1. Articles from Christophe Dubois

    1-17 of 17
    1. EuOptical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chro

      EuOptical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chro

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

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    2. Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

      Read Full Article
    3. Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chroni

      Aims: The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. Methods and results: The main PRISON IV trial randomised 330 patients to either SES or EES. At nine months, 281 (85%) patients underwent repeat angiography. Of these, 60 consecutive patients received optical coherence tomography divided over both stent groups. The mean number of struts analysed was 750±337 and 633±358 ...

      Read Full Article
    4. Optical coherence tomography-based assessment of bifurcation stenting using the Axxess™ Biolimus A9™-eluting stent system

      Optical coherence tomography-based assessment of bifurcation stenting using the Axxess™ Biolimus A9™-eluting stent system

      Bifurcation lesions are associated with increased procedural complications and worse long-term outcome. Multiple techniques are available, including the dedicated drug-eluting Axxess™ stent system (Biosensors International Ltd., Singapore, Singapore), providing complete bifurcation support without covering the carina. Low rates of restenosis in both main vessel (MV) and side branch (SB) have been demonstrated. High-resolution imaging techniques such as intravascular optical coherence tomography (IV-OCT) may help the positioning and implantation of the Axxess device, as angiographic guidance alone may be insufficient. A Medina 1,1,1 bifurcation lesion was treated using the Axxess device and BioMatrix™ stents (Biosensors International Ltd.) in the ...

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    5. COmplex coronary Bifurcation lesions: RAndomized comparison of a strategy using a dedicated self-expanding biolimus-eluting stent versus a culotte strategy using everolimus-eluting stents: primary results of the COBRA trial

      COmplex coronary Bifurcation lesions: RAndomized comparison of a strategy using a dedicated self-expanding biolimus-eluting stent versus a culotte strategy using everolimus-eluting stents: primary results of the COBRA trial

      Aims: We aimed to compare healing responses with optical coherence tomography, and clinical and angiographic outcome after treatment of coronary bifurcation lesions with a dedicated stent versus aconventional culotte technique. Methods and results: Forty patients with true and complex coronary bifurcation lesions were randomly assigned to treatment with the Axxess™ bifurcation stent in the proximal main vessel (MV) and additional BioMatrix™ stents in the branches (Biosensors Europe SA, Morges, Switzerland), versus a culotte technique using XIENCE™ stents (Abbott Vascular, Santa Clara, CA, USA). The primary endpoint of percentage of uncovered struts at nine months was similar with the dedicated strategy ...

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    6. STACCATO (Assessment of Stent sTrut Apposition and Coverage in Coronary ArTeries with Optical coherence tomography in patients with STEMI, NSTEMI and stable/unstable angina undergoing everolimus vs. biolimus A9-eluting stent implantation): a randomised co

      STACCATO (Assessment of Stent sTrut Apposition and Coverage in Coronary ArTeries with Optical coherence tomography in patients with STEMI, NSTEMI and stable/unstable angina undergoing everolimus vs. biolimus A9-eluting stent implantation): a randomised co

      Aims: To compare tissue coverage in coronary lesions stented with durable fluoropolymer-coated everolimus-eluting stents (EES) vs. biodegradable polymer-coated biolimus A9-eluting stents (BES). Methods and results: Sixty-four patients (64 lesions) with de novo coronary artery lesions were randomised to percutaneous treatment with XIENCE® EES (Abbott Vascular, Santa Clara, CA, USA) vs. BioMatrix™ BES (Biosensors, Morges, Switzerland). The primary endpoint was the percentage of uncovered struts, as assessed with OCT, at nine months. The average percentage of uncovered struts was significantly lower with EES (4.3±4.8% vs. 8.7±7.8% with BES, p=0.019). There was no difference ...

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    7. Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinica

      Optical coherence tomography study of healing characteristics of paclitaxel-eluting balloons vs. everolimus-eluting stents for in-stent restenosis: the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) randomised clinica

      Aims: Little is known about the respective healing responses and clinical efficacy and safety of drug-eluting balloons (DEB) and the second generation of drug-eluting stents (DES) when used to treat in-stent restenosis (ISR). In this study, we set out to compare prospectively the healing characteristics, as assessed by optical coherence tomography (OCT), of DEB versus DES after treatment of ISR in bare metal stents (BMS). Methods and results: Fifty patients with BMS ISR were randomised to treatment with a paclitaxel-eluting balloon vs. an everolimus-eluting stent (EES). The primary endpoint was the percentage of uncovered struts, assessed with OCT at nine ...

