1. Articles from Paul C. Beard

    1-6 of 6
    1. All-optical dual photoacoustic and optical coherence tomography intravascular probe

      All-optical dual photoacoustic and optical coherence tomography intravascular probe

      Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 µm to 40 µm; the axial resolution was consistently in the vicinity of 45 µm ...

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    2. All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography

      All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography

      Intravascular (IV) imaging in percutaneous coronary interventions can be invaluable to treat coronary artery disease, to facilitate decision making and to guide stent placement. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are both established IV imaging modalities. However, achieving contrast for specific structures such as lipid plaques can be challenging; with OCT, visualisation is typically limited to tissue depths less than 2 mm. Photoacoustic (PA) imaging provides contrast that is complementary to those of IVUS and OCT, and with previous demonstrations, visualisation of lipid plaques at depths greater than 4 mm has been achieved. In this study, we developed ...

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    3. Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients’ bodies, we applied our multimodality imaging system to investigate several different types of skin conditions. Quantitative vascular analysis is given for each of the dermatological conditions to show the potential ...

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    4. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive ...

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    5. Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Chick embryos are an important animal model for biomedical studies. The visualization of chick embryos, however, is limited mostly to postmortem sectional imaging methods. In this work, we present a dual modality optical imaging system that combines swept-source optical coherence tomography and whole-body photoacoustic tomography, and apply it to image chick embryos at three different development stages. The explanted chick embryos were imaged in toto with complementary contrast from both optical scattering and optical absorption. The results serve as a prelude to the use of the dual modality system in longitudinal whole-body monitoring of chick embryos in ovo .

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    6. Introduction: Advances in Optical Coherence Tomography, Photoacoustic Imaging, and Microscopy

      Introduction: Advances in Optical Coherence Tomography, Photoacoustic Imaging, and Microscopy
      The editors introduce the Biomedical Optics Express feature issue, “Advances in Optical Coherence Tomography, Photoacoustic Imaging, and Microscopy,” which combines three technical areas from the 2010 Optical Society of America (OSA), Biomedical Optics (BIOMED) Topical Meeting held on 11–14 April in Miami, Florida, and includes contributions from conference attendees.
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    1-6 of 6
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  2. Topics in the News

    1. (5 articles) University College London
    2. (3 articles) Medical University of Vienna
    3. (3 articles) Wolfgang Drexler
    4. (2 articles) Michael P. Minneman
    5. (2 articles) Mengyang Liu
    6. (2 articles) Rainer A. Leitgeb
    7. (2 articles) Insight Photonic Solutions
    8. (1 articles) Tufts University
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    10. (1 articles) Xingde Li
    11. (1 articles) University of Milan
    12. (1 articles) Columbia University
    13. (1 articles) Università Vita-Salute San Raffaele
    14. (1 articles) Taner Akkin
    15. (1 articles) Giovanni Gregori
    16. (1 articles) Philip J. Rosenfeld
    17. (1 articles) Giovanni Staurenghi
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    19. (1 articles) Canon Medical Systems
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    Introduction: Advances in Optical Coherence Tomography, Photoacoustic Imaging, and Microscopy Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging All-optical intravascular probe for dual-mode photoacoustic imaging and optical coherence tomography All-optical dual photoacoustic and optical coherence tomography intravascular probe University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation MULTIMODAL IMAGING AND TREATMENT OF SYPHILITIC CHOROIDAL NEOVASCULARIZATION Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber Glioma cell migration dynamics in brain tissue assessed by multimodal optical imaging