1. Articles from Chandra S. Garudadri

    1-13 of 13
    1. Comparison of peripapillary and subfoveal choroidal thickness in normal versus primary open-angle glaucoma (POAG) subjects using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT)

      Comparison of peripapillary and subfoveal choroidal thickness in normal versus primary open-angle glaucoma (POAG) subjects using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT)

      Objective To elucidate the difference between choroidal thickness (CT) in primary open-angle glaucoma (POAG) and normal subjects and to compare the CT measured using spectral domain optical coherence tomography (SD-OCT) and swept source optical coherence tomography (SS-OCT). Methods and analysis This cross-sectional observational study included 25 eyes of 17 POAG subjects (cases) and 31 eyes of 20 normal subjects (controls). All the patients underwent complete ophthalmologic examination, enhanced depth imaging, SD-OCT and SS-OCT. In both controls and cases, the CT was measured in seven predetermined points in macular and peripapillary area and were compared. Results Choroid was significantly thicker on ...

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    2. Factors Affecting the Ability of the Spectral Domain Optical Coherence Tomograph to Detect Photographic Retinal Nerve Fiber Layer Defects

      Factors Affecting the Ability of the Spectral Domain Optical Coherence Tomograph to Detect Photographic Retinal Nerve Fiber Layer Defects

      Purpose To evaluate the ability of normative database classification (color-coded maps) of spectral domain optical coherence tomograph (SDOCT) in detecting wedge shaped retinal nerve fiber layer (RNFL) defects identified on photographs and the factors affecting the ability of SDOCT in detecting these RNFL defects. Methods In a cross-sectional study, 238 eyes (476 RNFL quadrants) of 172 normal subjects and 85 eyes (103 RNFL quadrants with wedge shaped RNFL defects) of 66 glaucoma patients underwent RNFL imaging with SDOCT. Logistic regression models were used to evaluate the factors associated with false positive and false negative RNFL classifications of the color-coded maps ...

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    3. Peripapillary Retinal Nerve Fiber Layer Assessment of Spectral Domain Optical Coherence Tomography and Scanning Laser Polarimetry to Diagnose Preperimetric Glaucoma

      Peripapillary Retinal Nerve Fiber Layer Assessment of Spectral Domain Optical Coherence Tomography and Scanning Laser Polarimetry to Diagnose Preperimetric Glaucoma

      Purpose To compare the abilities of peripapillary retinal nerve fiber layer (RNFL) parameters of spectral domain optical coherence tomograph (SDOCT) and scanning laser polarimeter (GDx enhanced corneal compensation; ECC) in detecting preperimetric glaucoma. Methods In a cross-sectional study, 35 preperimetric glaucoma eyes (32 subjects) and 94 control eyes (74 subjects) underwent digital optic disc photography and RNFL imaging with SDOCT and GDx ECC. Ability of RNFL parameters of SDOCT and GDx ECC to discriminate preperimetric glaucoma eyes from control eyes was compared using area under receiver operating characteristic curves (AUC), sensitivities at fixed specificities and likelihood ratios (LR). Results AUC ...

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    4. Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

      Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

      Purpose: To compare the abilities of standard automated perimetry (SAP) and spectral-domain optical coherence tomography (SDOCT) in diagnosing eyes with glaucomatous optic neuropathy (GON). Methods: In a cross-sectional study, 280 eyes of 175 subjects referred to tertiary eye care center by general ophthalmologists for a glaucoma evaluation underwent retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) imaging with SDOCT. All subjects had at least 2 reliable and repeatable SAP. Two glaucoma experts masked to clinical and SAP results classified the optic nerves into GON and nonglaucomatous groups based on digital optic disc photographs. Ability of SDOCT parameters and ...

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    5. Ganglion Cell-Inner Plexiform Layer Thickness of High Definition Optical Coherence Tomography in Perimetric and Preperimetric Glaucoma

      Ganglion Cell-Inner Plexiform Layer Thickness of High Definition Optical Coherence Tomography in Perimetric and Preperimetric Glaucoma

      Purpose. We determined the diagnostic performance of ganglion cell-inner plexiform layer (GCIPL) parameters of high definition optical coherence tomography (HD-OCT) in perimetric and preperimetric glaucoma, and compared it to optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) parameters. Methods. In a cross-sectional study, 53 eyes of normal subjects and 83 eyes of glaucoma patients (62 perimetric and 21 preperimetric) from the Longitudinal Glaucoma Evaluation Study (LOGES) underwent HD-OCT imaging with Optic Disc and Macular Cube protocols. Diagnostic abilities of GCIPL, ONH, and RNFL parameters were determined using area under receiver operating characteristic curves (AUC) and likelihood ratios ...

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    6. The ISNT rule in glaucoma: revisiting with spectral domain optical coherence tomography

      The ISNT rule in glaucoma: revisiting with spectral domain optical coherence tomography

      Purpose To evaluate the ability of the neuroretinal rim (NRR) rules determined using spectral domain optical coherence tomography (SDOCT) in diagnosing glaucoma and to study the effect of optic disc size and disease severity on the diagnostic ability of these rules. Methods In a cross-sectional study, 125 eyes of 96 glaucoma patients and 96 eyes of 72 control subjects underwent optic nerve head (ONH) imaging with SDOCT. Inferior (I), superior (S), nasal (N) and temporal (T) NRR areas were automatically determined by the sdoct software. Diagnostic abilities of ISNT (I > S > N > T), IT (I > T) and ST (S > T ...

