All Articles from Yu Chen -Optical Coherence Tomography News

Articles from Yu Chen

1-24 of 84 1 2 3 4 »
1. Normative Data and Conversion Equation for Spectral-Domain Optical Coherence Tomography in an International Healthy Control Cohort
  
  Explore LWW Online Sep 2 2022 Ophthalmology
  
  Background: Spectral-domain (SD-) optical coherence tomography (OCT) can reliably measure axonal (peripapillary retinal nerve fiber layer [pRNFL]) and neuronal (macular ganglion cell + inner plexiform layer [GCIPL]) thinning in the retina. Measurements from 2 commonly used SD-OCT devices are often pooled together in multiple sclerosis (MS) studies and clinical trials despite software and segmentation algorithm differences; however, individual pRNFL and GCIPL thickness measurements are not interchangeable between devices. In some circumstances, such as in the absence of a consistent OCT segmentation algorithm across platforms, a conversion equation to transform measurements between devices may be useful to facilitate pooling of data. The ...
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  Mentions: University College London Oregon Health & Science University Academic Medical Center at the University of Amsterdam
2. Feasibility of the soft attention-based models for automatic segmentation of OCT kidney images
  
  Explore Optica Publishing Group Jul 4 2022 Urology
  
  Clinically, optical coherence tomography (OCT) has been utilized to obtain the images of the kidney's proximal convoluted tubules (PCTs), which can be used to quantify the morphometric parameters such as tubular density and diameter. Such parameters are useful for evaluating the status of the donor kidney for transplant. Quantifying PCTs from OCT images by human readers is a time-consuming and tedious process. Despite the fact that conventional deep learning models such as conventional neural networks (CNNs) have achieved great success in the automatic segmentation of kidney OCT images, gaps remain regarding the segmentation accuracy and reliability. Attention-based deep learning ...
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3. The Role of Optical Coherence Tomography Criteria and Machine Learning in Multiple Sclerosis and Optic Neuritis Diagnosis
  
  Explore Neurology Jul 1 2022 Neurology , Ophthalmology
  
  Background and objectives: Recent studies have suggested that inter-eye differences (IEDs) in peripapillary retinal nerve fiber layer (pRNFL) or ganglion cell+inner plexiform (GCIPL) thickness by spectral-domain optical coherence tomography (SD-OCT) may identify people with a history of unilateral optic neuritis (ON). However, this requires further validation. Machine learning classification may be useful for validating thresholds for OCT IEDs and for examining added utility for visual function tests, such as low-contrast letter acuity (LCLA), in the diagnosis of people with multiple sclerosis (PwMS) and for unilateral ON history. Methods: Participants were from 11 sites within the International Multiple Sclerosis Visual ...
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  Mentions: Johns Hopkins University University College London UC Irvine
4. Digital Gonioscopy based on Three-dimensional Anterior Segment Optical Coherence Tomography: an international multicenter study
  
  Explore Ophthalmology Oct 8 2021 Ophthalmology
  
  Objective: To develop and evaluate the performance of a three-dimensional deep-learning based automated digital gonioscopy system (3D DGS) in detecting two major characteristics in eyes suspected to have primary angle closure glaucoma (PACG): 1) narrow iridocorneal angles (static gonioscopy, Task I) and; 2) peripheral anterior synechiae (PAS) (dynamic gonioscopy, Task II) on optical coherence tomography scans. Design: International cross-sectional multicentre study. Subjects: A total of 1.112 million images of 8694 volume scans (2294 patients) from three centers were included in this study (Task I: training/internal validation/external testing - 4515, 1101, 2222 volume scans respectively; Task II: training/internal ...
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  Mentions: Sun Yat-Sen University
5. Indoor localization of hand-held OCT probe using visual odometry and real-time segmentation using deep learning
  
  Explore IEEE Xplore Oct 3 2021
  
  Objective: Optical coherence tomography (OCT) is an established medical imaging modality that has found widespread use due to its ability to visualize tissue structures at a high resolution. Currently, OCT hand-held imaging probes lack positional information, making it difficult or even impossible to link a specific image to the location it was originally obtained. In this study, we propose a camera-based localization method to track and record the scanner position in real-time, as well as providing a deep learning-based segmentation method. Methods: We used camera-based visual odometry (VO) and simultaneous mapping and localization (SLAM) to compute and visualize the location ...
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  Mentions: University of Maryland The Ohio State University
6. Airway remodeling and bronchodilator responses in asthma assessed by endobronchial optical coherence tomography
  
  Explore Wiley Online Library Aug 28 2021 Pulmonology
  
  LETTER TO THE EDITOR
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7. Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT)
  
  Explore OSA | OSA Publishing Mar 6 2021
  
  Near-infrared (NIR) photoimmunotherapy (NIR-PIT) is an emerging cancer therapy based on a monoclonal antibody and phthalocyanine dye conjugate. Direct tumor necrosis and immunogenic cell death occur during NIR irradiation. However, the alteration of tumor blood vessels and blood volume inside the blood vessels induced by the NIR-PIT process is still unknown. In our study, a speckle variance (SV) algorithm combined with optical coherence tomography (OCT) technology was applied to monitor the change of blood vessels and the alterations of the blood volume inside the blood vessels during and after NIR-PIT treatment. Vascular density and the measurable diameter of the lumen ...
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  Mentions: University of Maryland Fujian Normal University
8. Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study
  
  Explore IOVS Journal Jan 29 2021 Ophthalmology
  
  Purpose : To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. Methods : In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3- × 3-mm centered at the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, and vessel density (VD) in both the superficial (SCP) and deep capillary plexuses (DCP) were measured. The rate of change in macular OCTA metrics over ...
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  Mentions: Sun Yat-Sen University
9. Optical coherence tomography (OCT) system with improved image quality
  
  Explore uspto.gov Dec 8 2020 Patents
  
  This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system that generates an image with improved quality. In one example, the OCT system may generate an improved Bscan image by using multiple shaping functions to shape the raw A-scans. In another example, the OCT system may generate the improved B-scan image by forming multiple apodization patterns on a detector and acquiring raw A-scans by using the apodization patterns. A better diagnosis of a health condition may be reached by using the improved images generated by the OCT system of this disclosure.
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  Mentions: University of Southern California
10. Evaluation of the normal airway morphology using optical coherence tomography
  
  Explore CHEST Jul 6 2019 Pulmonology
  
  Background The anatomical location of small airways, the distribution of airway cartilage and their correlation with ageing have not been well elucidated. Objective To explore the morphological characteristics of small airways in vivo , and how airway structural changes correlate with age using endobronchial optical coherence tomography (EB-OCT). Methods We recruited 112 subjects with peripheral pulmonary nodules. Participants underwent computed tomography, spirometry, and EB-OCT measurements. We measured the airway internal diamaeter (D mean ), inner area (Ai), airway wall area percentage (Aw%) and the thickness of airway cartilage. EB-OCT airway structural characteristics at different age intervals were analyzed, and the association between ...
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11. PhD Student and Postdoctoral Associate Positions at the University of Massachusetts
  
  Explore Optical Coherence Tomography News Jun 24 2019 Jobs & Studentships
  
  We are looking for highly motivated individuals to join the Biophotonics Imaging Laboratory at UMass Amherst and Worcester. Our lab has interdisciplinary biomedical engineering research programs focusing on the development of novel optical imaging methods for biomedical applications, including functional neuroimaging, early cancer detection, transplant organ evaluation, and tissue engineering. Our optical imaging technologies include optical coherence tomography (OCT), multi-photon microscopy (MPM), fluorescence molecular imaging (FMI), laminar optical tomography (LOT), and endoscopy. A detailed description of our research can be found at: http://blog.umd.edu/biophotonics/research/ Candidates with experiences on biomedical engineering, optical engineering, and/or electrical/mechanical ...
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  Mentions: University of Illinois at Urbana-Champaign
12. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD
  
  Explore Medical Journals Publisher Oct 1 2018 Pulmonology
  
  Background: Spirometry confers limited value for identifying small-airway disorders (SADs) in early-stage COPD, which can be detected with impulse oscillometry (IOS) and endobronchial optical coherence tomography (EB-OCT). Whether IOS is useful for reflecting small-airway morphological abnormalities in COPD remains unclear. Objectives: To compare the diagnostic value of spirometry and IOS for identifying SADs in heavy-smokers and COPD based on the objective assessment with EB-OCT. Methods: We recruited 59 COPD patients (stage I, n=17; stage II, n=18; stage III–IV, n=24), 26 heavy-smokers and 21 never-smokers. Assessments of clinical characteristics, spirometry, IOS and EB-OCT were performed. Receiver operation ...
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13. Depth-resolved mapping of muscular bundles in myocardium pulmonary junction using optical coherence tomography
  
