1. Articles from Ron Waksman

    1-14 of 14
    1. Deoxyribonucleic Acid Repair Activity Is Associated with Healed Coronary Plaque Rupture by Optical Coherence Tomography

      Deoxyribonucleic Acid Repair Activity Is Associated with Healed Coronary Plaque Rupture by Optical Coherence Tomography

      Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. The population included patients with stable angina pectoris (SA) and non-ST-elevation myocardial infarction (NSTEMI). It was found that the prevalence of HCPR was greater in subjects with higher DNA ligase activity (correlation ...

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    2. First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S

      First Report of Edge Vascular Response at 12 Months of Magmaris, A Second-Generation Drug-Eluting Resorbable Magnesium Scaffold, Assessed by Grayscale Intravascular Ultrasound, Virtual Histology, and Optical Coherence Tomography. A Biosolve-II Trial Sub-S

      Introduction and objective The edge vascular response (EVR) remains unknown in second generation drug-eluting Resorbable Magnesium Scaffold (RMS), such as Magmaris. The aim of the study was to evaluate tissue modifications in the RMS edges over time, assessed by different invasive imaging modalities. Methods The patients treated with the device were assessed by optical coherence tomography (OCT), grayscale intravascular ultrasound (IVUS), and virtual histology IVUS at baseline and 12 months. The EVR study performed a segment- and frame-level analysis of the 5 mm segments proximal and distal of the actual RMS. Results The segment-level grayscale IVUS (n = 10), virtual histology ...

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    3. Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Techniques to Optimize the Use of Optical Coherence Tomography: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database

      Background/Purpose Optical coherence tomography (OCT) is a high-resolution intravascular imaging modality used to assess coronary arteries and as an adjunctive tool for optimization of percutaneous coronary interventions. Overall, the rate of complications and adverse events related to intravascular imaging is low. Limited data exist on the most commonly reported complications and modes of failure related to the use of OCT. Therefore, we analyzed the post-marketing surveillance data from the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to assess the reported complications and failure modes for OCT and reviewed techniques to optimize device use. Methods ...

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    4. Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography

      Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography

      Background Double kissing (DK) crush stenting has been reported as a superior bifurcation stenting strategy compared to culotte stenting. However, the mechanism associated with the reduction of clinical events by DK crush stenting remains unclear. We therefore investigated the thrombogenicity of DK crush stenting and culotte stenting with both bare-metal stents (BMS) and drug-eluting stents (DES) and the feasibility of a novel porcine arteriovenous shunt model. Methods High-resolution intracoronary imaging with optical coherence tomography (OCT) evaluated the bifurcation stenting models for thrombogenicity. Results All porcine models retained continuous circulation without blood leakage. Thrombus was macroscopically demonstrated around the bifurcation in ...

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    5. Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)

      Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial)

      Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is used for treating coronary lesions. However, the natural history of the jailed side-branch (SB) after DREAMS 2G implantation remains to be elucidated. The aim of this study is to investigate the effect of scaffold struts on jailed SBs as assessed by 3-dimensional (3D) optical coherence tomography (OCT) after implantation of DREAMS 2G. We enrolled the patients who received a DREAMS 2G implantation and where OCT was performed at post-procedure and 12-month follow-up in the BIOSOLVE-II trial. The area of the ostium of jailed SBs and number of compartments divided by scaffold struts ...

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    6. Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis

      Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis

      Aims Second-generation drug-eluting absorbable metal scaffold (DREAMS 2G) is an alternative novel device for treating coronary lesions. However, the relationship between in-scaffold dimensions after implantation of DREAMS 2G and vessel healing and luminal results at follow-up is unknown. The aim of this study is, therefore, to investigate whether the expansion index after implantation of DREAMS 2G as assessed by optical coherence tomography (OCT) impacts late luminal status and healing of the vessel wall. Methods and results This study comprises of a total 65 out of 123 patients who were enrolled in the BIOSOLVE-II trial. We assessed both qualitative and quantitative ...

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    7. Intracoronary imaging: see more, better or worse?

      Intracoronary imaging: see more, better or worse?

      The field of intracoronary imaging emerged to overcome the drawbacks of coronary angiography. The visual evaluation of lesion severity of coronary stenosis by angiography remains insufficient for accurate diagnosis of the vessel indices and its estimate of functional significance. 1 Intracoronary imaging was introduced to optimize the outcome of percutaneous coronary intervention (PCI), aiming to reduce short- and long-term cardiovascular events. Intracoronary imaging systems, such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT), offer an inside look into the artery, which enables precision in evaluation of the vessel dimension, plaque composition, and degree of narrowing, and allows optimization of ...

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    8. Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      A 75-year-old woman with stable angina pectoris underwent percutaneous coronary intervention of the left anterior descending coronary artery, whereby a 3.25/16-mm paclitaxel-eluting absorbable metal scaffold (DREAMS, Biotronik, Bülach, Switzerland) was successfully implanted. Post-procedural angiography showed excellent results without pinching of the side branch ostium. The patient experienced no procedure-related complications, and was discharged 48 h after the procedure on dual antiplatelet therapy. Optical coherence tomography (OCT) (LightLab Imaging, Westford, Massachusetts) was performed post-procedure and at 12 months follow-up. Post-procedurally, the scaffold was well expanded with good apposition of struts to the vessel wall, and a side branch ...

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    9. Intra-Stent Tissue Evaluation within Bare Metal and Drug-Eluting Stents > 3 Years since Implantation in Patients with Mild to Moderate Neointimal Proliferation Using Optical Coherence Tomography and Virtual Histology Intravascular Ultrasound

      Intra-Stent Tissue Evaluation within Bare Metal and Drug-Eluting Stents > 3 Years since Implantation in Patients with Mild to Moderate Neointimal Proliferation Using Optical Coherence Tomography and Virtual Histology Intravascular Ultrasound

      Objective: We aimed to compare neointimal tissue characteristics between bare-metal stents (BMS) and drug-eluting stents (DES) at long-term follow-up using optical coherence tomography (OCT) and virtual histology intravascular ultrasound (VH-IVUS). Background: Neoatherosclerosis in neointima has been reported in BMS and in DES. Methods: Thirty patients with 36 stented lesions [BMS (n = 17) or DES (n = 19)] > 3 years after implantation were prospectively enrolled. OCT and VH-IVUS were performed and analyzed independently. Stents with ≥ 70% diameter stenosis were excluded. Results: The median duration from implantation was 126.0 months in the BMS group and 60.0 months in the DES group ...

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    10. Serial Observation of Drug-Eluting Absorbable Metal Scaffold Multi-Imaging Modality Assessment

      Serial Observation of Drug-Eluting Absorbable Metal Scaffold Multi-Imaging Modality Assessment

      Background— The drug-eluting absorbable metal scaffold has demonstrated feasibility, safety, and promising clinical and angiographic outcomes at 12 months in human coronary arteries. This study aimed to evaluate the degradation rate and long-term vascular responses to drug-eluting absorbable metal scaffold. Methods and Results— BIOSOLVE-I was a multicenter, single-arm, first-in-man trial assessing the safety and performance of drug-eluting absorbable metal scaffold in 46 patients with coronary artery disease. Patients who underwent serial invasive imaging, such as quantitative coronary angiography, intravascular ultrasound, and optical coherence tomography, at 6 and 12 months were included in this study. From postimplantation to follow-up, arterial curvature ...

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    11. Intravascular Ultrasound Versus Optical Coherence Tomography Guidance

      Intravascular Ultrasound Versus Optical Coherence Tomography Guidance

      IVUS Versus Angiography Guidance for DES PlacementFirst Author/Study (Ref. #), Year (Study)nStudy PopulationStudy DesignIVUS Criteria for Optimal ExpansionCriteria FulfilledMain Outcome MeasuresResultsRoy et al. (2), 20081,768De novo native coronary lesions, restenotic and SVG lesionsSingle-center registryDiscretion of the treating operator—Definite stent thrombosis and MACE at 12 monthsIVUS better (stent thrombosis and TLR)Classen et al. (3), 2011 (MATRIX)1,504 (SES)De novo native coronary and restenotic lesionsMulticenter registryDiscretion of the treating operator—30-day, 1-yr, and 2-yr rates of death/MI, MACE, and stent thrombosisIVUS betterPark et al. (4), 2009682Left main lesionsMulticenter registryDiscretion of the treating operator3-yr mortalityIVUS betterChieffo ...

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    12. OCT in Coronary Bifurcations (Book Chapter)

      OCT in Coronary Bifurcations (Book Chapter)

      The geometric and anatomical complexity of bifurcations makes its systematic scientific approach very challenging. Optical coherence tomography (OCT) is able to depict accurately the plaque distribution around the bifurcation, to provide valuable information to tailor the procedure in each specific case, and to assess the result after stenting. Some guidelines are proposed for the systematic study of bifurcations with OCT, assessing the apposition, tissue coverage, the presence of overlap or multi-layer segments, the presence of non-apposed side-branch struts, the scaffolding of the carina and the shoulder, and the access to the side branch.

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    13. Optical Coherence Tomography: A New Imaging Modality for Plaque Characterization and Stent Implantation

      Optical Coherence Tomography: A New Imaging Modality for Plaque Characterization and Stent Implantation

      Optical coherence tomography (OCT) is a novel, catheter-based, invasive imaging system based on near-infrared light with high image resolution (15–20 μm). The system allows for unparalleled imaging of the coronary artery lumen, plaque characterization, assessment of coronary stent strut apposition, neointimal coverage, vascular proliferative response, complications such as focal dissection or thrombus formation, and insight into the time course of stent endothelization. This review will describe the currently available developments in OCT technology and its application in both the clinical and research arenas.

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    14. Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries

      Abstract: Background: Absorbable metallic stents (AMS) composed of magnesium alloy were designed to complete degradation within 90–120 days. Among the potential advantages of these stents, when compared to conventional stents, are the elimination of late stent thrombosis, chronic inflammation, and artifacts during noninvasive imaging.Methods: Magnesium-based AMS were deployed in juvenile domestic pig coronary arteries. Angiography, optical coherence tomography (OCT), and intravascular ultrasound (IVUS) were performed before and after implant and then at 28 days and 3 months following stenting. The animals were sacrificed at 28 days or 3 months following stent implantation. Stented vessels were harvested and analyzed ...

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    1-14 of 14
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    1. (12 articles) Ron Waksman
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    Optical Coherence Tomography: A New Imaging Modality for Plaque Characterization and Stent Implantation OCT in Coronary Bifurcations (Book Chapter) Intravascular Ultrasound Versus Optical Coherence Tomography Guidance Serial Observation of Drug-Eluting Absorbable Metal Scaffold Multi-Imaging Modality Assessment Intra-Stent Tissue Evaluation within Bare Metal and Drug-Eluting Stents > 3 Years since Implantation in Patients with Mild to Moderate Neointimal Proliferation Using Optical Coherence Tomography and Virtual Histology Intravascular Ultrasound Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold Intracoronary imaging: see more, better or worse? Impact of procedural characteristics on coronary vessel wall healing following implantation of second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary artery lesions: an optical coherence tomography analysis Serial 3-Dimensional Optical Coherence Tomography Assessment of Jailed Side-Branch by Second-Generation Drug-Eluting Absorbable Metal Scaffold (From the BIOSOLVE-II Trial) Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window Avinger Announces Full Commercial Launch of Pantheris SV Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hosptial