All Articles from Josep Gomez-Lara -Optical Coherence Tomography News

Articles from Josep Gomez-Lara

1-24 of 24
1. Impact of diabetes mellitus on vascular healing process after everolimus-eluting stent implantation: An optical coherence tomography study
  
  Explore ScienceDirect Apr 22 2021 Cardiology
  
  Background/purpose: To study the impact of diabetes mellitus (DM) on vascular healing process after implantation of everolimus-eluting stent (EES). Methods/materials: Data from 3 prospective studies (HEAL-EES, REVER, and RESERVOIR), including patients with EES implantation and OCT follow-up, were merged. Differences in vascular healing process assessed by OCT were compared between DM and non-DM using generalized estimating equations. Neointimal proliferation, neointimal signal pattern (high, low, and layered), and uncovered/malapposed struts were evaluated. Results: A total of 96 lesions (61 DM lesions and 35 non-DM lesions) were included. Mean OCT follow-up time was 8.9 ± 1.5 months and ...
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2. Early coronary healing in ST segment elevation myocardial infarction: sirolimus-eluting stents vs. drug-coated balloons after bare-metal stents. The PEBSI-2 optical coherence tomography randomized study
  
  Explore LWW Online Apr 8 2021 Cardiology
  
  Objectives: Drug-coated balloons (DCBs) have theoretical advantages over drug-eluting stents (DESs) to facilitate stent healing. We studied whether, in patients undergoing primary coronary interventions (pPCIs), a strategy of DCB after bare-metal stent improves early healing as determined by optical coherence tomography (OCT) compared with new-generation DES. Methods: pPCI patients were randomized (1:1) to treatment with new-generation sirolimus-eluting stents (DES group) or DCB-strategy. Vessel healing was assessed by OCT at 90 days. Results: Fifty-three patients were randomized (26 DES vs. 27 DCB). At 90 days, both strategies showed a low rate of uncovered struts (3.2 vs. 3.2%, P ...
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3. First in man evaluation of a sirolimus-eluting stent with abluminal fluoropolymeric/triflusal coating with ultrathin struts by OCT at 9 months follow up. The PROMETHEUS study
  
  Explore ScienceDirect Jan 4 2021 Cardiology
  
  Objectives We sought to investigate stent healing and neointimal hyperplasia with ihtDEStiny drug-eluting stent (DES) by optical coherence tomography (OCT) examination conducted 9 months after implantation. Background The currently used DES present certain features that have been linked separately to their better performance in terms of efficacy and safety. Methods First-in-man, prospective and multicenter study including patients treated with ihtDEStiny stent undergoing OCT examination at 9 months follow up. The ihtDEStiny stent is a sirolimus eluting stent with an oval shape ultrathin struts (68 μm) and an abluminal coating of a fluoropolymer containing the antiplatelet agent triflusal. Primary endpoint was ...
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  Mentions: Hospital Universitario La Paz
4. Longitudinal neointimal distribution pattern after Everolimus-eluting stent implantation: Insights from optical coherence tomography study
  
  Explore ScienceDirect Nov 12 2020 Cardiology
  
  Background/purpose: Everolimus-eluting stents (EES) are established as latest generation drug eluting stents. However, optical coherence tomography (OCT) assessment of neointimal distribution after EES implantation is lacking. We aimed to assess the longitudinal neointimal distribution pattern after EES implantation using OCT. Methods: Data from 3 prospective studies (HEAL-EES, REVER and RESERVOIR), including patients with EES implantation and OCT follow-up study, were merged. Analyzed stents were divided into 3 segments of equal length (distal, medial, proximal). Longitudinal neointimal distribution patterns were compared between the 3 segments using generalized estimating equation. Neointimal thickness (NIT), neointimal area obstruction, and uncovered or malapposed struts ...
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  Mentions: San Carlos University Hospital
5. Optical Coherence Tomography for the Diagnosis of Exercise-Related Acute Cardiovascular Events and Inconclusive Coronary Angiography
  
