1. Articles from Maria Cristina Savastano

    1-15 of 15
    1. Type 1 Choroidal Neovascularization Evolution by Optical Coherence Tomography Angiography: Long-Term Follow-Up

      Type 1 Choroidal Neovascularization Evolution by Optical Coherence Tomography Angiography: Long-Term Follow-Up

      Purpose . To evaluate structural changes in response to antivascular endothelial growth factor (anti-VEGF) treatment in patients with long-term type 1 choroidal neovascularization (CNV) by optical coherence tomography (OCT) and OCT angiography (OCTA). Method . This is a longitudinal study that involved a total of 51 eyes with type 1 CNV (35 female and 16 male eyes). Structural OCT and OCTA were performed on all the subjects. AngioVue OCTA (XR Avanti, Optovue, Inc., Fremont, CA) was used to obtain qualitative and quantitative information. All eyes were treated with an anti-VEGF ProReNata (PRN) approach and were followed for a mean of 38.9 ...

      Read Full Article
    2. Fluorescein angiography versus optical coherence tomography angiography: FA vs OCTA Italian Study

      Fluorescein angiography versus optical coherence tomography angiography: FA vs OCTA Italian Study

      Purpose: To assess the current role of fluorescein angiography after the introduction of optical coherence tomography angiography in real-life clinical practice. Methods: This was a multicentric retrospective observational study to evaluate the number of fluorescein angiography and optical coherence tomography angiography procedures performed by different devices from January 2013 to December 2018. The centers involved were Centro Italiano Macula (Rome), and ophthalmology departments of University “G. D’Annunzio” Chieti–Pescara (Chieti) and “Azienda Ospedaliero Universitaria Careggi” (Florence). Results: Out of 19,898 total fluorescein angiography procedures performed in the observation period, 3444 (17.3%) were in 2013, 3972 (19.9 ...

      Read Full Article
    3. Morpho-Functional Evaluation of Full-Thickness Macular Holes by the Integration of Optical Coherence Tomography Angiography and Microperimetry

      Morpho-Functional Evaluation of Full-Thickness Macular Holes by the Integration of Optical Coherence Tomography Angiography and Microperimetry

      (1) Objective: To use optical coherence tomography angiography (OCTA) and microperimetry (MP) to evaluate the correlation between retinal structure and function in patients with idiopathic, full-thickness macular holes (FTMHs) (2) Methods: This prospective, observational study included 11 eyes of 10 patients with FTMHs evaluated before surgery using OCTA and MP. MP sensitivity maps were superimposed and registered on slabs corresponding to superficial capillary plexus (SCP) and deep capillary plexus (DCP) on OCTA, and on the outer plexiform layer (OPL) and the Henle fiber layer (HFL) complex in en face OCT. On these maps, mean retinal sensitivity was calculated at 2 ...

      Read Full Article
    4. Choroidal juxtapapillary neovascularization regression in multiple evanescent white dot syndrome by optical coherence tomography angiography: a case report

      Choroidal juxtapapillary neovascularization regression in multiple evanescent white dot syndrome by optical coherence tomography angiography: a case report

      Background Multiple evanescent white dot syndrome most often resolves spontaneously without complications; however, choroidal neovascularization can sometimes occur. Case presentation Here, we describe a case of a 22-year-old white Caucasian man with blurred vision in his left eye who exhibited juxtapapillary choroidal neovascularization on optical coherence tomography angiography. Although multiple evanescent white dot syndrome is often self-limiting, to reduce the possibility of an inflammatory reaction, we preferred to administer prednisolone orally. After 3 months, significant regression of juxtapapillary neovascularization was observed by B-scan and optical coherence tomography angiography. Symptoms resolved in 3 months. A steady situation was observed at 4 ...

      Read Full Article
    5. Swept source optical coherence tomography and optical coherence tomography angiography in pediatric enhanced S-cone syndrome: a case report

      Swept source optical coherence tomography and optical coherence tomography angiography in pediatric enhanced S-cone syndrome: a case report

      Background Enhanced S-cone syndrome is an autosomal recessive retinal dystrophy related to a defect in a nuclear receptor gene ( NR2E3 ) that leads to alteration in cells development from rod to S-cone. This retinal dystrophy may be associated with retinal schisis. The aim of this report is to describe structural optical coherence tomography and optical coherence tomography angiography features in a case of enhanced S-cone syndrome associated with macular schisis. Case presentation A Caucasian 13-year-old girl underwent measurement of best corrected visual acuity, ophthalmoscopic evaluation, and fundus autofluorescence examination. Photopic and scotopic electroretinography were carried out as well. Enhanced S-cone syndrome ...

      Read Full Article
    6. Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      Vascular Features of Full-Thickness Macular Hole by OCT Angiography

      BACKGROUND AND OBJECTIVE: To compare the features of cystoid cavities associated with full-thickness macular hole (FTMH) imaged with optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Prospective, observational, cross-sectional study. Clinical practice and observation. Thirteen patients (13 eyes) with FTMH were evaluated before vitrectomy. All eyes underwent OCTA or en face OCT imaging. RESULTS: There was a statistically significant positive correlation between groups for the total cavity area in both inner nuclear layer ( P < .001; r 2 = 0.82) and outer plexiform and Henle fiber layer complex ( P < .001; r 2 = 0.84). CONCLUSIONS: OCTA and ...

      Read Full Article
    7. Capillary Network Anomalies In Branch Retinal Vein Occlusion On Optical Coherence Tomography Angiography

      Capillary Network Anomalies In Branch Retinal Vein Occlusion On Optical Coherence Tomography Angiography

      Purpose: To analyze the foveal microvasculature features in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography angiography based on split spectrum amplitude decorrelation angiography technology. Methods: A total of 10 BRVO eyes (mean age 64.2 ± 8.02 range between 52 years and 76 years) were evaluated by optical coherence tomography angiography (XR-Avanti; Optovue). The macular angiography scan protocol covered a 3 mm × 3 mm area. The focus of angiography analysis were two retinal layers: superficial vascular network and deep vascular network. The following vascular morphological congestion parameters were assessed in the vein occlusion area in both ...

      Read Full Article
    8. En Face Optical Coherence Tomography for Visualization of the Choroid

      En Face Optical Coherence Tomography for Visualization of the Choroid

      BACKGROUND AND OBJECTIVE: To assess posterior pole choroid patterns in healthy eyes using en face optical coherence tomography (OCT). PATIENTS AND METHODS: This observational study included 154 healthy eyes of 77 patients who underwent en face OCT. The mean age of the patients was 31.2 years (standard deviation: 13 years); 40 patients were women, and 37 patients were men. En face imaging of the choroidal vasculature was assessed using an OCT Optovue RTVue (Optovue, Fremont, CA). To generate an appropriate choroid image, the best detectable vessels in Haller’s layer below the retinal pigment epithelium surface parallel plane were ...

      Read Full Article
    9. IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To evaluate retinal vessel morphology using split-spectrum amplitude-decorrelation angiography with optical coherence tomography in healthy eyes. Methods: Fifty-two eyes of 26 healthy volunteers (age range from 35 to 48 years; mean age 41.94 years; SD: +/-4.13) were evaluated by optical coherence tomography angiography in the macular region. The protocol acquisition consisted of a 216 x 216 A-scan that was repeated 5 times in the same position, in 3 x 3 mm centered into the fovea. Results: All 52 eyes showed 2 separate vascular networks in the inner retina: the superficial network, located in the nerve fiber layer ...

      Read Full Article
    10. En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells

      En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells

      Purpose To characterize perifoveal intraretinal cavities observed around full-thickness macular holes (MH) using en face optical coherence tomography and to establish correlations with histology of human and primate maculae. Design Retrospective non-consecutive observational case series. Methods Macular en face scans of eight patients with MH were analyzed to quantify the areas of hyporeflective spaces, and compared with macular flat-mounts and sections from one normal human donor eye and two normal primate eyes (Macaca fascicularis). Immunohistochemistry was used to study the distribution of glutamine synthetase, expressed by Müller cells, and zonula occludens-1, a tight-junction protein. Results The mean area of ...

      Read Full Article
    11. Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis.

      Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis.

