1. Articles from Alexey Popov

    1-4 of 4
    1. Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from bovine lateral femur and stored in phosphate-buffered saline at -20°C until clearing. Monitoring of clearing process was performed using high-speed spectral-domain OCT system providing axial resolution of 5.8 ...

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    2. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes visible after 15 min of optical clearing that enabling non-invasive estimation of its roughness: S a = 10 ± 1 µm. The results show that for 0.9 mm thick cartilage optical ...

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    3. Gold nanostructures for OCT imaging of capillary flow

      Gold nanostructures for OCT imaging of capillary flow

      In this paper, plasmon-resonant nanostructures, such as gold nanostars and their silica-coated composites, were used for enhancement of OCT image contrast of water flows in glass capillaries. The contrasting properties of the synthesized nanostars and nanocomposites with silica shell thickness of about 5 nm and 50 nm were compared in the framework of capillary stasis model. The most intensive signal was detected from the nanocomposites with the thickest silica shell. The nanocomposites were characterized by optical spectroscopy and electron microscopy. Nontoxicity of nanostars and nanocomposites up to ~ 3 mg/mL concentration was showed by MTT assay suggesting practical applications of ...

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    4. Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques

      Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques
      In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000 mg/dl in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is about twice more sensitive than OCT, as well for blood as for Intralipid measurements. In case of TOF technique, glucose sensitivity in Intralipid is higher than in blood. We speculate that all this is associated with longer pathlengths of detected photons in TOF than in OCT, which is confirmed by comparison with Monte Carlo ...
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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) University of Oulu
    2. (4 articles) Matti Kinnunen
    3. (4 articles) Alexander V. Bykov
    4. (3 articles) Valery V. Tuchin
    5. (1 articles) Moscow State University
    6. (1 articles) Saratov State University
    7. (1 articles) Igor V. Meglinski
    8. (1 articles) Alexander V. Priezzhev
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    Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques Gold nanostructures for OCT imaging of capillary flow Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage Optical clearing of articular cartilage: a comparison of clearing agents Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma Optical coherence tomography angiography for identifying choroidal neovascular membranes: a masked study in clinical practice Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography Reconstruction of Optical Coherence Tomography Images Using Mixed Low Rank Approximation and Second Order Tensor Based Total Variation Method