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    8. Automated detection and quantification of clusters of malapposed and uncovered intracoronary stent struts assessed with optical coherence tomography

      Automated detection and quantification of clusters of malapposed and uncovered intracoronary stent struts assessed with optical coherence tomography

      To date, accurate quantification and localization of malapposed and uncovered struts needs manual and time consuming analysis of large datasets. To develop an algorithm for automated detection and quantification of clusters of malapposed and uncovered struts in optical coherence tomography (OCT) pullbacks, including comprehensive information about their three-dimensional spatial distribution. 64 lesions in 64 patients treated with drug-eluting stent underwent assessment with OCT immediately after implantation and at 9-month follow-up (55 patients). An automated algorithm was used to detect and quantify stent strut malapposition at baseline and coverage at follow-up on an individual strut level. We subsequently applied an algorithm ...

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    9. Healing course of acute vessel wall injury after drug-eluting stent implantation assessed by optical coherence tomography

      Healing course of acute vessel wall injury after drug-eluting stent implantation assessed by optical coherence tomography

      BACKGROUND: Vessel wall injury after drug-eluting stent (DES) implantation can be characterized in detail by optical coherence tomography (OCT). Little is known about the healing course of these phenomena. METHODS AND RESULTS: In 62 lesions (62 patients), the incidence of acute vessel trauma was assessed in the stented region and the edge segments immediately after DES implantation. The healing course of these injuries was assessed at 9-month OCT follow-up using a software algorithm allowing for reliable spatial comparison of baseline and follow-up cross-sectional images. Tissue prolapse (TP) and tissue protrusions were detected in 81 and 35% of lesions, respectively. A ...

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    10. Provisional side branch stenting: presentation of an automated method allowing online 3D OCT guidance

      Provisional side branch stenting: presentation of an automated method allowing online 3D OCT guidance

      A 58-year-old man with unstable angina underwent percutaneous coronary intervention for a severe stenosis of the mid-left anterior descending artery (LAD), at a bifurcation point with a large diameter diagonal side branch (SB). After predilation with an Emerge 3.0 × 12 mm balloon (Boston Scientific, MA, USA), a 3.0 × 32 mm Promus Element (Boston Scientific) everolimus-eluting stent was implanted in the LAD. Subsequently, proximal post-dilation with a non-compliant (NC) Quantum 3.75 × 8 mm balloon (Boston Scientific) and post-dilation of the stent segment with an NC Quantum 3.0 × 12 mm balloon

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    11. Optical Coherence Tomography Assessment of Coverage of Side Branch Ostium After Implantation of Xience SBA Dedicated Coronary Bifurcation System

      Optical Coherence Tomography Assessment of Coverage of Side Branch Ostium After Implantation of Xience SBA Dedicated Coronary Bifurcation System

      OCT Imaging of the Xience SBA Coronary Bifurcation Stent (A) A cross-section at the entry of the side branch (SB) shows proper strut apposition and optimal scaffolding of the ostium. (B) At the level of the carina, fully apposed stent struts properly span the width of the bifurcation core. From 4 to 8 o'clock, a calcified plaque is visible. (C) In the proximal main vessel (MV), all struts are well-apposed. (D) Three-dimensional optical coherence tomography (OCT)–based reconstruction of the stent. There is optimal scaffolding of the SB ostium with no free floating struts. (E) Simultaneous double balloon inflation ...

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    12. Automatic three-dimensional registration of intravascular optical coherence tomography images

      Automatic three-dimensional registration of intravascular optical coherence tomography images

      Intravascular optical coherence tomography (IV-OCT) is a catheter-based high-resolution imaging technique able to visualize the inner wall of the coronary arteries and implanted devices in vivo with an axial resolution below 20 μm. IV-OCT is being used in several clinical trials aiming to quantify the vessel response to stent implantation over time. However, stent analysis is currently performed manually and corresponding images taken at different time points are matched through a very labor-intensive and subjective procedure. We present an automated method for the spatial registration of IV-OCT datasets. Stent struts are segmented through consecutive images and three-dimensional models of the ...

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    13. Automatic three-dimensional registration of intra-vascular optical coherence tomography images for the clinical evaluation of stent implantation over time

      Automatic three-dimensional registration of intra-vascular optical coherence tomography images for the clinical evaluation of stent implantation over time

      In the last decade a large number of new intracoronary devices (i.e. drug-eluting stents, DES) have been developed to reduce the risks related to bare metal stent (BMS) implantation. The use of this new generation of DES has been shown to substantially reduce, compared with BMS, the occurrence of restenosis and recurrent ischemia that would necessitate a second revascularization procedure. Nevertheless, safety issues on the use of DES persist and full understanding of mechanisms of adverse clinical events is still a matter of concern and debate. Intravascular Optical Coherence Tomography (IV-OCT) is an imaging technique able to visualize the ...

