1. Articles from Patricia B. Hoyer

    1-3 of 3
    1. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival study and identify microscopic changes associated with early tumor development. These changes include alterations in tissue microstructure, as seen by OCT, alterations in cellular fluorescence and morphology, as seen by ...

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    2. In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia

      In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia

      Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads ...

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    3. Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis

      Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis
      Determining if an ovarian mass is benign or malignant is an ongoing clinical challenge. The development of reliable animal models provides means to evaluate new diagnostic tools to more accurately determine if an ovary has benign or malignant features. Although sex cord-stromal tumors (SCST) account for 0.1-0.5% of ovarian malignancies, they have similar appearances to more aggressive epithelial cancers and can serve as a prototype for developing better diagnostic methods for ovarian cancer. Optical coherence tomography (OCT) and laser-induced fluorescence (LIF) spectroscopy are non-destructive optical imaging modalities. OCT provides architectural cross-sectional images at near histological resolutions and LIF ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of Arizona
    2. (3 articles) Samuel L. Marion
    3. (3 articles) Jennifer K. Barton
    4. (2 articles) Urs Utzinger
    5. (2 articles) Photini F. S. Rice
    6. (1 articles) University of Connecticut
    7. (1 articles) Molly Brewer
    8. (1 articles) John R. Davis
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