Different vessel response between chronic total occlusions and non-CTO lesion after Sirolimus-eluting stent implantation: a serial optical coherence tomography study

Background We sought to test the feasibility of imaging vulnerable atherosclerotic plaque in vivo using optical coherence tomography (OCT) to assess the value of vulnerable atherosclerotic plaque rabbit model established with a novel way. Methods 30 Rabbits were randomly divided into two groups: Group A (n=15): Balloon injury of carotid artery followed by high cholesterol diet (HCD) for 12 weeks. Group B (n=15): In this group, a thin filter paper slip statured with 10% ferric trichloride was lay between paraffin filter paper and common carotid artery infiltrated for 3 to 5 min. We analysed OCT data including plaque ...
Objectives Assess seriate progress of vulnerable plaque (VP) formation fusing Optical Coherence Tomography (OCT) with histopathological test to confirm what we find in the OCT imaging of vulnerable plaque on established rabbit vulnerable plaque model. Providing early characteristics of the signals displayed by VP in order to prior recognise vulnerable people, in order to give accurate and reasonable therapy. Method 23 New Zealand white rabbits were randomly divided into 4 groups after balloon injurying the intima with subsequently 1% high fat diet. Grouping: Examed at 4 time points: 6 (n=6), 8 (n=5), 10 (n=5), 12 (n=7 ...