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    14. Congratulations to Giovanni Ughi from K. U. Leuven a Winner of a 2012 Student Travel Grant Award

      Congratulations to Giovanni Ughi from K. U. Leuven a Winner of a 2012 Student Travel Grant Award

      Giovanni Ughi from the Catholic University Leuven is one of four winners of the OCT News 2012 student travel grant awards (see prior announcement Here). Below is a summary of his work. Topic covered by the project is software development for quantitative computer aided automated analysis of intra-vascular OCT images. Automated segmentation of stent struts and lumen, stent apposition, stent coverage and registration of IV-OCT datasets at different instants of times are part of the software research and development. Moreover, tissue characterization to automatically assess atherosclerotic plaques components and morphology are other issues at which the project address. The optical ...

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    15. Optical coherence tomography (OCT) in PCI for in-stent restenosis (ISR): rationale and design of the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) study

      Optical coherence tomography (OCT) in PCI for in-stent restenosis (ISR): rationale and design of the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) study
      The optimal treatment of bare metal stent restenosis is still not defined. The most employed contemporary option is the implantation of a drug-eluding stent (DES). However, this procedure implies the addition of a second metal layer in the vessel wall, which is linked to delayed healing.
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    16. Automated volumetric stent analysis of in-vivo intracoronary optical coherence tomography three-dimensional datasets

      Automated volumetric stent analysis of in-vivo intracoronary optical coherence tomography three-dimensional datasets
      Intra-vascular Optical Coherence Tomography (IV-OCT) is an appropriate imaging modality for the evaluation of stent struts apposition and coverage in the coronary arteries. Most often, image analysis is performed by a time-consuming manual contour tracing process. Recently, we proposed an algorithm for fully automated lumen morphology and individual stent struts apposition/coverage quantification. In this manuscript further developments allowing for automatic segmentation of the stent contour are presented. As such, quantification of in-stent area, malapposition cross-sectional area (i.e. the area representing the space from the stent surface to the vessel wall) and coverage cross-sectional area (i.e. the area ...
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    17. Automated stent strut coverage and apposition analysis of in-vivo intra coronary optical coherence tomography images

      Automated stent strut coverage and apposition analysis of in-vivo intra coronary optical coherence tomography images
      Several studies have proven that intra-vascular OCT is an appropriate imaging modality able to evaluate stent strut apposition and coverage in coronary arteries. Currently image processing is performed manually resulting in a very time consuming and labor intensive procedure. We propose an algorithm for fully automatic individual stent strut apposition and coverage analysis in coronary arteries. The vessel lumen and stent strut are automatically detected and segmented through analysis of the intensity profiles of the A-scan lines. From these data, apposition and coverage can then be estimated automatically. The algorithm was validated using manual measurement (performed by two trained cardiologists ...
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    1-17 of 17
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    1. (17 articles) K. U. Leuven
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    Automated stent strut coverage and apposition analysis of in-vivo intra coronary optical coherence tomography images Automated volumetric stent analysis of in-vivo intracoronary optical coherence tomography three-dimensional datasets Optical coherence tomography (OCT) in PCI for in-stent restenosis (ISR): rationale and design of the SEDUCE (Safety and Efficacy of a Drug elUting balloon in Coronary artery rEstenosis) study Congratulations to Giovanni Ughi from K. U. Leuven a Winner of a 2012 Student Travel Grant Award Automatic three-dimensional registration of intra-vascular optical coherence tomography images for the clinical evaluation of stent implantation over time Automatic three-dimensional registration of intravascular optical coherence tomography images Optical Coherence Tomography Assessment of Coverage of Side Branch Ostium After Implantation of Xience SBA Dedicated Coronary Bifurcation System Provisional side branch stenting: presentation of an automated method allowing online 3D OCT guidance STACCATO (Assessment of Stent sTrut Apposition and Coverage in Coronary ArTeries with Optical coherence tomography in patients with STEMI, NSTEMI and stable/unstable angina undergoing everolimus vs. biolimus A9-eluting stent implantation): a randomised co COmplex coronary Bifurcation lesions: RAndomized comparison of a strategy using a dedicated self-expanding biolimus-eluting stent versus a culotte strategy using everolimus-eluting stents: primary results of the COBRA trial ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD) Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I