  Explore SPIE Digital Library Jul 12 2018 Cardiology
  
  Atrial fibrillation (AF) is the most common cardiac arrhythmia and has high patient morbidity. One of the root causes of AF is initiating triggers from atrial myocardium extending into the pulmonary veins. Visualizing the muscular bundles of myocardial extension is essential to guide the catheter radio-frequency ablation and confirm the curative tissue necrosis thereafter. We applied optical coherence tomography (OCT) for direct visualization of cardial muscle extension in myocardium pulmonary junction. Two perspectives (cross-sectional and en face images) are presented for imaging myocardial extensions. The results demonstrated that cross-sectional images can quickly locate the myocardium pulmonary junction. And en face ...
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  Mentions: University of Maryland Fujian Normal University
14. 3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo
  
  Explore ScienceDirect Apr 26 2018
  
  As a novel low-side-effect cancer therapy, photo-immunotherapy (PIT) is based on conjugating monoclonal antibody (mAb) with a near-infrared (NIR) phthalocyanine dye IRDye700DX (IR 700). IR700 is not only fluorescent to be used as an imaging agent, but also phototoxic. When illuminating with NIR light, PIT can induce highly-selective cancer cell death while leaving most of tumor blood vessels unharmed, leading to an effect termed super-enhanced permeability and retention (SUPR), which can significantly improve the effectiveness of anti-cancer drug. Currently, the therapeutic effects of PIT are monitored using 2D macroscopic fluorescence reflectance imager, which lacks the resolution and depth information to ...
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  Mentions: University of Maryland FDA
15. Optical coherence tomography and computer-aided diagnosis of a murine model of chronic kidney disease
  
  Explore SPIE Digital Library Dec 5 2017 Urology
  
  Chronic kidney disease (CKD) is characterized by a progressive loss of renal function over time. Histopathological analysis of the condition of glomeruli and the proximal convolutional tubules over time can provide valuable insights into the progression of CKD. Optical coherence tomography (OCT) is a technology that can analyze the microscopic structures of a kidney in a nondestructive manner. Recently, we have shown that OCT can provide real-time imaging of kidney microstructures in vivo without administering exogenous contrast agents. A murine model of CKD induced by intravenous Adriamycin (ADR) injection is evaluated by OCT. OCT images of the rat kidneys have ...
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  Mentions: University of Maryland
16. Multi-shaping technique reduces sidelobe magnitude in optical coherence tomography
  
  Explore OSA | OSA Publishing Nov 15 2017
  
  Shaping methods that are commonly used in Fourier-domain optical coherence tomography (FD-OCT) can suppress sidelobe artifacts in the axial direction, but they typically broaden the mainlobe of the point spread function (PSF) and reduce the axial resolution. To improve OCT image quality without this tradeoff, we have developed a multi-shaping technique that reduces the axial sidelobe magnitude dramatically and achieves better axial resolution than conventional shaping methods. This technique is robust and compatible in various FD-OCT imaging systems. Testing of multi-shaping in three experimental settings shows that it reduced the axial sidelobe contribution by more than 8 dB and improved ...
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  Mentions: UCLA
17. Monitoring Kidney Microanatomy Changes During Ischemia-Reperfusion Process Using Texture Analysis of OCT Images
  
  Explore IEEE Xplore Nov 15 2017 Urology
  
  Impact Statement: Tubular diameter has been developed previously as a potential biomarker for the transplant kidney. However, the tubular lumens were segmented out based on an empirically-determined threshold. In our study, a fully automatic texture analysis algorithm has been developed for OCT image analysis of kidney microanatomy during ischemia-reperfusion process. Our method can potentially be applicable in evaluating the status of donor kidneys prior to and after their transplantation. Abstract: Kidney ischemia-reperfusion (I/R) accounts for the majority of acute kidney injury cases, whose consequences are commonly encountered after kidney transplantation. Optical coherence tomography (OCT) has been applied to image ...
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  Mentions: University of Maryland
18. Postdoctoral Fellow, Bioengineering at University of Maryland - College Park
  
