1. Articles from Mengyang Liu

    1-18 of 18
    1. PhD student position available at the Leitgeb/Drexler Group at the Medical University of Vienna

      PhD student position available at the Leitgeb/Drexler Group at the Medical University of Vienna

      A PhD student position funded by the EU project SWIMMOT is now available in the Leitgeb/Drexler Group at the Medical University of Vienna. The junior and senior supervisors for this position are Dr. Mengyang Liu and Prof. Wolfgang Drexler, respectively. As an international collaborative project, SWIMMOT aims to use multimodal imaging systems to visualize contrast agent labeled tissues in zebrafish. The team of Prof. Beatriz Pelaz at Universidade de Santiago de Compostela, Dr. Stefan Schrittwieser at Austrian Institute of Technology, and Dr. Katerina Soulantica at Institut National des Sciences Appliquees Toulouse will develop biofunctionalized contrast agents. The team of ...

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    2. Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

      Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

      Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance. Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis. Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results: The most disruptive future OCT innovations include imaging resolution and speed (single-beam ...

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    3. REAP: Revealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography

      REAP: Revealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography

      Despite chemotherapy, residual tumors often rely on so-called drug tolerant persister (DTP) cells, which evade treatment to give rise to therapy-resistant relapse and refractory disease. Detection of residual tumor cells proves to be challenging because of the rarity and heterogeneity of DTP cells. In the framework of a H2020 project, REAP will gather researchers and engineers from six countries, who will combine their expertise in biology, chemistry, oncology, material sciences, photonics, and electrical and biomedical engineering in the hope of revealing DTPs in cancer using contrast enhanced multimodal optical imaging. Laser sources for photoacoustic microscopy (PAM), photoacoustic tomography (PAT), and ...

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    4. Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

      Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

      Objective: 3D optical coherence tomography (OCT) is used for analyses of human placenta organoids in situ without sample preparation. Methods: The trophoblast organoids analyzed were derived from primary human trophoblast. In this study a custom made ultra-high-resolution spectral domain OCT system with uniform spatial and axial resolution of 2.48 m in organoid tissue was used. The obtained OCT results align to differentiation status tested via quantitative polymerase chain reaction, Western blot analyses, immunohistochemistry, and immunofluorescence of histological sections. Results: 3D OCT enables a more detailed placenta organoid monitoring compared to brightfield microscopy. Inner architecture with light scattering bridges surrounding ...

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    5. Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source

      Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source

      We analyze the influence of intrinsic polarization alignment on image quality and axial resolution employing a broadband 840 nm light source with an optical bandwidth of 160 nm and an output power of 12 mW tailored for spectral-domain optical coherence microscopy (SD-OCM) applications. Three superluminescent diodes (SLEDs) are integrated into a 14-pin butterfly module using a free-space micro-optical bench architecture, maintaining a constant polarization state across the full spectral output. We demonstrate superior imaging performance in comparison to traditionally coupled-SLED broadband light sources in a teleost model organism in-vivo .

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    6. Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae

      Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae

      We present a dual modality functional optical coherence tomography and photoacoustic microscopy (OCT-PAM) system. The photoacoustic modality employs an akinetic optical sensor with a large imaging window. This imaging window enables direct reflection mode operation, and a seamless integration of optical coherence tomography (OCT) as a second imaging modality. Functional extensions to the OCT-PAM system include Doppler OCT (DOCT) and spectroscopic PAM (sPAM). This functional and non-invasive imaging system is applied to image zebrafish larvae, demonstrating its capability to extract both morphological and hemodynamic parameters in vivo in small animals, which are essential and critical in preclinical imaging for physiological ...

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    7. Optical coherence tomography angiography and photoacoustic imaging in dermatology

      Optical coherence tomography angiography and photoacoustic imaging in dermatology

      Optical coherence tomography angiography (OCTA) is a relatively novel functional extension of the widely accepted ophthalmic imaging tool named optical coherence tomography (OCT). Since OCTA’s debut in ophthalmology, researchers have also been trying to expand its translational application into dermatology. The ability of OCTA in resolving microvasculature has shown promising results in imaging skin diseases. Meanwhile, photoacoustic imaging (PAI), which uses laser pulse induced ultrasound waves as the signal, has been studied to differentiate human skin layers and to help skin disease diagnosis. This perspective article gives a short review of OCTA and PAI in the field of photodermatology ...

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    8. PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna

      PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna

      A funded PhD student position at the Drexler Lab is open for application immediately. Enrollment is on a rolling basis. The project for this position is multimodal imaging combining optical coherence microscopy and photoacoustic microscopy for preclinical small animal imaging. Both endogenous and exogenous contrast agents should be used to explore molecular contrast. The addition of spectroscopic photoacoustic imaging and functional optical coherence microscopy gives access to the metabolism of the small animal model, e.g. zebrafish embryos and chicken embryos. After learning the operation procedure of the current system, we’d expect the student to perform a range of ...

