1. Articles from Monica T. Hinds

    1-10 of 10
    1. Alterations in Pulse Wave Propagation Reflect the Degree of Outflow Tract Banding in HH18 Chicken Embryos

      Alterations in Pulse Wave Propagation Reflect the Degree of Outflow Tract Banding in HH18 Chicken Embryos

      Hemodynamic conditions play a critical role in embryonic cardiovascular development, and altered blood flow leads to congenital heart defects. Chicken embryos are frequently used as models of cardiac development, with abnormal blood flow achieved through surgical interventions such as outflow tract (OFT) banding, in which a suture is tightened around the heart OFT to restrict blood flow. Banding in embryos increases blood pressure and alters blood flow dynamics, leading to cardiac malformations similar to those seen in human congenital heart disease. In studying these hemodynamic changes, synchronization of data to the cardiac cycle is challenging, and alterations in the timing ...

      Read Full Article
    2. Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography

      Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography
      Matrix remodeling plays a fundamental role in physiological and pathological processes, as well as in tissue engineering applications. In this paper, optical coherence tomography (OCT), a non-destructive optical imaging technology, was used to image collagen gel remodeling by smooth muscle cells (SMCs). The optical scattering properties of collagen–SMC gels were characterized quantitatively by fitting OCT data to a theoretical model. Matrix remodeling over 5 days produced a 10-fold increase in the reflectivity of the collagen gels, corresponding to a decrease in scattering anisotropy from 0.91 to 0.46. The increase in reflectivity was corroborated in confocal mosaic images ...
      Read Full Article
    3. Quantitative characterization of developing collagen gels using optical coherence tomography

      Quantitative characterization of developing collagen gels using optical coherence tomography
      Nondestructive optical imaging methods such as optical coherence tomography (OCT) have been proposed for characterizing engineered tissues such as collagen gels. In our study, OCT was used to image collagen gels with different seeding densities of smooth muscle cells (SMCs), including acellular gels, over a five-day period during which the gels contracted and became turbid with increased optical scattering. The gels were characterized quantitatively by their optical properties, specified by analysis of OCT data using a theoretical model. At 6 h, seeded cell density and scattering coefficient (µs) were correlated, with µs equal to 10.8 cm−1/(106 cells ...
      Read Full Article
    4. Characterizing matrix remodeling in collagen gels using optical coherence tomography

      Characterizing matrix remodeling in collagen gels using optical coherence tomography
      Optical coherence tomography (OCT) has shown promise at non-destructively characterizing engineered tissues such as collagen gels. However, as the collagen gels develop, the OCT images lose contrast of structures as the gels develop, making visual assessment difficult. Our group proposed quantitatively characterizing these gels by fitting the optical properties from the OCT signals. In this paper, we imaged collagen gels seeded with smooth muscle cells (SMCs) over a 5-day period and used the data to measure their optical properties. Our results showed that over time, the reflectivity of the samples increased 10-fold, corresponding to a decrease in anisotropy factor g ...
      Read Full Article
    5. Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds

      Yali Jia, Pierre O. Bagnaninchi, Ying Yang et al. Establishing a relationship between perfusion rate and fluid shear stress in a 3D cell culture environment is an ongoing and challenging task faced by tissue engineers. We explore Doppler optical coherence tomography (DOCT) as a potential imaging tool for in situ monitoring of local fluid flow profi ... [J. Biomed. Opt. 14, 034014 (2009)] published Thu May 14, 2009.

      Read Full Article
    6. Optically characterizing collagen gels made with different cell types

      Optically characterizing collagen gels made with different cell types
      The ability of optical imaging techniques such as optical coherence tomography (OCT) to non-destructively characterize tissue-engineered constructs has generated enormous interest recently. Collagen gels are 3D structures that represent a simple common model of many engineered tissues that contain 2 primary scatterers: collagen and cells. We are testing the ability of OCT data to characterize the remodeling of such collagen-based constructs by 3 different types of cells: vascular smooth muscle cells (SMCs), endothelial cells (ECs), and osteoblasts (OBs). Collagen gels were prepared with SMCs, ECs, and OBs with a seeding density of 1×106 cells/ml; additionally, acellular controls were ...
      Read Full Article
    7. The effect of wavelength on optical properties extracted from images of engineered tissue

      The effect of wavelength on optical properties extracted from images of engineered tissue
      Optical imaging modalities such as confocal microscopy and optical coherence tomography (OCT) are emerging as appealing methods for non-destructive evaluation of engineered tissues. The information offered by such optical imaging methods depends on the wavelength vis-á-vis the optical scattering properties of the sample. These properties affect many factors critical to image analysis in a nonlinear and nontrivial manner. Thus, we sought to characterize the effect wavelength has on the optical properties collagen remodeled by cells at 3 common imaging wavelengths: 488, 633, and 1310 nm. To do this, we seeded smooth muscle cells (SMCs) in soluble collagen gels at a ...
      Read Full Article
    8. Evaluating optical properties of isolated biological scatterers from confocal and low-coherence images

      In biomedical optics applications, the scattering of light by biological tissue is typically mimicked by embedding microparticles such as polystyrene microspheres or TiO within a non-scattering matrix. Such particles are well structured and give rise to uniform optical scattering properties. However ... [Proc. SPIE Int. Soc. Opt. Eng. 6870, 68700G (2008)] published Fri Feb 15, 2008.
      Read Full Article
    9. Optically characterizing vascular tissue constructs made with soluble versus homogenized collagen

      The ability of optical imaging techniques such as optical coherence tomography (OCT) to non-destructively characterize tissue-engineered constructs has generated enormous interest recently. We are testing the hypothesis that OCT data can be used to characterize the cellularity of collagen-based vasc ... [Proc. SPIE Int. Soc. Opt. Eng. 6858, 68580E (2008)] published Wed Feb 6, 2008.
      Read Full Article
    10. Quantitative temporal speckle contrast imaging for tissue mechanics

      Sean J. Kirkpatrick, Donald D. Duncan, Ruikang K. Wang, Monica T. HindsWe demonstrate through a series of simulations that by parameterizing the temporal speckle contrast statistic from a sequence of translating speckle images on a number of experimental constants, the local temporal contrast can be used to quantitatively assess local motion, provided that the spatial ... [J. Opt. Soc. Am. A 24, 3728-3734 (2007)]
      Read Full Article
    1-10 of 10
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (10 articles) Oregon Health & Science University
    2. (7 articles) Steven L. Jacques
    3. (7 articles) David Levitz
    4. (2 articles) Ruikang K. Wang
    5. (1 articles) Ying Yang
    6. (1 articles) Lin An
    7. (1 articles) Donald D. Duncan
    8. (1 articles) Yali Jia
  3. Popular Articles

  4. Picture Gallery

    The effect of wavelength on optical properties extracted from images of engineered tissue Optically characterizing collagen gels made with different cell types Characterizing matrix remodeling in collagen gels using optical coherence tomography Quantitative characterization of developing collagen gels using optical coherence tomography Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography Alterations in Pulse Wave Propagation Reflect the Degree of Outflow Tract Banding in HH18 Chicken Embryos Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma Optical coherence tomography angiography for identifying choroidal neovascular membranes: a masked study in clinical practice