  Explore Optical Coherence Tomography News Aug 16 2017 Jobs & Studentships
  
  We are seeking a postdoctoral fellow to pursue research on developing novel optical imaging devices and applications on cancer diagnosis, functional brain imaging and tissue engineering. Candidates must hold a Ph.D. in engineering, physics, or related fields and have prior experience with Optics, OCT, Microscopy (e.g. fluorescence, confocal, Two-photon), and image analysis software development. Experience with cell culture and/or animals experiments is a plus. Please submit a cover letter with a brief description of research experience, interests, and career goals (≤ 2 pages), CV with complete list of publications, and contact information for 3 references in a single ...
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  Mentions: University of Maryland
19. 3D in vivo imaging with extended-focus optical coherence microscopy
  
  Explore Wiley Online Library Apr 25 2017
  
  Optical coherence microscopy (OCM) has unique advantages of non-invasive 3D imaging without the need of exogenous labels for studying biological samples. However, the imaging depth of this technique is limited by the tradeoff between the depth of focus (DOF) and high lateral resolution in Gaussian optics. To overcome this limitation, we have developed an extended-focus OCM (xf-OCM) imaging system using quasi-Bessel beam illumination to extend the DOF to ∼100 μm, about 3-fold greater than standard OCM. High lateral resolution of 1.6 μm ensured detailed identification of structures within live animal samples. The insensitivity to spherical aberrations strengthened the capability ...
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  Mentions: University of Southern California
20. Optical coherence microscopy with extended focus for in vivo embryonic imaging
  
  Explore Conference Proceedings Feb 16 2017 Developmental Biology , Microscopy
  
  Optical coherence microscopy (OCM) has unique advantages of high-resolution volumetric imaging without relying on exogenous labels or dyes. It combines the coherence-gated depth discrimination of optical coherence tomography (OCT) with the high lateral resolution of confocal microscopy, offering an excellent balance between the resolutions and imaging depth. However, as the lateral resolution becomes higher, the imaging depth of OCM decreases and its three-dimensional imaging capability is greatly degraded. To overcome this limitation, we used amplitude apodization to create quasi-Bessel beam illumination in order to extend the depth of focus. The lateral and axial resolutions of our OCM system were measured ...
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  Mentions: University of Southern California
21. Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos
  
  Explore SPIE | Journal Jan 3 2017 Developmental Biology
  
  A phase variance optical coherence microscope (pvOCM) has been created to image blood flow in the microvasculature of zebrafish embryos, without the use of exogenous labels. The pvOCM imaging system has axial and lateral resolutions of 2.8 μ m 2.8 μm in tissue and imaging depth of more than 100 μ m 100 μm . Images of 2 to 5 days postfertilization zebrafish embryos identified the detailed anatomical structure based on OCM intensity contrast. Phase variance contrast offered visualization of blood flow in the arteries, veins, and capillaries. The pvOCM images of the vasculature were confirmed by direct comparisons with fluorescence ...
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  Mentions: University of Southern California
22. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
  
  Explore OSA | OSA Publishing Dec 27 2016 Gastroenterology
  
  Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...
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  Mentions: University of Maryland University of Rochester Harvard University
23. Imaging Spinal Structures With Polarization-Sensitive Optical Coherence Tomography
  
  Explore IEEE Xplore Sep 27 2016 Neurology
  
  Impact Statement: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura, and spinal cord in a piglet model. The PS-OCT can provide enhanced contrast characteristic structures compared to the intensity OCT; therefore it has the potential for guidance in spine interventional procedures. Abstract: We investigate polarization-sensitive optical coherence tomography (PS-OCT) to obtain both intensity and polarization contrast images of in vivo and ex vivo spinal structures like subcutaneous fat, supraspinous ligament, interspinous ligament, ligamentum flavum, dura ...
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  Mentions: University of Maryland Fujian Normal University Tianjin University
24. Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography
  
  Explore ScienceDirect Aug 16 2016 Pulmonology
  
  Background Although forced expiratory volume in one second (FEV 1 ) remains the gold standard for staging COPD, the association between airway remodeling and airflow limitation remains unclear. Objective Endobronchial optical coherence tomography (EB-OCT) was performed to assess the association between disorders of large- and medium-to-small-sized airways and COPD staging. We also evaluated small-airway architecture in heavy-smokers with normal FEV 1 (S NL ) and healthy never-smokers. Methods We recruited 48 COPD patients (stage Ⅰ, n=14; stage Ⅱ, n=15; stage Ⅲ-Ⅳ, n=19), 21 S NL , and 17 healthy never-smokers. Smoking history inquiry, spirometry, chest computed tomography, bronchoscopy and EB-OCT ...
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