1. Articles from Lin Lin

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    1. In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study

      In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study

      Aims Plaque erosion is a significant substrate of acute coronary thrombosis. This study sought to determine in vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction (STEMI). Methods and results A prospective series of 822 STEMI patients underwent pre-intervention optical coherence tomography. Using established diagnostic criteria, 209 had plaque erosion (25.4%) and 564 had plaque rupture (68.6%). Plaque erosion was more frequent in women <50 years when compared with those ≥50 years of age ( P  = 0.009). There was a similar, but less striking, trend in men ( P  = 0.011). Patients with plaque erosion were ...

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    2. Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study

      Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study

      Elevated serum uric acid (SUA) level is known to be a prognostic factor in patients with acute coronary syndrome (ACS). However, the correlation between SUA level and coronary plaque instability has not been fully evaluated. The aim of this study was to investigate the association between SUA level and plaque instability of nonculprit lesions in patients with ACS using optical coherence tomography. A total of 150 patients with ACS who underwent 3-vessel optical coherence tomography were selected. Patients were classified into 3 groups according to tertiles of SUA level. There was a trend towards a thinner fibrous cap (0.15 ...

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    3. Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Acute coronary syndrome (ACS) is the main cause of death worldwide and the leading cause of disease burden in high-income countries. ACS refers to a constellation of clinical symptoms that are compatible with acute myocardial ischemia. It describes a spectrum of clinical manifestations that result from a common pathophysiological process. The most common cause of ACS are rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis. It was thought that a high-resolution imaging modality would be ideal to detect high-risk plaques before their disruption and the formation of an ...

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    4. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52). Fibrous cap thickness (FCT) was measured at its thinnest part 3 times ...

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    5. Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study

      Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study

      Objective: The addition of cystatin C to creatinine in calculating the estimated glomerular filtration rate (eGFR) is known to improve the risk prediction for cardiovascular events. We sought to investigate the associations between eGFRs calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and coronary plaque phenotype by optical coherence tomography. Patients and methods: We analyzed 181 nonculprit plaques from 116 coronary artery disease patients. For each patient, the eGFR was calculated using the CKD-EPIcreatinine, CKD-EPIcystatin C, and CKD-EPIcombination equations. Patients were divided into three categories according to the eGFR calculated by each equation (>=90, 60-89, and <60 ml ...

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    6. Enhancement of coherent optical signal from tissue phantom by gold nanorods in near-infrared range

      Enhancement of coherent optical signal from tissue phantom by gold nanorods in near-infrared range

      To investigate gold nanorods as a contrast agent to enhance signal to noise ratio(SNR) and contrast of spectroscopic optical coherence tomography imaging of the turbid tissue sample, suspensions of silica coated plasmon resonant gold nanorods (GNRs) and biological dye(India ink) were used in gelatin-based phantoms. With the same background scattering condition caused by TiO 2 microspheres, samples of single and double layers were fabricated and test. By comparison of the signal to noise ratio and slop of the depth-dependent signal, some different properties appeared between nanoparticle and biological dye. Unlike simple absorption of ink, GNRs have narrow absorption ...

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    7. Simulation of coherent properties of photons in scattering medium for optical coherence tomograph

      Simulation of coherent properties of photons in scattering medium for optical coherence tomograph

      Monte Carlo model of optical coherence tomography is developed for simulation of photon transport in half infinite homogenous media. The procedure is accelerated by scaling the baseline data from standard Monte Carlo calculation in turbid media with arbitrary optical parameters. Gaussian beam is modeled by hyperboloid of one sheet for actual condition to obtain distribution of photons on sample surface. Depth dependence coherent signal and photons distribution are calculated in this way, which is important to reconstruction of optical parameters by inverse Monte Carlo. Numerical results have verified this method in turbid medium of different optical parameters with acceptable relative ...

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    8. Signal and noise analysis of optical coherence tomography in highly scattering material at 1550nm

      Signal and noise analysis of optical coherence tomography in highly scattering material at 1550nm
      The signal and noise properties of standard time domain optical coherence tomography system are analyzed in near-infrared region based on extended Huygens-Fresnel principle. The signal-to-noise ratio and maximum probing depth are estimated for scattering media with discontinuity plane inside. In numerical simulation, the relationship between coherent signal and scattering coefficients, and depth dependence SNR are calculated. The difference between specular and diffuse reflection is given out and analyzed. Numerical result is verified by well established experiment with different concentration mixture solution of IntralipidTM, from 1% to 15%. The OCT system consists of fiber Michelson interferometer and 1550 nm ASE optical ...
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    1-8 of 8
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    Signal and noise analysis of optical coherence tomography in highly scattering material at 1550nm Simulation of coherent properties of photons in scattering medium for optical coherence tomograph Enhancement of coherent optical signal from tissue phantom by gold nanorods in near-infrared range Chronic kidney disease predicts coronary plaque vulnerability: an optical coherence tomography study Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome Correlation of Serum Uric Acid Levels with Nonculprit Plaque Instability in Patients with Acute Coronary Syndromes: A 3-Vessel Optical Coherence Tomography Study In vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction: a clinical, angiographical, and intravascular optical coherence tomography study Correlation of retinal sensitivity in microperimetry with vascular density in optical coherence tomography angiography in primary open-angle glaucoma Normal Reference Ranges of Optical Coherence Tomography Parameters in Children Optical coherence tomography angiography using the black-and-white pixel binarization histogram software: a new technique for evaluating healing of macular holes in two surgical techniques B-Scan Attentive CNN for the Classification of Retinal Optical Coherence Tomography Volumes