1. Articles from Michael F. Chiang

    1-9 of 9
    1. Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device

      Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device

      Optical coherence tomography (OCT) has changed the standard of care for diagnosis and management of macular diseases in adults. Current commercially available OCT systems, including handheld OCT for pediatric use, have a relatively narrow field of view (FOV), which has limited the potential application of OCT to retinal diseases with primarily peripheral pathology, including many of the most common pediatric retinal conditions. More broadly, diagnosis of all types of retinal detachment (exudative, tractional, and rhegmatogenous) may be improved with OCT-based assessment of retinal breaks, identification of proliferative vitreoretinopathy (PVR) membranes, and the pattern of subretinal fluid. Intraocular tumors both benign ...

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    2. Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity

      Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity

      Objective: To determine whether handheld widefield optical coherence tomography (OCT) can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views. Design: Prospective observational study. Participants: Consecutive neonates admitted to the neonatal intensive care unit (NICU) in a single academic medical center who also met criteria for ROP screening and consented for research imaging. Methods: Scleral depression was combined with widefield OCT using an investigational 400-kHz, 55-degree field of view handheld OCT during routine ROP screening from October 28, 2020 to March 03, 2021. Main outcome measures: Acquisition of en face and B-scan ...

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    3. Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity

      Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity

      Recent advances in portable optical coherence tomography (OCT) and OCT angiography (OCTA) have resulted in wider fields of view (FOV) and shorter capture times, further expanding the potential clinical role of OCT technology in the diagnosis and management of retinopathy of prematurity (ROP). Using a prototype, handheld OCT device, retinal imaging was obtained in non-sedated infants in the neonatal intensive care unit (NICU) as well as sedated infants in the operating room of Oregon Health & Science University (OHSU) Hospital. In this observational study, we provide an overview of potential advantages of OCT-based disease assessment in ROP. We observed that next-generation ...

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    4. 105° field of view non-contact handheld swept-source optical coherence tomography

      105° field of view non-contact handheld swept-source optical coherence tomography

      We demonstrate a handheld swept-source optical coherence tomography (OCT) system with a 400 kHz vertical-cavity surface-emitting laser (VCSEL) light source, a non-contact approach, and an unprecedented single shot 105° field of view (FOV). We also implemented a spiral scanning pattern allowing real-time visualization with improved scanning efficiency. To the best of our knowledge, this is the widest FOV achieved in a portable non-contact OCT retinal imaging system to date. Improvements to the FOV may aid the evaluation of retinal diseases such as retinopathy of prematurity, where important vitreoretinal changes often occur in the peripheral retina.

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    5. Prospective evaluation of optical coherence tomography for disease detection in the Casey mobile eye clinic

      Prospective evaluation of optical coherence tomography for disease detection in the Casey mobile eye clinic

      This study was designed to evaluate iVue Spectral-domain optical coherence tomography (SD-OCT) effectiveness in screening for eye disease compared to clinical examination. Subjects were recruited from the Casey Eye Community Outreach Program Mobile Clinic during its routinely scheduled outreach clinics to indigent, underserved populations throughout Oregon. Macular optical coherence tomography interpretation and automated optical coherence tomography analysis were compared to the clinical examination, with specific attention to findings indicative of retinal abnormalities, risks for glaucoma, and narrow angles. As a result, a total of 114 subjects were included in this study. In diabetics, optical coherence tomography and clinical exam were ...

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    6. High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high-quality OCT/OCTA images, particularly with the handheld system, since both the operator hand tremor and subject motion can cause significant motion artifacts. In addition, having a large field of view and the ability of real-time data visualization are critical elements in rapid disease ...

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    7. Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Importance Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultra–wide-field OCT or OCTA images in neonates. Objective To obtain ultra–wide-field OCT and OCTA images in neonates with ROP using a prototype handheld OCT and OCTA device. Design, Setting, and Participants This observational case series was conducted ...

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    8. Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients with a History of Retinopathy of Prematurity

      Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients with a History of Retinopathy of Prematurity

      Purpose To evaluate retinal anatomy and segmentation errors from spectral domain optical coherence tomography (SD-OCT) imaging (MM5 protocol of RTVue-100; Optovue, Inc., Fremont, CA) in school-aged children. Design A prospective cohort study in a referral medical center. Methods 133 eyes of 133 patients were enrolled. Patients were grouped as those who were treated for retinopathy of prematurity (ROP) (ROP-Tx-group); those with spontaneously-regressed ROP (ROP-non-Tx-group); other premature patients (premature group); and full-term age-matched children (full-term group). Anatomy and segmentation errors of retina were evaluated by SD-OCT. Results The mean age at assessment was 9.5 years (range 4–16 years). The ...

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      Mentions: Visionix
    9. Applying newer technology to your practice in pediatric ophthalmology and strabismus

      Applying newer technology to your practice in pediatric ophthalmology and strabismus
      Relevance: Imaging modalities like optical coherence tomography enable us to view and document details of ocular anatomy. These tools which are commonly used by our colleagues in cornea, glaucoma and retina, should be incorporated in the pediatric ophthalmology practice. Posterior segment OCT can be used to objectively monitor children with glaucoma, measure RNFL changes in papilledema or optic atrophy, study foveal morphology in diseases like retinoschisis. Anterior segment OCT can be used to assess anterior chamber depth, measure white-to-white distance, document the thickness of both the ciliary body and lens in children with anterior segment abnormalities. Newer technology now allow ...
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    1-9 of 9
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  2. Topics in the News

    1. (7 articles) Oregon Health & Science University
    2. (6 articles) Center for Ophthalmic Optics and Lasers
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    Applying newer technology to your practice in pediatric ophthalmology and strabismus Outer Retinal Structural Alternation and Segmentation Errors in Optical Coherence Tomography Imaging in Patients with a History of Retinopathy of Prematurity Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source Prospective evaluation of optical coherence tomography for disease detection in the Casey mobile eye clinic 105° field of view non-contact handheld swept-source optical coherence tomography Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging Optical Coherence Tomography Findings in Choroidal Melanoma-Associated Subretinal Fluid Evaluation of retinal vessel and perfusion density in migraine patients by optical coherence tomography angiography