1. Articles from R. W. Kirk

    1-2 of 2
    1. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    2. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Western Australia
    2. (2 articles) Dirk Lorenser
    3. (2 articles) Xiaojie Yang
    4. (2 articles) David D. Sampson
    5. (2 articles) Rodney W. Kirk
    6. (1 articles) Robert A. McLaughlin
    7. (1 articles) Sapienza University of Rome
    8. (1 articles) Jikei University School of Medicine
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY IMAGE CONTRAST AND BACKGROUND COLOR SETTINGS INFLUENCE IDENTIFICATION OF RETINAL STRUCTURES Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia Associations between the Framingham Risk Score and coronary plaque characteristics as assessed by three-vessel optical coherence tomography Perimeter Medical Imaging Receives FDA Clearance for OTISTM Optical Tissue Imaging System Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography Outer Retinal Layers Alterations in Chronic Central Serous Chorioretinopathy: Spectral Domain-OCT and Fundus Autofluorescence Findings Recanalization of Organized Thrombi Demonstrated by Coronary CT Angiography Compared With OCT An All-Fiber-Optic Combined System of Noncontact Photoacoustic Tomography and Optical Coherence Tomography The Repeatability of Retinal Layer Thickness Measurements with Spectral-Domain Optical Coherence Tomography in Normal Eyes