1. Articles from Sylvain Gigan

    1-2 of 2
    1. Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy

      Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy
      Myelin sheath disruption is responsible for multiple neuropathies in the central and peripheral nervous system. Myelin imaging has thus become an important diagnosis tool. However, in vivo imaging has been limited to either low-resolution techniques unable to resolve individual fibers or to low-penetration imaging of single fibers, which cannot provide quantitative information about large volumes of tissue, as required for diagnostic purposes. Here, we perform myelin imaging without labeling and at micron-scale resolution with >300-μm penetration depth on living rodents. This was achieved with a prototype [termed deep optical coherence microscopy (deep-OCM)] of a high-numerical aperture infrared full-field optical coherence ...
      Read Full Article
    2. Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy

      Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy
      Two-photon laser scanning microscopy (2PLSM) is an important tool for in vivo tissue imaging with sub-cellular resolution, but the penetration depth of current systems is potentially limited by sample-induced optical aberrations. To quantify these, we measured the refractive index n' in the somatosensory cortex of 7 rats in vivo using defocus optimization in full-field optical coherence tomography (ff-OCT). We found n' to be independent of imaging depth or rat age. From these measurements, we calculated that two-photon imaging beyond 200µm into the cortex is limited by spherical aberration, indicating that adaptive optics will improve imaging depth.
      Read Full Article
    1-2 of 2
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (2 articles) ESPCI ParisTech
    2. (2 articles) Claude Boccara
    3. (1 articles) UCSF
    4. (1 articles) University of Waterloo
    5. (1 articles) University of Manchester
    6. (1 articles) University of Toronto
    7. (1 articles) David Huang
    8. (1 articles) Nikola Krstajic
    9. (1 articles) Pete H. Tomlins
    10. (1 articles) Optovue
    11. (1 articles) Carl Zeiss Meditec
    12. (1 articles) Heidelberg Spectralis
  3. Popular Articles

  4. Picture Gallery

    Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy Difference of GCIPL Thickness of Diabetes and Normal Eyes in Spectral Domain OCT Iterative Nonlocal Means Method for Despeckling Optical Coherence Tomography Images Foveal Shape According to Age and Gender Using Spectral Domain Optical Coherence Tomography Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014 In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging Variability and Repeatability of Quantitative, Fourier Domain-OCT Doppler Blood Flow in Young and Elderly Healthy Subjects Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts MedLumics Introduces NITID Skin Imaging System at EADV COMBINED HAMARTOMA OF THE RETINA AND RETINAL PIGMENT EPITHELIUM: Findings on Enhanced Depth Imaging Optical Coherence Tomography in Eight Eyes