1. Articles from Guoyong Wu

    1-11 of 11
    1. Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra

      Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra

      The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide ( TiO 2 ) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO 2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment ...

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    2. Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT

      Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT

      In this work, the potential use of nanoparticles as contrast agents by using spectral domain optical coherence tomography (SD-OCT) in liver tissue was demonstrated. Gold nanoparticles (average size of 25 and 70 nm), were studied in human normal and cancerous liver tissues in vitro , respectively. Each sample was monitored with SD-OCT functional imaging for 240 min. Continuous OCT monitoring showed that, after application of gold nanoparticles, the OCT signal intensities of normal liver and cancerous liver tissue both increase with time, and the larger nanoparticles tend to produce a greater signal enhancement in the same type of tissue. The results ...

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    3. Monitoring of permeability of different analytes in human normal and cancerous bladder tissues invitro using optical coherence tomography

      Monitoring of permeability of different analytes in human normal and cancerous bladder tissues invitro using optical coherence tomography

      We report our preliminary results on quantification of glucose and dimethyl sulfoxide (DMSO) diffusion in normal and cancerous human bladder tissues in vitro by using a spectral domain optical coherence tomography (SD-OCT). The permeability coefficients (PCs) of a 30% aqueous solution of glucose are found to be (7.92 ± 0.81) × 10 -6 cm s -1 and (1.19 ± 0.13) × 10 -5 cm s -1 in normal and cancerous bladder tissues, respectively. The PCs of 50% DMSO are calculated to be (8.99 ± 0.93) × 10 -6 cm s -1 and (1.43 ± 0.17) × 10 -5 cm s ...

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    4. In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography

      In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography

      No published reports have demonstrated the capability of the optical coherence tomography technique for quantifying the optical coherence tomography signal slope, 1/e light penetration depth, and attenuation coefficient of hyperglycemic blood by an in vitro assessment. The purpose of this study was to investigate the effects of hyperglycemia on optical properties during in vitro blood coagulation by optical coherence tomography. Normal whole blood acted as the control group. After 1-h coagulation, the average optical coherence tomography signal slope decreased approximately 23.3 and 16.7 %, and the 1/e light penetration depths increased approximately 21.5 and 19.2 ...

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    5. Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      The objective of this study was to evaluate the effects of blood glucose concentration (BGC) on in vivo human skin optical properties after oral intake of different sugars. In vivo optical properties of human skin were measured with a spectral domain optical coherence tomography (SD-OCT). Experimental results show that increase of BGC causes a decrease in the skin attenuation coefficient. And the maximum decrements in mean attenuation coefficient of skin tissue after drinking glucose, sucrose and fructose solution are 47.0%, 36.4% and 16.5% compared with that after drinking water, respectively (p < 0.05). The results also show ...

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    6. Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT

      Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT

      The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect.

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    7. Noninvasive blood glucose monitoring during oral intake of different sugars with optical coherence tomography in human subjects

      Noninvasive blood glucose monitoring during oral intake of different sugars with optical coherence tomography in human subjects

      The potential of OCT applied to noninvasive blood glucose monitoring has attracted significant efforts. In this work we investigated the feasibility of OCT in monitoring blood glucose during oral intake of different sugars in humans. Five groups of experiments were performed, in which different sugars were used. The OCT signal slope (OCTSS) changed with variation of blood glucose concentration (BGC). A good correlation between OCTSS and BGC was observed in these experiments. The averaged correlation coefficients R between OCTSS and BGC are 0.900, 0.836, 0.895 and 0.884, corresponding to oral administration of glucose, fructose, sucrose and ...

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    8. Assessment of the effects of ultrasound-mediated glucose on permeability of normal, benign, and cancerous human lung tissues with the Fourier-domain optical coherence tomography

      Assessment of the effects of ultrasound-mediated glucose on permeability of normal, benign, and cancerous human lung tissues with the Fourier-domain optical coherence tomography

      The objective of this study was to evaluate the effects of ultrasound-mediated analyte diffusion on permeability of normal, benign, and cancerous human lung tissue in vitro and to find more effective sonophoretic (SP) delivery in combination with the optical clearing agents (OCAs) method to distinguish normal and diseased lung tissues. The permeability coefficients of SP in combination with OCAs diffusion in lung tissue were measured with Fourier-domain optical coherence tomography (FD-OCT). 30% glucose and SP with a frequency of 1 MHz and an intensity of 0.80     W / cm 2 over a 3 cm probe was simultaneously applied for 15 ...

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    9. Synergistic effect of hyperosmotic agents and sonophoresis on breast tissue optical properties and permeability studied with spectral domain optical coherence tomography

      Synergistic effect of hyperosmotic agents and sonophoresis on breast tissue optical properties and permeability studied with spectral domain optical coherence tomography

      Hyperosmotic agents have shown great potential in tissue optical clearing. However, the low efficiency of the permeation in biological tissues seriously restricts its application in reality. The synergy of sonophoresis as a penetration enhancer and hyperosmotic agents, 20% glucose (G) and 20% mannitol (M), in optical clearing has been investigated by analyzing the variation of the attenuation coefficients and the permeability coefficients. In the sonophoresis experiments, ultrasound (US) was applied for 10 min before applying hyperosmotic agents. Along with the administration of hyperosmotic agents, the samples were monitored with optical coherence tomography (OCT) functional imaging for the next 2 h ...

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    10. Quantification of Glucose Diffusion in Human Lung Tissues by Using Fourier Domain Optical Coherence Tomography

      Quantification of Glucose Diffusion in Human Lung Tissues by Using Fourier Domain Optical Coherence Tomography

      In this study, we report permeability coefficients of 30% glucose diffusion by the optical coherence tomography signal slope (OCTSS) method in four kind of human lung tissue in vitro: normal lung tissue, benign granulomatosis lung tissue, squamous cell carcinoma, and adenocarcinoma tumor. To quantify the permeability coefficient of the agent, the monitored region was the 80 um thickness at a tissue depth of approximately 230 um from the surface. The permeability coefficients of 30% glucose from 10 independent experiments were averaged and found to be (1.35 ± 0.13)×10 −5 cm/s from the normal lung tissue, (1.78 ...

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    11. In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      The objective of the present work is to quantify and compare the optical clearing efficacy of glucose, propylene glycol, glycerol solutions through the human skin tissue in vivo by calculating permeability coefficient of three solutions. Currently, the permeability coefficient of agent in tissues was extracted from OCT amplitude data mainly through the OCT signal slope (OCTSS) and the OCT amplitude (OCTA) methods. In this study, we report the OCT attenuation coefficient (OCTAC) method which is relatively novel and rarely reported methodology to measure the permeability coefficient during the optical skin clearing procedure. The permeability coefficients for 40% propylene glycol, glucose ...

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    1-11 of 11
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    In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography Quantification of Glucose Diffusion in Human Lung Tissues by Using Fourier Domain Optical Coherence Tomography Synergistic effect of hyperosmotic agents and sonophoresis on breast tissue optical properties and permeability studied with spectral domain optical coherence tomography Assessment of the effects of ultrasound-mediated glucose on permeability of normal, benign, and cancerous human lung tissues with the Fourier-domain optical coherence tomography Noninvasive blood glucose monitoring during oral intake of different sugars with optical coherence tomography in human subjects Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography Monitoring of permeability of different analytes in human normal and cancerous bladder tissues invitro using optical coherence tomography Influence of nanoparticles accumulation on optical properties of human normal and cancerous liver tissue in vitro estimated by OCT Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis Clinical presentation does not affect acute mechanical performance of the Novolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography