1. Articles from Nai-Chia Cheng

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    1. Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography

      Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography


      The aim of cancer therapies is mainly to stop cell proliferation or induce cell death. Cell death regulation is important for normal development and homeostasis. Cancer cells escape from death signals and continue their abnormal proliferation. Therefore, the ability to induce death in cancer cells has been a crucial biomarker for the efficacy of chemotherapeutic agents. However, individual cancer cells, even from the same population, vary greatly in their response to cell death stimuli. Measuring the response at the single-cell levels provide further pharmacokinetic and pharmacodynamics information, which aids drug development and regimen design. Developing a microscopic technology with non-invasive ...

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    2. Cell death detection by quantitative three-dimensional single-cell tomography

      Cell death detection by quantitative three-dimensional single-cell tomography

      Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death ...

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    3. Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel

      Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel
      e microstructural and microspectral characteristics of a vertically aligned liquid crystal display (VA-LCD) panel were obtained noninvasively for the first time. With 1 μm axial and 2 μm transversal resolutions, the cell gap profile beneath the patterned thin-film transistor of the VA-LCD panel can clearly be resolved. The thicknesses of the multiple thin-film layers and the embedded defects can also be unveiled. As far as spectral response is concerned, the light transmittance at the layer boundaries can be estimated from the measured reflectance, which is crucial information for the design of a highly transmissive panel. The color shift of the ...
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    1-3 of 3
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    1. (3 articles) National Taiwan University
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    Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel Cell death detection by quantitative three-dimensional single-cell tomography Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography Intraoperative Optical Coherence Tomography in Idiopathic Macular Epiretinal Membrane Surgery Quantitative approaches in multimodal fundus imaging: State of the art and future perspectives Non-cystic macular thickening on optical coherence tomography as an alternative to fluorescein angiography for predicting retinal vascular leakage in early stages of uveitis Self-supervised patient-specific features learning for OCT image classification Accurate In Vivo Bowman's Thickness Measurement Using Mirau Ultrahigh Axial Resolution Line Field Optical Coherence Tomography Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders Longitudinal Evaluation of Changes in Retinal Architecture Using Optical Coherence Tomography in Achromatopsia Large Amplitude Iris Fluttering Detected by Consecutive Anterior Segment Optical Coherence Tomography Images in Eyes with Intrascleral Fixation of an Intraocular Lens Magnetic Field-Modulated Plasmonic Scattering of Hybrid Nanorods for FFT-Weighted OCT Imaging in NIR-II