  Explore Hindawi Publishing Corporation Jul 29 2020 Cardiology
  
  Objectives . The aim of this study is to assess the utility of optical coherence tomography (OCT) in patients with exercise-related acute coronary syndrome (ACS) presenting with inconclusive angiographic findings. Background . Regular physical activity reduces the incidence of cardiovascular events. Nevertheless, the risk of ACS or sudden cardiac death (SCD) increases during sport. In adults older than 35 years, exercise-related ACS or SCD is associated with plaque rupture, but not infrequently patients present ambiguous angiographic findings. Methods . Between September 2015 and January 2020, patients admitted for ACS or SCD triggered by physical exertion and with coronary stenosis ≤50% were included in ...
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6. Second-generation drug-eluting absorbable metal scaffold target-lesion revascularization: an optical coherence tomography case series study and literature review
  
  Explore eurointervention.pcronline.com Sep 7 2019 Cardiology
  
  Bioresorbable scaffolds (BRS) were introduced into clinical practice to overcome long-term limitations of drug-eluting stents (DES), but they were instead associated with a high rate of target lesion revascularization (TLR) and thrombosis. Whereas scaffold discontinuity was the most frequent mechanism for polymeric-BRS TLR1, there are no studies on the causes of second-generation drug-eluting absorbable metal scaffold (MgBRS) TLR (Magmaris, BIOTRONIK, Bulach, Switzerland). We sought to determine the optical coherence tomography (OCT) findings in patients who experienced a MgBRS TLR. Moreover, we performed a systematic review of the reported cases.
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  Mentions: University of Valencia
7. Bioresorbable Vascular Scaffolds in coronary chronic total occlusions. Clinical, vasomotor and optical coherence tomography findings at 3-year follow-up (ABSORB-CTO study)
  
  Explore eurointervention.org Oct 9 2018 Cardiology
  
  Aims: Percutaneous treatment of coronary chronic total occlusion (CTO) is associated with important arterial remodelling after successful recanalization. Bioresorbable vascular scaffold (BVS) implantation in CTO has been shown feasible and can be of interest when the scaffold achieves complete bioresorption. We sought to evaluate the 3-year results in terms of clinical events, serial imaging outcomes and the vasomotion response in CTO lesions successfully treated with BVS. Methods and results: A total of 33 patients (35 CTO lesions) successfully treated with BVS were included in ABSORB-CTO study. Clinical outcomes, quantitative coronary angiography (QCA) and optical coherence tomography (OCT) assessment were analysed ...
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8. Five-Year Optical Coherence Tomography in Patients With ST-Segment–Elevation Myocardial Infarction Treated With Bare-Metal Versus Everolimus-Eluting Stents
  
  Explore Circulation Oct 8 2016 Cardiology
  
  Background— The main causes of late (>1 month) stent thrombosis (ST) are stent uncoverage, malapposition, and neoatherosclerosis. First-generation drug-eluting stents were associated with higher rate of late ST compared with bare-metal stents (BMS), especially in patients with ST-segment–elevation myocardial infarction. Second-generation everolimus-eluting stents (EES) have shown similar rate of late ST than BMS. The aims of the study are to compare the ratio of uncovered to total struts per cross-section ≥30% and other optical coherence tomographic findings associated with ST between EES and BMS in patients with ST-segment–elevation myocardial infarction at 5 years. Methods and Results— One hundred ...
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9. Effect of the Endothelial Shear Stress Patterns on Neointimal Proliferation Following Drug-Eluting Bioresorbable Vascular Scaffold Implantation : An Optical Coherence Tomography Study
  
