1. Articles from PASI P. KARJALAINEN

    1-6 of 6
    1. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cell–capturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the vascular response are needed. Methods In a prospective randomized multicenter clinical trial, 60 patients with acute coronary syndromes were randomized 1:1 to COMBO or CoCr EES implantation. The ...

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    2. Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation

      Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation

      Optical coherence tomogra Background/Objectives Optical coherence tomography (OCT) is widely used for evaluation of healing response to stent implantation. We sought to test the agreement between the 1-mm and 0.6-mm sampling intervals for assessment of the percentage of uncovered and malapposed struts by OCT. Methods Thirty­eight patients presenting with acute coronary syndrome were randomized to receive either a titanium­nitride­oxide­coated stent (n = 19) or an everolimus­eluting stent (n = 19). Neointimal strut coverage and strut apposition were evaluated by OCT at 2­month follow­up. Two independent investigators performed offline OCT image analysis at 1 ...

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    3. Vascular Healing Early After Titanium-Nitride-Oxide-Coated Stent Implantation Assessed by Optical Coherence Tomography

      Vascular Healing Early After Titanium-Nitride-Oxide-Coated Stent Implantation Assessed by Optical Coherence Tomography

      The efficacy and safety of titanium -nitride-oxide-coated bioactive stents (BASs) were demonstrated in prior studies. In a prospective registry, we sought to explore the extent of neointimal coverage of stent struts by optical coherence tomography (OCT) at 30 days following the implantation of BASs in an unselected non-diabetic population. Methods. We enrolled 20 consecutive non-diabetic patients who underwent BAS implantation. OCT images were obtained at 30-day follow-up. Binary stent strut coverage was defined as the number of covered struts as a percentage of all analyzed struts. Results. Patients underwent OCT examination at an average of 30.5 ± 5.7 days ...

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    4. Feasibility and safety of frequency-domain optical coherence tomography for coronary artery evaluation: a single-center study

      Feasibility and safety of frequency-domain optical coherence tomography for coronary artery evaluation: a single-center study

      We assessed the feasibility and safety of frequency-domain optical coherence tomography (FD–OCT) in a variety of indications. We conducted a retrospective analysis of all FD–OCT examinations performed for research and clinical indications, including stable angina, acute coronary syndromes, diagnostic procedures and percutaneous coronary intervention (PCI), at the Satakunta Central Hospital (Pori, Finland) between August 12th 2009 and February 9th 2011. All pullbacks were screened for image quality. Data on complications and clinical implications of examinations was obtained from patient records. The mean age of the patients was 65.9 ± 10.9 years (81.7 % males). A total of ...

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    5. Stent strut coverage of titanium-nitride-oxide coated stent compared to paclitaxel-eluting stent in acute myocardial infarction: TITAX-OCT study

      Stent strut coverage of titanium-nitride-oxide coated stent compared to paclitaxel-eluting stent in acute myocardial infarction: TITAX-OCT study

      Drug-eluting stents (DES) have reduced the rate of restenosis but recent studies have raised concern over the risk of late stent thrombosis (LST). Incomplete stent endothelialization and delayed vascular healing have been associated with LST. The titanium-nitride-oxide coated bio-active stent (BAS) has shown promising results in patients with acute coronary syndromes, but there is little long-term optical coherence tomography (OCT) data comparing BAS with DES. The TITAX-AMI trial is a prospective, randomized, multicenter trial comparing BAS to paclitaxel-eluting stent (PES) in 425 patients with acute myocardial infarction. A total of 18 patients (9 per group) with no major cardiac events ...

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    6. Optical coherence tomography: On the way to decipher the ‘Rosetta stone’

      Optical coherence tomography: On the way to decipher the ‘Rosetta stone’

      Optical coherence tomography is an exciting light-based imaging modality with a much higher axial resolution as compared with intravascular ultrasound. The diagnostic value of optical coherence tomography resides in its ability to provide information on the stent interaction with the vessel wall at the level of individual struts. Chief clinical implications include evaluating strut neointimal coverage and strut malapposition following coronary stenting. This Editorial covers the basics of optical coherence tomography, its established and potential clinical implications, probable caveats and downsides, in addition to a future perspective, all in view of the late-breaking peer-reviewed literature.

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    1-6 of 6
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    Stent strut coverage of titanium-nitride-oxide coated stent compared to paclitaxel-eluting stent in acute myocardial infarction: TITAX-OCT study Optical coherence tomography: On the way to decipher the ‘Rosetta stone’ Feasibility and safety of frequency-domain optical coherence tomography for coronary artery evaluation: a single-center study Vascular Healing Early After Titanium-Nitride-Oxide-Coated Stent Implantation Assessed by Optical Coherence Tomography Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical Optical Coherence Tomography Angiography in Myopic Patients Quantification of retinal microvasculature and neurodegeneration changes in branch retinal vein occlusion after resolution of cystoid macular edema on optical coherence tomography angiography Machining head for a laser machining device Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease Detection of and validation of shadows in intravascular images Automated intravascular plaque classification