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    7. Reference Standard Test and the Diagnostic Ability of Spectral Domain Optical Coherence Tomography in Glaucoma

      Reference Standard Test and the Diagnostic Ability of Spectral Domain Optical Coherence Tomography in Glaucoma

      Purpose: To evaluate the relationship between the reference standard used to diagnose glaucoma and the diagnostic ability of spectral domain optical coherence tomograph (SDOCT). Methods: In a cross-sectional study, 280 eyes of 175 consecutive subjects, referred to a tertiary eye care center for glaucoma evaluation, underwent optic disc photography, visual field (VF) examination, and SDOCT examination. The cohort was divided into glaucoma and control groups based on 3 reference standards for glaucoma diagnosis: first based on the optic disc classification (179 glaucoma and 101 control eyes), second on VF classification (glaucoma hemifield test outside normal limits and pattern SD with ...

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    8. Effect of Scan Quality on Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Effect of Scan Quality on Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Purpose To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) parameters of spectral-domain optical coherence tomography (SD OCT) in glaucoma. Design Cross-sectional study. Methods Two hundred fifty-two eyes of 183 control subjects (mean deviation [MD]: −1.84 dB) and 207 eyes of 159 glaucoma patients (MD: −7.31 dB) underwent ONH, RNFL, and GCC scanning with SD OCT. Scan quality of SD OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD OCT was evaluated ...

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    9. Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma

      Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma

      Purpose To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomography (SD-OCT) in glaucoma. Design Cross-sectional study. Methods 252 eyes of 183 control subjects (mean MD: -1.84 dB) and 207 eyes of 159 glaucoma patients (mean MD: -7.31 dB) underwent ONH, RNFL and GCC scanning with SD-OCT. Scan quality of SD-OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD-OCT was evaluated by receiver operating characteristic (ROC ...

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    10. Ability of different scanning protocols of spectral domain optical coherence tomography to diagnose preperimetric glaucoma

      Ability of different scanning protocols of spectral domain optical coherence tomography to diagnose preperimetric glaucoma

      Purpose: To evaluate the ability of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomograph (SDOCT) in detecting preperimetric glaucoma. Methods: In a cross-sectional study, 34 preperimetric glaucoma eyes (34 patients) and 72 control eyes (72 subjects) with large physiologic optic disc cupping underwent ONH, RNFL and GCC imaging with SDOCT. Preperimetric glaucoma was diagnosed in the presence of glaucomatous optic neuropathy on masked evaluation of optic disc photographs by two glaucoma experts and normal visual fields. Ability of SDOCT parameters to discriminate preperimetric glaucoma eyes from eyes ...

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    11. Spectral domain optical coherence tomography in children operated for primary congenital glaucoma

      Spectral domain optical coherence tomography in children operated for primary congenital glaucoma

      Aim To evaluate optic nerve head, retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness measurements in children operated for primary congenital glaucoma (PCG) using spectral domain optical coherence tomography (SDOCT). Methods In a case-control study, 45 eyes of 37 children operated for PCG and 72 eyes of 41 normal children underwent optic nerve head, RNFL and GCC imaging with SDOCT. Differences in SDOCT parameters between PCG and control group, correlation between SDOCT parameters and a range of clinical variables, namely preop corneal diameter, intraocular pressure, degree of corneal oedema and age at which surgery was performed in ...

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    12. Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma

      Purpose. To evaluate the influence of a control group on the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) in early glaucoma. Methods. In a diagnostic, case–control study, 119 eyes of 60 normal subjects with no findings suspicious for glaucoma (control cohort 1); 76 eyes of 41 subjects referred by general ophthalmologists as glaucoma suspects based on optic disc morphology, but found by glaucoma experts to be normal but with physiological variations in their optic nerves (control cohort 2); and 65 eyes of 46 early-glaucoma patients (cases) underwent imaging of the optic nerve head (ONH), retinal nerve fiber layer ...

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    13. Predictors of Normal Optic Nerve Head, Retinal Nerve Fiber Layer, and Macular Parameters Measured by Spectral Domain Optical Coherence Tomography

      Predictors of Normal Optic Nerve Head, Retinal Nerve Fiber Layer, and Macular Parameters Measured by Spectral Domain Optical Coherence Tomography

      Purpose. To evaluate the effects of signal strength, age, sex, optic disc size, and axial length on the normal optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular measurements with spectral domain optical coherence tomography (SD-OCT). Methods. In an observational, cross-sectional study, 119 eyes of 60 normal subjects of Indian origin underwent ONH, RNFL, and macular imaging with SD-OCT during the same visit. Linear mixed-modeling methods were used to evaluate the effects of signal strength, age, sex, optic disc area, and axial length on ONH, RNFL, and macular measurements. Results. ONH rim measurements increased and cup measurements decreased ...

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    1-13 of 13
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    Predictors of Normal Optic Nerve Head, Retinal Nerve Fiber Layer, and Macular Parameters Measured by Spectral Domain Optical Coherence Tomography Effect of Spectrum Bias on the Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma Spectral domain optical coherence tomography in children operated for primary congenital glaucoma Ability of different scanning protocols of spectral domain optical coherence tomography to diagnose preperimetric glaucoma Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma Effect of Scan Quality on Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography in Glaucoma Reference Standard Test and the Diagnostic Ability of Spectral Domain Optical Coherence Tomography in Glaucoma The ISNT rule in glaucoma: revisiting with spectral domain optical coherence tomography Ganglion Cell-Inner Plexiform Layer Thickness of High Definition Optical Coherence Tomography in Perimetric and Preperimetric Glaucoma Factors Affecting the Ability of the Spectral Domain Optical Coherence Tomograph to Detect Photographic Retinal Nerve Fiber Layer Defects Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters