1. Articles from Richard M. AWDEH

    1-3 of 3
    1. Optical coherence contrast imaging using gold nanorods in living mice eyes

      Optical coherence contrast imaging using gold nanorods in living mice eyes

      Background Optical Coherence Tomography (OCT) is a powerful imaging modality to visualize tissue structures, with axial image pixel resolution as high as 1.6 um in tissue. However, OCT is intrinsically limited to providing structural information as the OCT contrast is produced by optically scattering tissues. Methods Here we demonstrate gold nanorods (GNRs) injected into the anterior chamber (AC) and cornea of mice eyes can create a significant OCT signal and hence can be used as a contrast agent for in vivo OCT imaging. Results We show that a low dose of 30 nM of GNRs (13 nm in diameter ...

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    2. Molecular Histopathology Using Gold Nanorods and Optical Coherence Tomography

      Molecular Histopathology Using Gold Nanorods and Optical Coherence Tomography

      Purpose:To examine the novel application of a commercially available optical coherence tomography (OCT) system towards molecular histopathology using gold nanorod (GNR) linked antibodies as a functionalized contrast agent to evaluate ocular surface squamous neoplasia (OSSN). Methods:GNRs were synthesized and covalently attached to anti-glucose transporter-1 (GLUT-1) antibodies via carbodiimide chemistry. Three specimens from each of 3 distinct categories of human conjunctival tissue were selected for analysis, including conjunctiva without epithelial atypia (controls); conjunctival intraepithelial neoplasia: carcinoma in situ (CIS); and conjunctival squamous cell carcinoma (SCC). Tissue sections were incubated initially with GNR tagged anti-GLUT-1 antibodies and then with a ...

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    3. System And Method For Molecular In Vivo Imaging And Theranostics

      System And Method For Molecular In Vivo Imaging And Theranostics

      Systems and methods of characterizing biological tissues are provided. Tn the systems and methods, a first optical coherence tomography ( OCT) image of a selected portion of biological tissues combined with a plurality of nanoparticϊεs is obtained, where the plurality of nanoparticlεs are configured to bind to one or more types of biological molecules in the biological tissues and to produce contrast during OCT imaging. The systems and methods also include estimating a first distribution of the plurality of nanoparticles in the selected portion based on the first OCT image and characterizing the selected portion with respect to the ...

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    1-3 of 3
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    1. (3 articles) University of Miami
    2. (2 articles) Stanford University
    3. (2 articles) Adam de la Zerda
    4. (1 articles) National Institutes of Health
    5. (1 articles) Marco B. Ruggeri
    6. (1 articles) Carl Zeiss Meditec
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