      Purpose:To evaluate layer-by-layer retinal thickness in spectral-domain optical coherence tomography (SD-OCT), determined by automated segmentation analysis (ASA) software in healthy and early age-related maculopathy (ARM) eyes. Methods:Fifty-seven eyes, specifically, 19 healthy eyes under 60 years old, 19 healthy eyes over 60, and 19 ARM eyes, were recruited into this cross-sectional study. The mean ages were 36.78 (SD: ± 13.82), 69.89 (SD: ± 6.14) and 66.10 (SD: ± 8.67) years, respectively, in the three study groups. SD-OCT scans were transferred into a dedicated software program that performed automated segmentation of different retinal layers. Results:Automated layer ...

      Read Full Article
    12. Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

      Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography

      Although the changes in the anatomy of the visual cortex and lateral geniculate nucleus as the result of amblyopia have been well documented, retinal involvement is still controversial. Time-domain optical coherence tomography with an axial resolution of 10 μm has been used to evaluate retinal and peripapillary tissues in amblyopic eyes with contradictory results. Spectral domain optical coherence tomography has a greater resolution (5–10 μm) and can determine retinal layers more precisely. Our purpose was assess by means of spectral domain optical coherence tomography whether the retinal nerve fiber layer thickness, macular thickness, and foveal volume of the amblyopic ...

      Read Full Article
    13. A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry

      A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry

      Purpose: To determine whether retinal nerve fiber layer thickness (RNFLT), macular thickness, foveal volume, macular sensitivity, and fixation in patients with amblyopia differ between the amblyopic eye and the fellow eye.Methods: Optical coherence tomography (OCT) and microperimetry (MP-1) were used to evaluate patients with unilateral amblyopia. Patients were divided into 2 groups, those with strabismic amblyopia and those with refractive amblyopia. OCT maps were used to calculate foveal volume, macular thickness, and RNFLT; MP-1 was used to determine macular sensitivity and fixation.Results: A total of 30 patients were included (13 males; mean age 19.7 years [range, 10-38 ...

      Read Full Article
    14. Morphologic Differences, According To Etiology, in Pigment Epithelial Detachments By Means of En Face Optical Coherence Tomography

      Morphologic Differences, According To Etiology, in Pigment Epithelial Detachments By Means of En Face Optical Coherence Tomography

      Purpose: To assess morphologic differences in pigment epithelial detachment (PED) with en face optical coherence tomography in central serous chorioretinopathy (CSC) and age-related macular degeneration (AMD). Methods: We recruited 30 eyes of 22 patients with PED. Nine eyes had a clinical diagnosis of CSC and 21 had AMD. All patients were assessed with en face optical coherence tomography. Morphologic PED aspects were estimated on C-scans and classified according to shape, inner silhouette, content, wall aspects, wall thickness, and size. Results: Pigment epithelial detachment shape was predominantly circular (88.8%) in CSC and irregular or with multilobular features in AMD (76 ...

      Read Full Article
    1-15 of 15
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (14 articles) Maria Cristina Savastano
    2. (8 articles) Marco Rispoli
    3. (8 articles) Bruno Lumbroso
    4. (3 articles) Optovue
    5. (1 articles) University of Florence
    6. (1 articles) National Institutes of Health
    7. (1 articles) University of Lausanne
    8. (1 articles) Institute of Applied Physics
    9. (1 articles) Medical University of Vienna
    10. (1 articles) Kyungpook National University
    11. (1 articles) Singapore Eye Research Institute
    12. (1 articles) University of Western Australia
    13. (1 articles) Stefan G. Sacu
    14. (1 articles) Brendan F. Kennedy
    15. (1 articles) Yongyang Huang
    16. (1 articles) Jeehyun Kim
    17. (1 articles) Ursula Schmidt-Erfurth
  3. Popular Articles

  4. Picture Gallery

    Morphologic Differences, According To Etiology, in Pigment Epithelial Detachments By Means of En Face Optical Coherence Tomography A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis. En face optical coherence tomography of foveal microstructure in full-thickness macular hole: a model to study perifoveal Müller cells IN VIVO CHARACTERIZATION OF RETINAL VASCULARIZATION MORPHOLOGY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY En Face Optical Coherence Tomography for Visualization of the Choroid Capillary Network Anomalies In Branch Retinal Vein Occlusion On Optical Coherence Tomography Angiography Detecting papillary neovascularization in proliferative diabetic retinopathy using optical coherence tomography angiography Vascular Features of Full-Thickness Macular Hole by OCT Angiography Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)