All Articles from Ursula Schmidt-Erfurth -Optical Coherence Tomography News

Articles from Ursula Schmidt-Erfurth

1-24 of 109 1 2 3 4 5 »
1. Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging
  
  Explore IOVS Journal Jul 11 2020 Ophthalmology
  
  Purpose : To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin–melanolipofuscin (LM), mitochondria, and nuclei. Methods : A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An aligned image stack was generated using serial block-face scanning electron microscopy and was annotated by expert readers (TrakEM, ImageJ). Acquired measures included cell body and nuclear volume ( n = 17); organelle count in apical processes ( n = 17) and cell bodies ( n = 8); distance of cell body organelles along a normalized apical–basal axis ( n = 8); and dimensions ...
  Read Full Article
  
  Comment
  
  Mentions: University of Alabama Michael Pircher Medical University of Vienna
2. Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography
  
  Explore ScienceDirect Jun 30 2020 Ophthalmology
  
  Purpose To compare the performance of automatically quantified optical coherence tomography (OCT) imaging biomarkers and conventional risk factors manually graded on color fundus photographs (CFP) for predicting progression to late age-related macular degeneration (AMD). Design Longitudinal observational study. Participants 280 eyes from 140 participants with bilateral large drusen. Methods All participants underwent OCT and CFP imaging at baseline and were then reviewed at six-monthly intervals to determine progression to late AMD. CFPs were manually graded and OCT scans underwent automated image analyses to quantify risk factors and imaging biomarkers respectively based on drusen and AMD pigmentary abnormalities. Four predictive models ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna University of Melbourne Ursula Schmidt-Erfurth
3. End-to-end deep learning model for predicting treatment requirements in neovascular AMD from longitudinal retinal OCT imaging
  
  Explore IEEE Xplore Jun 26 2020 Ophthalmology
  
  Neovascular age-related macular degeneration (nAMD) is nowadays successfully treated with anti-VEGF substances, but interindividual treatment requirements are vastly heterogeneous and currently poorly plannable resulting in suboptimal treatment frequency. Optical coherence tomography (OCT) with its 3D high-resolution imaging serves as a companion diagnostic to anti-VEGF therapy. This creates a need for building predictive models using automated image analysis of OCT scans acquired during the treatment initiation phase. We propose such a model based on deep learning (DL) architecture, comprised of a densely connected neural network (DenseNet) and a recurrent neural network (RNN), trainable end-to-end. The method starts by sampling several 2D-images ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth
4. Computerized device and method for processing image data
  
  Explore uspto.gov Jun 9 2020 Ophthalmology , Patents
  
  A computerized device for processing image data is proposed. The computerized device comprises a receiving unit which is configured to receive optical coherence tomography data of a of a tissue, in particular of a retina, a providing unit which is configured to provide a convolutional neural network for processing the optical coherence tomography data, and a processing unit which is configured to process the received optical coherence tomography data using the convolutional neural network for identifying at least one certain object in the tissue.
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Georg Langs
5. Subretinal Drusenoid Deposits and Photoreceptor Loss Detecting Global and Local Progression of Geographic Atrophy by SD-OCT Imaging
  
  Explore IOVS Journal Jun 6 2020
  
  Purpose : To investigate the impact of subretinal drusenoid deposits (SDD) and photoreceptor integrity on global and local geographic atrophy (GA) progression. Methods : Eighty-three eyes of 49 patients, aged 50 years and older with GA secondary to age-related macular degeneration (AMD), were prospectively included in this study. Participants underwent spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) imaging at baseline and after 12 months. The junctional zone and presence of SDD were delineated on SD-OCT and FAF images. Linear mixed models were calculated to investigate the association between GA progression and the junctional zone area, baseline GA area, age, global ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Stefan G. Sacu
6. Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography
  
  Explore The JAMA Network May 7 2020 Ophthalmology
  
  Importance The morphologic changes and their pathognomonic distribution in progressing age-related macular degeneration (AMD) are not well understood. Objectives To characterize the pathognomonic distribution and time course of morphologic patterns in AMD and to quantify changes distinctive for progression to macular neovascularization (MNV) and macular atrophy (MA). Design, Setting, and Participants This cohort study included optical coherence tomography (OCT) volumes from study participants with early or intermediate AMD in the fellow eye in the HARBOR (A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular Age-Related Macular Degeneration) trial. Patients underwent imaging monthly for ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Sebastian M. Waldstein
7. Automated Quantification of Photoreceptor alteration in macular disease using Optical Coherence Tomography and Deep Learning
  
  Explore Nature Publishing Group Mar 31 2020 Ophthalmology
  
  Diabetic macular edema (DME) and retina vein occlusion (RVO) are macular diseases in which central photoreceptors are affected due to pathological accumulation of fluid. Optical coherence tomography allows to visually assess and evaluate photoreceptor integrity, whose alteration has been observed as an important biomarker of both diseases. However, the manual quantification of this layered structure is challenging, tedious and time-consuming. In this paper we introduce a deep learning approach for automatically segmenting and characterising photoreceptor alteration. The photoreceptor layer is segmented using an ensemble of four different convolutional neural networks. En-face representations of the layer thickness are produced to characterize ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Sebastian M. Waldstein
8. Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration
  
  Explore ScienceDirect Mar 19 2020 Ophthalmology
  
  Purpose Anti-VEGF treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the retinal armentarium. Optical coherence tomography (OCT) offering three-dimensional imaging of the retina is widely used to guide treatment. Although poor outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible, and quantitative evaluation tools to accurately measure the fluid response i.e. a “VEGF meter” may be a better means of monitoring and treating than the current purely qualitative evaluation used in clinical practice. Design Post-hoc analysis of a phase III, randomized, multicenter study. Participants Study eyes of 1095 treatment-naive subjects receiving pro-re-nata ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Northwestern University Ursula Schmidt-Erfurth
9. SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY, FLUORESCEIN ANGIOGRAPHY, AND INDOCYANINE GREEN ANGIOGRAPHY COMPARISONS REVISITED
  
  Explore LWW Online Dec 10 2019 Ophthalmology
  
  Purpose: To compare area measurements between swept source optical coherence tomography angiography ( SSOCTA ), fluorescein angiography ( FA ), and indocyanine green angiography ( ICGA ) after applying a novel deep-learning-assisted algorithm for accurate image registration. Methods: We applied an algorithm for the segmentation of blood vessels in FA , ICGA , and SSOCTA images of 24 eyes with treatment-naive neovascular age-related macular degeneration. We trained a model based on U-Net and Mask R-CNN for each imaging modality using vessel annotations and junctions to estimate scaling, translation, and rotation. For fine-tuning of the registration, vessels and the elastix framework were used. Area, perimeter, and circularity measurements were ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Semmelweis University
10. An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification
  
  Explore SAGE Journals Nov 18 2019 Ophthalmology
  
  Aims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at the European School for Advanced Studies in Ophthalmology headquarters in Lugano, Switzerland, and elaborated the final document. Results: Seven tomographic qualitative and quantitative features are taken into account and scored ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Universität Rostock Northwestern University
11. U-Net with Spatial Pyramid Pooling for Drusen Segmentation in Optical Coherence Tomography
  
  Explore Home - Springer Oct 15 2019 Ophthalmology
  
  The presence of drusen is the main hallmark of early/intermediate age-related macular degeneration (AMD). Therefore, automated drusen segmentation is an important step in image-guided management of AMD. There are two common approaches to drusen segmentation. In the first, the drusen are segmented directly as a binary classification task. In the second approach, the surrounding retinal layers (outer boundary retinal pigment epithelium (OBRPE) and Bruch’s membrane (BM)) are segmented and the remaining space between these two layers is extracted as drusen. In this work, we extend the standard U-Net architecture with spatial pyramid pooling components to introduce global feature ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth
12. An amplified-target loss approach for photoreceptor layer segmentation in pathological OCT scans
  
  Explore arxiv.org Aug 10 2019 Ophthalmology
  
  Segmenting anatomical structures such as the photoreceptor layer in retinal optical coherence tomography (OCT) scans is challenging in pathological scenarios. Supervised deep learning models trained with standard loss functions are usually able to characterize only the most common disease appeareance from a training set, resulting in suboptimal performance and poor generalization when dealing with unseen lesions. In this paper we propose to overcome this limitation by means of an augmented target loss function framework. We introduce a novel amplified-target loss that explicitly penalizes errors within the central area of the input images, based on the observation that most of the ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth
13. Multiclass segmentation as multitask learning for drusen segmentation in retinal optical coherence tomography
  
  Explore arxiv.org Jun 23 2019 Ophthalmology
  
  Automated drusen segmentation in retinal optical coherence tomography (OCT) scans is relevant for understanding age-related macular degeneration (AMD) risk and progression. This task is usually performed by segmenting the top/bottom anatomical interfaces that define drusen, the outer boundary of the retinal pigment epithelium (OBRPE) and the Bruch's membrane (BM), respectively. In this paper we propose a novel multi-decoder architecture that tackles drusen segmentation as a multitask problem. Instead of training a multiclass model for OBRPE/BM segmentation, we use one decoder per target class and an extra one aiming for the area between the layers. We also introduce ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Leica
14. Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width
  
  Explore Home - Springer Apr 2 2019 Ophthalmology
  
  Purpose The assessment of cup-disc ratio as a surrogate parameter for the neuroretinal rim width (NRW) of the optic nerve is well established, but prone to human error and imprecision. Objective assessment of the NRW is provided by spectral domain optical coherence tomography (SD-OCT). This study is the first to systematically compare NRW measurements acquired with the Carl Zeiss Meditech Cirrus HD-OCT 5000 and the Heidelberg Engineering Spectralis SD-OCT. Methods In this cross-sectional study, 20 eyes of each 20 glaucoma patients and 20 age-matched healthy controls underwent ophthalmic examination, SD-OCT imaging, and computer perimetry. Regression analyses were performed for the ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Engineering Medical University of Vienna Carl Zeiss Meditec
15. Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography
  
  Explore IOVS Journal Dec 19 2018 Ophthalmology
  
  Purpose : To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT). Methods : Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Imaging was repeated every 3 months in each patient to explore the potential structural change of MAs over time including size, shape, intraretinal position, (intra-) luminal reflectivity, and other qualitative morphologic characteristics. Results : We imaged 18 MAs in seven eyes (two left eyes ...
  Read Full Article
  
  Comment
  
  Mentions: Wolfgang Drexler Michael Pircher Medical University of Vienna
16. Fully Automated Segmentation of Hyperreflective Foci in Optical Coherence Tomography Images
  
  Explore arxiv.org May 15 2018 Ophthalmology
  
  The automatic detection of disease related entities in retinal imaging data is relevant for disease- and treatment monitoring. It enables the quantitative assessment of large amounts of data and the corresponding study of disease characteristics. The presence of hyperreflective foci (HRF) is related to disease progression in various retinal diseases. Manual identification of HRF in spectral-domain optical coherence tomography (SD-OCT) scans is error-prone and tedious. We present a fully automated machine learning approach for segmenting HRF in SDOCT scans. Evaluation on annotated OCT images of the retina demonstrates that a residual U-Net allows to segment HRF with high accuracy. As ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Sebastian M. Waldstein
17. Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration
  
  Explore IOVS Journal May 12 2018 Ophthalmology
  
  Purpose : The purpose of this study is to compare the ability of spectral domain optical coherence tomography angiography (SD-OCTA) and indocyanine green angiography (ICGA) to detect and measure lesion area in patients with type 1 and 2 choroidal neovascularization (CNV). Methods : Types 1 and 2 neovascular AMD (nAMD) were included in this prospective and observational case series. ETDRS best-corrected visual acuity (BCVA), ophthalmic examination with funduscopy, OCTA (AngioVue), fluorescein angiography (FA), ICGA, and OCT (Spectralis) were performed. CNV measurements were done manually by two experienced graders using the systems' innate region selection tools. Results : Forty eyes of 39 consecutive patients ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Stefan G. Sacu
18. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
  
  Explore OSA | OSA Publishing Apr 16 2018 Ophthalmology
  
  Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution. The second operation mode enables it to optically zoom into regions of interest with high transverse resolution using adaptive ...
  Read Full Article
  
  Comment
  
  Mentions: Rainer A. Leitgeb Wolfgang Drexler Michael Pircher
19. THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY
  
  Explore LWW Online Feb 1 2018 Ophthalmology
  
  Purpose: To characterize retinal microaneurysms (MAs) in patients with diabetes using adaptive optics optical coherence tomography (AOOCT) and compare details found in AOOCT with those found in commercially available retinal imaging techniques. Methods: Patients with diabetes and MA in the macular area were included in this pilot study. The area of interest, identified in standard fluorescein angiography, was imaged using an AO fundus camera and AOOCT. Microaneurysms were characterized in AOOCT (visibility, reflectivity, feeding/draining vessels, and intraretinal location) and compared with findings in AO fundus camera, OCT angiography, and fluorescein angiography. Results: Fifty-three MAs were imaged in 15 eyes ...
  Read Full Article
  
  Comment
  
  Mentions: Wolfgang Drexler Michael Pircher Medical University of Vienna
20. Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy
  
  Explore Wiley Online Library Jan 16 2018 Ophthalmology
  
  Purpose The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. Methods Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center. These morphologic characteristics were compared with functional variables [best-corrected visual acuity (BCVA), contrast sensitivity (CS), retinal sensitivity/microperimetry, fixation stability], and patients’ subjective handicap from CSC using the National ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Carl Zeiss Meditec Ursula Schmidt-Erfurth
21. Predicting Macular Edema Recurrence from Spatio-Temporal Signatures in Optical Coherence Tomography Images
  
  Explore IEEE Xplore Aug 31 2017
  
  Prediction of treatment responses from available data is key to optimizing personalized treatment. Retinal diseases are treated over long periods and patients’ response patterns differ substantially, ranging from a complete response to a recurrence of the disease and need for re-treatment at different intervals. Linking observable variables in high-dimensional observations to outcome is challenging. In this paper, we present and evaluate two different data-driven machine learning approaches operating in a high-dimensional feature space: sparse logistic regression and random forests-based extra trees (ET). Both identify spatio-temporal signatures based on retinal thickness features measured in longitudinal spectral-domain optical coherence tomography (OCT) imaging ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Georg Langs
22. Predicting Macular Edema Recurrence from Spatio-Temporal Signatures in Optical Coherence Tomography Image
  
  Explore IEEE Xplore May 11 2017 Ophthalmology
  
  Abstract: Prediction of treatment responses from available data is key to optimizing personalized treatment. Retinal diseases are treated over long periods and patients’ response patterns differ substantially, ranging from a complete response to a recurrence of the disease and need for re-treatment at different intervals. Linking observable variables in high-dimensional observations to outcome is challenging. In this paper, we present and evaluate two different data-driven machine learning approaches operating in a high-dimensional feature space: sparse logistic regression and Random Forests based extra trees (ET). Both identify spatio-temporal signatures based on retinal thickness features measured in longitudinal spectral-domain optical coherence tomography ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna Ursula Schmidt-Erfurth Georg Langs
23. COMPARISON OF GANGLION CELL INNER PLEXIFORM LAYER THICKNESS BY CIRRUS AND SPECTRALIS OPTICAL COHERENCE TOMOGRAPHY IN DIABETIC MACULAR EDEMA
  
  Explore LWW Online Apr 5 2017 Ophthalmology
  
  Purpose: Reduced thickness of the ganglion cell inner plexiform layer indicates diabetic neurodegeneration and can be assessed by spectral domain optical coherence tomography. The authors investigated the comparability of ganglion cell inner plexiform layer measurements from two spectral domain optical coherence tomography devices in patients with diabetic macular edema (DME). Methods: Analysis of optical coherence tomography data sets of eyes with and fellow eyes without DME. Macular cube scans of sufficient signal strength on Cirrus (Carl Zeiss Meditec) were compared with correlating scans on Spectralis (Heidelberg Engineering, Germany) being acquired within 1 hour. Results: Eighty-one equivalent data sets for 20 ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Engineering Medical University of Vienna Carl Zeiss Meditec
24. Monitoring retinoschisis and non-acute retinal detachment by optical coherence tomography: morphologic aspects and clinical impact
  
  Explore Wiley Online Library Mar 21 2017 Ophthalmology
  
  Purpose To differentiate retinoschisis (RS) from non-acute retinal detachment (naRD) in clinical routine using optical coherence tomography (OCT), describe unique morphological OCT characteristics and monitor disease progression. Methods This prospective, observational study included 64 eyes of 44 patients with either RS or naRD. Patients were examined clinically and using Heidelberg Spectralis OCT ® , Topcon DRI OCT ® and Cirrus HRA-OCT ® over 2 years with follow-up at 1, 3, 6, 12 and 24 months. Main outcomes were typical morphologic findings of RS and naRD described in OCT. Progression was monitored using Spectralis OCT ® follow-up mapping and an eye-tracking method. Results Forty-seven eyes were ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Engineering Topcon Medical Systems Medical University of Vienna
1-24 of 109 1 2 3 4 5 »