1. Articles from Edward Baraghis

    1-2 of 2
    1. Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow

      Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow

      Endothelial dysfunction and oxidative stress contribute to the atherosclerotic process that includes stiffening of large peripheral arteries. In contrast, we previously reported a paradoxical increase in cerebrovascular compliance in LDLr-/-: hApoB+/+ atherosclerotic (ATX) mice. We hypothesized that prevention of cerebral artery endothelial function with a chronic dietary antioxidant intake would normalize the changes in cerebral artery wall structure and biomechanics and prevent the decline in basal cerebral blood flow (CBF) associated with atherosclerosis. Three-month old ATX mice were treated, or not, for 3 months with the polyphenol (+)-catechin (CAT, 30 mg/kg/day) and compared to wild-type (WT) controls. In ...

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    2. Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice

      Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice

      Severe dyslipidemia and the associated oxidative stress, could accelerate the age-related decline in cerebrovascular endothelial function and cerebral blood flow (CBF), leading to neuronal loss and impaired learning abilities. We hypothesized that a chronic treatment with the polyphenol catechin would prevent endothelial dysfunction, maintain CBF responses and protect learning abilities in atherosclerotic (ATX) mice. We treated ATX (C57Bl/6-LDLR-/-hApoB+/+; 3 month-old, m/o) mice with catechin (30 mg/kg/day) for 3 months, and C57Bl/6 (WT, 3 and 6-m/o) mice were used as controls. ACh- and flow-mediated dilations (FMD) were recorded in pressurized cerebral arteries. Basal CBF ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Polytechnique Montreal
    2. (2 articles) Frédéric Lesage
    3. (2 articles) Simon Fraser University
    4. (2 articles) Marinko V. Sarunic
    5. (2 articles) Myeong Jin Ju
    6. (1 articles) University of Montreal
    7. (1 articles) University of British Columbia
    8. (1 articles) Oregon Health & Science University
    9. (1 articles) National Research Council Canada
    10. (1 articles) University of Toronto
    11. (1 articles) I. Alex Vitkin
    12. (1 articles) Yifan Jian
    13. (1 articles) Costel Flueraru
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