1. Articles from Timothy Q. Duong

    1-6 of 6
    1. Feature Of The Week 5/26/2013: University of Texas at Austin Investigates Dual-Wavelength Photothermal OCT for Imaging Microvasculature Blood Oxygen Saturation

      Feature Of The Week 5/26/2013: University of Texas at Austin Investigates Dual-Wavelength Photothermal OCT for Imaging Microvasculature Blood Oxygen Saturation

      A swept-source dual-wavelength photothermal optical coherence tomography (DWP-OCT) is demonstrated for imaging and measurement of microvasculature oxygen saturation (SO2). DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitations in two different wavelengths (770 and 800 nm). Two phantom microvessels with different inner-diameter size (50 and 300 μm) were constructed, porcine blood with various SO2 levels were prepared for the experiment. Phantom microvessels were imaged and blood SO2 levels measured using DWP-OCT are compared with values provided by a commercial oximeter. Propagation error analysis suggests DWP-OCT is feasible for measurement of blood ...

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    2. Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

      Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

      A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation ( SO 2 ) levels in phantom blood vessels with a range of blood flow speeds (0 to 17     mm / s ). A 50- μ m-diameter blood vessel phantom is imaged, and SO 2 levels are measured using DWP-OCT and compared with ...

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    3. Feature Of The Week 1/22/12: In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT.

      Feature Of The Week 1/22/12: In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT.
      All mammalian tissues need oxygen for survival. The human body has a delicately organized vascular network that supplies our tissue with oxygen and other nutrients as well as removing waist products. Not surprisingly, aberrations in vascular oxygen supply are implicated in at least 70 diseases and that number continues to grow. The oxygen distribution from vascular hemoglobin to the parenchymal cells begins with oxygen diffusion first from arterioles with diameters less than 50 µm, and second from capillaries, with deoxygenated blood draining back to venules where the blood is redirected to the lungs for re-oxygenation. The earliest abnormalities in oxygen ...
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    4. In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT

      In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT
      Microvasculature hemoglobin oxygen saturation (SaO2) is important in the progression of various pathologies. Non-invasive depth-resolved measurement of SaO2 levels in tissue microvasculature has the potential to provide early biomarkers and a better understanding of the pathophysiological processes allowing improved diagnostics and prediction of disease progression. We report proof-of-concept in vivo depth-resolved measurement of SaO2 levels in selected 30 µm diameter arterioles in the murine brain using Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) with 800 nm and 770 nm photothermal excitation wavelengths. Depth location of back-reflected light from a target arteriole was confirmed using Doppler and speckle contrast OCT images ...
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    5. Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

      Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography
      Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO2 levels in a blood vessel phantom. DWP OCT SaO2 is linearly correlated with blood-gas SaO2 measurements. We demonstrate 6.3% precision in SaO2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO2 levels measured with DWP-OCT are identified and characterized.
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    1-6 of 6
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    Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT Feature Of The Week 1/22/12: In vivo depth-resolved oxygen saturation by dual-wavelength photothermal (DWP) OCT. Methods And Apparatus Related To Photothermal Optical Coherence Tomography (Oct) Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation Feature Of The Week 5/26/2013: University of Texas at Austin Investigates Dual-Wavelength Photothermal OCT for Imaging Microvasculature Blood Oxygen Saturation Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography Health collaborations forged at CIIE begin to bear fruit Method for determining the topography of the cornea of an eye Optical measurement system using multicore optical fiber Fiber optic rotary joints and methods of using and manufacturing same High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation