1. Articles from R. W. Kirk

    1-2 of 2
    1. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    2. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-2 of 2
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  2. Topics in the News

    1. (4 articles) Carl Zeiss Meditec
    2. (4 articles) Zeiss Cirrus HD-OCT
    3. (3 articles) Harvard University
    4. (2 articles) University of Western Australia
    5. (2 articles) Dirk Lorenser
    6. (2 articles) Xiaojie Yang
    7. (2 articles) David D. Sampson
    8. (2 articles) Rodney W. Kirk
    9. (2 articles) Massachusetts Eye and Ear Infirmary
    10. (2 articles) UCLA
    11. (2 articles) Srinivas R. Sadda
    12. (2 articles) Vikas Chopra
    13. (1 articles) Robert A. McLaughlin
    14. (1 articles) Tokyo Medical & Dental University
    15. (1 articles) Junya Shite
    16. (1 articles) Ivan T. Lima
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe University of Maryland Receives NIH Grant for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles Pediatric Sleep-Related Breathing Disorders: Advances in imaging and computational modeling. Extreme optical confinement in a slotted photonic crystal waveguide Optic Nerve Head Parameters in Healthy Turkish Population Using Spectral Domain Optical Coherence Tomography Ex-vivo multi-modal microscopy of healthy skin Accelerated simulation of optical coherence tomography of objects with arbitrary spatial distributions Effect of Angle of Incidence on Anterior Chamber Angle Metrics From Optical Coherence Tomography Anterior Segment Optical Coherence Tomography in the Long-Term Follow-up and Detection of Glaucoma in Boston Type I Keratoprosthesis Correlation and Agreement Between Cirrus HD-OCT "RNFL Thickness Map" and Scan Circle Retinal Nerve Fiber Layer Thickness Measurements Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography