1. Articles from Sylvain Gigan

    1-2 of 2
    1. Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy

      Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy
      Myelin sheath disruption is responsible for multiple neuropathies in the central and peripheral nervous system. Myelin imaging has thus become an important diagnosis tool. However, in vivo imaging has been limited to either low-resolution techniques unable to resolve individual fibers or to low-penetration imaging of single fibers, which cannot provide quantitative information about large volumes of tissue, as required for diagnostic purposes. Here, we perform myelin imaging without labeling and at micron-scale resolution with >300-μm penetration depth on living rodents. This was achieved with a prototype [termed deep optical coherence microscopy (deep-OCM)] of a high-numerical aperture infrared full-field optical coherence ...
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    2. Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy

      Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy
      Two-photon laser scanning microscopy (2PLSM) is an important tool for in vivo tissue imaging with sub-cellular resolution, but the penetration depth of current systems is potentially limited by sample-induced optical aberrations. To quantify these, we measured the refractive index n' in the somatosensory cortex of 7 rats in vivo using defocus optimization in full-field optical coherence tomography (ff-OCT). We found n' to be independent of imaging depth or rat age. From these measurements, we calculated that two-photon imaging beyond 200µm into the cortex is limited by spherical aberration, indicating that adaptive optics will improve imaging depth.
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    1-2 of 2
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    Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact In vivo imaging of melanoma-implanted magnetic nanoparticles using contrast-enhanced magneto-motive optical Doppler tomography Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements Tunable Emission Wavelength Stacked InAs/GaAs Quantum Dots by Chemical Beam Epitaxy for Optical Coherence Tomography Study of clinical significance of optical coherence tomography in diagnosis & management of diabetic macular edema Highmark Health’s VITAL Program to Evaluate Avinger’s Novel Treatment for Peripheral Artery Disease Image registration, averaging, and compounding for high speed extended depth optical coherence tomography Interferometry employing refractive index dispersion broadening of interference signals Angiographically intermediate left main bifurcation disease assessment by frequency domain optical coherence tomography (FD-OCT) Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging