1. Articles from Mingda Han

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    1. Blood Flow Dynamics of One Cardiac Cycle and Relationship to Mechanotransduction and Trabeculation during Heart Looping

      Blood Flow Dynamics of One Cardiac Cycle and Relationship to Mechanotransduction and Trabeculation during Heart Looping
      Analyses of form-function relationships during heart looping are directly related to technological advances. Recent advances in 4-D optical coherence tomography (OCT) permit observations of cardiac dynamics at high speed acquisition rates and high resolution. Real-time observation of the avian stage 13 looping heart reveals that interactions between the endocardial and myocardial compartments are more complex than previously depicted. Here we applied 4-D OCT to elucidate the relationships of the endocardium, myocardium, and cardiac jelly compartments in a single cardiac cycle during looping. Six cardiac levels along the longitudinal heart tube were each analyzed at 15 time points from diastole to ...
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