  Explore ScienceDirect Feb 18 2014 Cardiology
  
  Objectives The goal of this study was to investigate the effect of endothelial shear stress (ESS) on neointimal formation following an Absorb bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) implantation. Background Cumulative evidence, derived from intravascular ultrasound–based studies, has demonstrated a strong association between local ESS patterns and neointimal formation in bare-metal stents, whereas in drug-eluting stents, there are contradictory data about the effect of ESS on the vessel wall healing process. The effect of ESS on neointimal development following a bioresorbable scaffold implantation remains unclear. Methods Twelve patients with an obstructive lesion in a relatively straight ...
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  Mentions: Brigham and Women’s Hospital Harvard University Abbott
10. Reproducibility of qualitative assessment of stent struts coverage by optical coherence tomography
  
  Explore SpringerLink Home Mar 13 2012 Cardiology
  
  Abstract Assessment of stent strut coverage by optical coherence tomography (OCT) is not standardized. The methodology most commonly used is based on a visual binary qualitative assessment (strut covered or not). However, the influence of magnification (zoom setting) to the inter- and intra-observer agreements has not yet been evaluated. Aim of our study was therefore to evaluate the agreements of this approach, taking into account various zoom settings. 126 struts from 10 selected frames were independently evaluated by four observers using a stepwise approach increasing the zoom setting as following: (1) full view of the lumen (FV), (2) half view ...
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  Mentions: Abbott Erasmus University
11. Head to head comparison of optical coherence tomography, intravascular ultrasound echogenicity and virtual histology for the detection of changes in polymeric struts over time: insights from the ABSORB trial
  
  Explore eurointervention.org Dec 27 2011 Cardiology
  
  Aims: To analyse and to compare the changes in the various optical coherence tomography (OCT), echo-genicity intravascular ultrasound virtual histology (VH) of the everolimus-eluting bioresorbable scaffold (ABSORB) degradation parameters during the first 12 months after ASOERB implantation.
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  Mentions: Abbott University of Bern Erasmus University
12. Head-to-Head Comparison of the Neointimal Response Between Metallic and Bioresorbable Everolimus-Eluting Scaffolds Using Optical Coherence Tomography
  
  Explore interventions.onlinejacc.org Dec 19 2011 Cardiology
  
  The metallic everolimus drug-eluting stents (DES) and polymeric everolimus bioresorbable vascular scaffolds (BVS) are coated with the same antiproliferative drug. It is uncertain if, during the bioresorption process, the neointimal response of everolimus BVS differs from that of everolimus DES. A total of 31 lesions treated with a single everolimus BVS, and 19 lesions treated with everolimus DES and imaged with optical coherence tomography at 1 year, were investigated. Neointimal response was assessed as a percentage of uncovered struts, neointimal thickness, in-stent/scaffold area obstruction, and pattern of neointima. Both scaffolds presented with similar neointimal response. However, the everolimus BVS ...
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  Mentions: Abbott Erasmus University Aarhus University
13. Three-dimensional optical frequency domain imaging in conventional percutaneous coronary intervention: the potential for clinical application
  
  Explore Oxford Journals Nov 23 2011 Cardiology
  
  Two-dimensional (2D) frequency domain optical coherence tomography (FD-OCT) has enhanced our understanding of coronary atherosclerotic disease and is increasingly being used in conventional percutaneous coronary intervention (PCI) to elucidate mechanisms of disease and improve our understanding of complex coronary anatomy. Since the first report of three-dimensional (3D) OCT applied in human coronary vessels,1 the technology has rapidly progressed.2–10 Currently, the main limitation of this technology is the need for off-line creation of 3D reconstructions—prototypes of current generation ‘real time’ (i.e. available peri-procedurally at the ‘push-of-a-button’) remain experimental, work in progress, and are limited by relatively ...
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  Mentions: Terumo Corporation Erasmus University
14. Angiographic maximal luminal diameter and appropriate deployment of the everolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography: an ABSORB cohort B trial sub-study
  
  Explore eurointervention.org Oct 30 2011 Cardiology
  
  Aims: Bioresorbable vascular scaffolds (BVS) present different mechanical properties as compared to metallic platform stents. Therefore, the standard procedural technique to achieve appropriate deployment may differ. Methods and results: Fifty-two lesions treated with 3x18 mm BVS were imaged with optical coherence tomography (OCT) post-implantation and screened for parameters suggestion non-optimal deployment.
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  Mentions: Abbott Erasmus University Aarhus University
15. Serial Analysis of the Malapposed and Uncovered Struts of the New Generation of Everolimus-Eluting Bioresorbable Scaffold With Optical Coherence Tomography
  
  Explore interventions.onlinejacc.org Sep 19 2011 Cardiology
  
  Objectives The aim of this study is to assess the serial changes in strut apposition and coverage of the bioresorbable vascular scaffolds (BVS) and to relate this with the presence of intraluminal masses at 6 months with optical coherence tomography (OCT). Background Incomplete strut/scaffold apposition (ISA) and uncovered struts are related to a higher risk of scaffold thrombosis. Bioresorbable vascular scaffolds can potentially avoid the risk of scaffold thrombosis because of its complete resorption. However, during the resorption period, the risk of scaffold thrombosis is unknown. Methods OCT was performed in 25 patients at baseline and 6 months. Struts ...
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  Mentions: Aarhus University
16. 3D Reconstructions of Optical Frequency Domain Imaging to Improve Understanding of Conventional PCI
  
  Explore imaging.onlinejacc.org Sep 14 2011 Cardiology
  
  Letter To The Editor
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  Mentions: Erasmus University
17. New Insights Into the Coronary Artery Bifurcation: Hypothesis-Generating Concepts Utilizing 3-Dimensional Optical Frequency Domain Imaging
  
  Explore interventions.onlinejacc.org Aug 15 2011 Cardiology
  
  Coronary artery bifurcations are a common challenging lesion subset accounting for approximately 10% to 20% of all percutaneous coronary interventions. The provisional T-stenting approach is generally recommended as the first-line management of most lesions. Carina shift is suggested to be the predominant mechanism of side-branch pinching during provisional T-stenting and has been indirectly inferred from bench work and other intravascular imaging modalities. Offline 3-dimensional (3D) reconstructions of patients studied in the first-in-man trial of the high-frequency (160 frames/s) Terumo optical frequency domain imaging system were undertaken using volume-rendering software. Through a series of 3D reconstructions, several novel hypothesis-generating concepts ...
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  Mentions: Terumo Corporation Erasmus University
18. Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from benchwork to clinical application
  
  Explore eurointervention.org Aug 13 2011 Cardiology
  
  Fully bioresorbable everolimus-eluting vascular scaffolds (BVS: Abbott Vascular) are a novel approach to treating coronary lesions. The ABSORB cohort A and cohort B trials investigated the implantation of 3 mm BVS, up to a maximum length of 18 mm, in simple lesions only, The implantation of overlapping BVS in longer lesions has not previously been reported.
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  Mentions: Cardiovascular Research Foundation Abbott Erasmus University
19. Assessment of Coronary Atherosclerosis Progression and Regression at Bifurcations Using Combined IVUS and OCT
  
  Explore imaging.onlinejacc.org Jul 11 2011 Cardiology
  
  Objectives The aim of this study was to evaluate the progression of atherosclerotic coronary plaques at bifurcations, using combined intravascular ultrasound–virtual histology (IVUS-VH) and optical coherence tomography (OCT). Background Pathological findings reveal that atherosclerotic plaques characterized by the presence of large necrotic cores (NCs) with fibrous cap thicknesses < 65 µm are more prone to rupture. Accuracy in the detection of high-risk plaques could be improved by the combined use of IVUS-VH and OCT. Methods IVUS-VH and OCT are 2 imaging modalities with different lateral resolutions and different depths of penetration. To provide a precise matching of the images, bifurcations ...
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  Mentions: University of Perugia Erasmus University
20. NIRS and IVUS for Characterization of Atherosclerosis in Patients Undergoing Coronary Angiography
  
  Explore imaging.onlinejacc.org Jun 18 2011 Cardiology
  
  Objectives: The aim of this study was to compare the findings of near-infrared spectroscopy (NIRS), intravascular ultrasound (IVUS) virtual histology (VH), and grayscale IVUS obtained in matched coronary vessel segments of patients undergoing coronary angiography. Background: Intravascular ultrasound VH has been developed to add tissue characterization to the grayscale IVUS assessment of coronary plaques. Near-infrared spectroscopy is a new imaging technique able to identify lipid core-containing coronary plaques (LCP). Methods: We performed NIRS and IVUS-VH pullbacks in a consecutive series of 31 patients with a common region of interest (ROI) between 2 side branches. For each ROI, we analyzed the ...
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  Mentions: Academic Medical Center at the University of Amsterdam Erasmus University InfraReDx
21. Agreement and reproducibility of gray-scale intravascular ultrasound and optical coherence tomography for the analysis of the bioresorbable vascular scaffold
  
  Explore Wiley Online Library Apr 26 2011 Cardiology
  
  Objective:To report the agreement between grey-scale intravascular ultrasound (GS-IVUS) and optical coherence tomography (OCT) in assessing the bioresorbable vascular scaffolds (BVS) structures and their respective reproducibility.Background:BVS are composed of an erodible polymer. Ultrasound and light signals backscattered from polymeric material differs from metallic stents using GS-IVUS and OCT.Methods:Forty-five patients included in the ABSORB trial were treated with a 3.0x18 mm BVS and imaged with GS-IVUS 20 MHz and OCT post-implantation. Qualitative (ISA, side-branch struts, protrusion and dissections) and quantitative (number of struts, lumen and scaffold area) measurements were assessed by two investigators. The agreement ...
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  Mentions: Erasmus University
22. Evaluation with in vivo optical coherence tomography and histology of the vascular effects of the everolimus-eluting bioresorbable vascular scaffold at two years following implantation in a healthy porcine coronary artery model: implications of pilot resu
  
  Explore SpringerLink Home Apr 20 2011 Cardiology
  
  To quantify with in vivo OCT and histology, the device/vessel interaction after implantation of the bioresorbable vascular scaffold (BVS). We evaluated the area and thickness of the strut voids previously occupied by the polymeric struts, and the neointimal hyperplasia (NIH) area covering the endoluminal surface of the strut voids (NIH(EV)), as well as the NIH area occupying the space between the strut voids (NIH(BV)), in healthy porcine coronary arteries at 2, 3 and 4 years after implantation of the device. Twenty-two polymeric BVS were implanted in the coronary arteries of 11 healthy Yucatan minipigs that underwent OCT ...
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  Mentions: National Institutes of Health Cardiovascular Research Foundation Abbott
23. Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from bench-work to clinical application
  
  Explore eurointervention.org Jan 27 2011 Cardiology
  
  Fully bioresorbable everolimus-eluting vascular scaffolds are a novel approach to treating coronary lesions. The ABSORB cohort A and cohort B trials investigated the implantation of 3 mm BV, up to a maximum length of 18 mm, in simple lesions only.
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  Mentions: Abbott Erasmus University
24. A comparative assessment by optical coherence tomography of the performance of the first and second generation of the everolimus-eluting bioresorbable vascular scaffolds
  
  Explore Oxford Journals Dec 5 2010 Cardiology
  
  Aims The first generation of the everolimus-eluting bioresorbable vascular scaffold (BVS 1.0) showed an angiographic late loss higher than the metallic everolimus-eluting stent Xience V due to scaffold shrinkage. The new generation (BVS 1.1) presents a different design and manufacturing process than the BVS 1.0. This study sought to evaluate the differences in late shrinkage, neointimal response, and bioresorption process between these two scaffold generations using optical coherence tomography (OCT). Methods and results A total of 12 lesions treated with the BVS 1.0 and 12 selected lesions treated with the revised BVS 1.1 were imaged ...
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  Mentions: Erasmus University
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