To investigate the effects of the FUS treatment on blood vessels, we propose to use fluorescein angiography (FA) and optical coherence tomography (OCT) for real-time observation of the diffusion of fluorescence dye from blood vessels and to evaluate the morphological changes of the vessels in vivo . With time-resolved FA imaging, the relationship between the exposed power and the improved permeability ...

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    6. Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures

      Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures

      In this letter, a phase-sensitive, swept-source optical coherence tomography (SS-OCT) system is implemented for the optical measurement of nanostructures. A new approach is proposed to reduce the phase errors, resulting from trigger jitter of the swept source and the asynchronization between the A-scan trigger and OCT signal at the data acquisition end, with a narrowband fiber Bragg grating to generate the accurate A-scan trigger. Furthermore, combining the common-path configuration with the proposed approach, the displacement sensitivity can be calculated to be 80 pm when the swept source is operated at 30 kHz. Finally, the conducting glass was scanned with the ...

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    7. Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography

      Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography
      This study demonstrates a new approach for evaluating the properties of indium tin oxide (ITO) conducting glass and identifying defects using optical coherence tomography (OCT). A swept-source OCT system was implemented to scan the ITO conducting glass to enable two-dimensional or three-dimensional imaging. With OCT scanning, the defects can be clearly identified at various depths. Several parameters in addition to morphological information can be estimated simultaneously, including the thickness of the glass substrate, the refractive index, reflection coefficient, and transmission coefficient, all of which can be used to evaluate the quality of ITO conducting glass. This study developed a modified ...
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    1-7 of 7
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    Defect detection and property evaluation of indium tin oxide conducting glass using optical coherence tomography Quantitative Phase Imaging With Swept-Source Optical Coherence Tomography for Optical Measurement of Nanostructures Quantitative observation of focused-ultrasound-induced vascular leakage and deformation via fluorescein angiography and optical coherence tomography Region segmentation in 3-D optical coherence tomography images Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography Post-Doctoral and Graduate Student Research Positions at the University of Illinois Urbana-Champaign Multiscale correlation of microvascular changes on optical coherence tomography angiography with retinal sensitivity in diabetic retinopathy Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque PERSONALIZED CHARACTERISTICS OF MORPHOMETRIC AND FUNCTIONAL PARAMETERS OF RETINA IN ARTERIAL HYPERTENTION ACCORDING TO OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY DATA Coherence function-encoded optical palpation