1. Articles from Farida Fortune

    1-6 of 6
    1. Scanning Methods And Apparatus

      Scanning Methods And Apparatus

      There is provided a method of identifying a region of interest in sample. The method comprises obtaining one or more optical coherence tomography (OCT) axial scans at one or more locations over the sample surface; for each axial scan, determining an integrated total of OCT intensity over the depth of the scan, and determining an attenuation depth into the sample at which a predetermined fraction of the integrated total is reached; and determining the from the one or more attenuation depths a region of interest in the sample. Generally, the method does not rely the accuracy (or inaccuracy) of any ...

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    2. Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

      Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

      The decision of selecting the most representative site for the biopsy of fluid-filled lesions can be difficult. This may be attributed to the poor delineation of the correct lesional site by clinical observation alone. In this study, optical coherence tomography is used to quantify the contrast between solid- and fluid-filled lesions by measuring the light intensity change at the tissue–fluid interface (intensity drop). This parameter was measured from sequential axial scans (n ≈ 106 per sample) of 3D optical coherence tomography (OCT) datasets from control tissues (n = 14) and fluid-filled lesions (n = 7) and displayed as a 2D-scaled intensity drop ...

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    3. Scanning Methods And Apparatus

      Scanning Methods And Apparatus

      There is provided a method of identifying a region of interest in sample. The method comprises obtaining one or more optical coherence tomography (OCT) axial scans at one or more locations over the sample surface; for each axial scan, determining an integrated total of OCT intensity over the depth of the scan, and determining an attenuation depth into the sample at which a predetermined fraction of the integrated total is reached; and determining from the one or more attenuation depths a region of interest in the sample. Generally, the method does not rely the accuracy (or inaccuracy) of any particular ...

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    4. Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues

      Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues

      Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy site selection. Biopsy samples from patients with fibro-epithelial polyps (n = 13), mild dysplasia (n = 2), and moderate/severe dysplasia (n = 4) were scanned at 5-μm intervals using an OCT microscope ...

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    5. Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues

      Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues

      Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy site selection. Biopsy samples from patients with fibro-epithelial polyps (n = 13), mild dysplasia (n = 2), and moderate/severe dysplasia (n = 4) were scanned at 5-μm intervals using an OCT ...

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    6. Scattering attenuation microscopy of oral epithelial dysplasia

      Scattering attenuation microscopy of oral epithelial dysplasia

      We present a new method for quantitative visualization of premalignant oral epithelium called scattering attenuation microscopy (SAM). Using low-coherence interferometry, SAM projects measurements of epithelial optical attenuation onto an image of the tissue surface as a color map. The measured attenuation is dominated by optical scattering that provides a metric of the severity of oral epithelial dysplasia (OED). Scattering is sensitive to the changes in size and distribution of nuclear material that are characteristic of OED, a condition recognized by the occurrence of basal-cell-like features throughout the epithelial depth. SAM measures the axial intensity change of light backscattered from epithelial ...

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    1-6 of 6
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    Scattering attenuation microscopy of oral epithelial dysplasia Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues Scanning Methods And Apparatus Quantitative optical coherence tomography of fluid-filled oral mucosal lesions Scanning Methods And Apparatus Hybrid registration of retinal fluorescein angiography and optical coherence tomography images of patients with diabetic retinopathy Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy The Role of Optical Coherence Tomography Angiography(OCTA) in Detecting Choroidal Neovascularization in DifferentStages of Best Macular Dystrophy: A Case Series Discrimination of diabetic retinopathy from optical coherence tomography angiography images using machine learning methods Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT) High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice