1. Articles from Shu-Wei Huang

    1-7 of 7
    1. Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy

      Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy
      Optical coherence microscopy (OCM) is a promising technology for high-resolution cellular-level imaging in human tissues. Line-scanning OCM is a new form of OCM that utilizes line-field illumination for parallel detection. In this study, we demonstrate improved detection sensitivity by using an achromatic design for line-field generation. This system operates at 830-nm wavelength with 82-nm bandwidth. The measured axial resolution is 3.9 $mu$m in air (corresponding to $sim$2.9 $mu$m in tissue), and the transverse resolutions are 2.1 $mu$m along the line-field illumination direction and 1.7 $mu$m perpendicular to line illumination direction. The ...
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    2. Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography

      Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography
      Most of the colorectal cancer has grown from the adenomatous polyp. Adenomatous lesions have a well-documented relationship to colorectal cancer in previous studies. Thus, to detect the morphological changes between polyp and tumor can allow early diagnosis of colorectal cancer and simultaneous removal of lesions. OCT (Optical coherence tomography) has been several advantages including high resolution and non-invasive cross-sectional image in vivo. In this study, we investigated the relationship between the B-scan OCT image features and histology of malignant human colorectal tissues, also en-face OCT image and the endoscopic image pattern. The in-vitro experiments were performed by a swept-source optical ...
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    3. High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe

      High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
      ical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly optimization of ...
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    4. New technologies for optical coherence microscopy (Thesis)

      New technologies for optical coherence microscopy (Thesis)
      According to the American Cancer Society, gastrointestinal (GI) cancers are among the most common forms of malignancies suffered today, affecting -200,000 people and causing -80,000 deaths in the United States every year. The prognosis depends heavily on the detection of early-stage lesions. The process of endoscopic surveillance, excisional biopsy, and histologic examination is the current gold standard for screening and diagnosis of many GI cancers. This process, however, is invasive, time-consuming, and can suffer from unacceptable false negative rates. Optical imaging technology that provides real-time, high-resolution imaging of human tissue in vivo with resolution at or near that ...
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    5. Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography

      Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography
      The detection of a gold nanoparticle contrast agent is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography (OCT). A focused beam from a laser diode at 808 nm is modulated at frequencies of 500 Hz – 60 kHz while irradiating a solution ... [Opt. Express 16, 4376-4393 (2008)]
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    6. High-resolution optical coherence tomography imaging of the living kidney

      Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can provide non-invasive, cross-sectional, high-resolution images of tissue morphology in situ and in real-time. In the present series of studies, we used a high-speed OCT imaging system equipped with a frequency-swept laser light source (1.3 m wavelength) to study living kidneys in situ. Adult, male Munich–Wistar rats were anesthetized, a laparotomy was performed and the living kidneys were exposed for in situ observation. We observed the kidneys prior to, during and following exposure to renal ischemia induced by clamping the renal artery. The effects of intravenous mannitol ...
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    7. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Yu Chen, Aaron D. Aguirre, Pei-Lin Hsiung, Shu-Wei Huang, Hiroshi Mashimo, Joseph M. Schmitt, James G. Fujimoto. Optical coherence tomography (OCT) is an emerging medical imaging technology which generates high resolution, cross-sectional images in situ, without the need for excisional biopsy. Previous clinical studies using endoscopic OCT with standard 10-15 μm axial resolution have demonstrated its ... [Opt. Express 16, 2469-2485 (2008)]

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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) Shu-Wei Huang
    2. (6 articles) Massachusetts Institute of Technology
    3. (6 articles) James G. Fujimoto
    4. (3 articles) Yu Chen
    5. (2 articles) University of Maryland
    6. (2 articles) Ludwig Maximilian University of Munich
    7. (2 articles) Robert A. Huber
    8. (2 articles) Aaron D. Aguirre
    9. (2 articles) Chao Zhou
    10. (2 articles) Desmond C. Adler
    11. (1 articles) University of Sydney
    12. (1 articles) University of Zurich
    13. (1 articles) UCSD
    14. (1 articles) University of Pittsburgh
    15. (1 articles) L V Prasad Eye Institute
    16. (1 articles) Giuseppe Querques
    17. (1 articles) Carl Zeiss Meditec
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    Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography New technologies for optical coherence microscopy (Thesis) High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography Improved Detection Sensitivity of Line-Scanning Optical Coherence Microscopy Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review Retinal microvascular metrics in untreated essential hypertensives using optical coherence tomography angiography Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: Long term study Reorganization of the perifoveal microvasculature after macular hole closure assessed via optical coherence tomography angiography Optical coherence tomography angiography (OCTA) findings in Serpiginous Choroiditis Changes in retinal layer thickness with maturation in the dog: an in vivo spectral domain - optical coherence tomography imaging study