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    9. Post Doc Position for retinal imaging using adaptive optics technology at the Medical University Vienna

      Post Doc Position for retinal imaging using adaptive optics technology at the Medical University Vienna

      A PostDoc position will be available from April 1, 2018 at the Center for Medical Physics and Biomedical Engineering , Medical University of Vienna. The candidate will work within the framework of a SFB (“Spezialforschungsbereich”) of the Austrian Science Fund (FWF) in the field of adaptive optics for retinal imaging. The project duration will be four years with the option of an extension, in the case of a successful project, of additional four years. The annual income of the position for full time employment will be ~50kEuros. The successful candidate has a PhD in, physics, engineering sciences, biomedical engineering or equivalent ...

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    10. PhD student position in quantitative multimodal optical imaging at the Drexler Lab

      PhD student position in quantitative multimodal optical imaging at the Drexler Lab

      One funded PhD student position at the Drexler Lab is open for application immediately. Enrollment is on a rolling basis. The project for this position is quantitative imaging using a combined optical coherence and photoacoustic tomography system. Please check our website (link given in the end) for a list of publications of our group in this topic, so you know the status of our research in this field. After learning the operation procedure of the current system, we’d expect the position taker to perform a range of experiments involving both patients and phantoms. At the same time, the system ...

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    11. Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients’ bodies, we applied our multimodality imaging system to investigate several different types of skin conditions. Quantitative vascular analysis is given for each of the dermatological conditions to show the potential ...

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    12. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin ...

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    13. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable to provide. Co-registered volumes for vessel network is further embedded in the morphologic image provided by OCT. This multi-modal system is therefore demonstrated as a valuable tool for comprehensive non-invasive ...

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    14. In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      Vascular abnormalities serve as a key indicator for many skin diseases. Currently available methods in dermatology such as histopathology and dermatoscopy analyze underlying vasculature in human skin but are either invasive, time-consuming, and laborious or incapable of providing 3D images. In this work, we applied for the first time dual-modality photoacoustic and optical coherence tomography that provides complementary information about tissue morphology and vasculature of patients with different types of dermatitis. Its noninvasiveness and relatively short imaging time and the wide range of diseases that it can detect prove the merits of the dual-modality imaging system and show the great ...

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    15. Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Chick embryos are an important animal model for biomedical studies. The visualization of chick embryos, however, is limited mostly to postmortem sectional imaging methods. In this work, we present a dual modality optical imaging system that combines swept-source optical coherence tomography and whole-body photoacoustic tomography, and apply it to image chick embryos at three different development stages. The explanted chick embryos were imaged in toto with complementary contrast from both optical scattering and optical absorption. The results serve as a prelude to the use of the dual modality system in longitudinal whole-body monitoring of chick embryos in ovo .

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    16. Optical coherence tomography today: speed, contrast, and multimodality

      Optical coherence tomography today: speed, contrast, and multimodality

      In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and ...

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    17. A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications (Thesis)

      A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications (Thesis)
      Optical coherence tomography (OCT) has been widely used in biomedical imaging ever since its introduction. However, the application of OCT for biometrics is relatively new. This thesis demonstrates the feasibility of applying a spectral domain optical coherence tomography (SD-OCT) system to fingertip biometric information retrieval. The results show that SD-OCT is capable of retrieving Level 3 fingertip information. Combined with traditional Level 1 and 2 fingerprint information, which can also be easily acquired by SD-OCT, the proposed application shows potential for ultra-secure scenarios. Photoacoustic microscopy (PAM) is another imaging modality gaining considerable interest in the past decade. Different than OCT ...
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    18. Biometric Mapping of Fingertip Eccrine Glands With Optical Coherence Tomography

      Biometric Mapping of Fingertip Eccrine Glands With Optical Coherence Tomography
      Biometric access control systems often employ fingerprint recognition based on the analysis of ridge patterns and minutiae. The inclusion of finer details, such as sweat pores, increases the accuracy of fingerprint identification. However, the distribution of sweat pores is difficult to extract from conventional fingerprint images, where image quality is susceptible to variations in fingertip surface conditions. Furthermore, a fingertip surface can be routinely counterfeited with a variety of techniques. We propose a more reliable biometric technology using spectral domain optical coherence tomography (SD-OCT) to image the subsurface of a fingertip. Experiments demonstrate high repeatability in clearly visualizing the distribution ...
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    1-18 of 18
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    1. (15 articles) Medical University of Vienna
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    Biometric Mapping of Fingertip Eccrine Glands With Optical Coherence Tomography A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications (Thesis) Optical coherence tomography today: speed, contrast, and multimodality In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography PhD student position in quantitative multimodal optical imaging at the Drexler Lab Post Doc Position for retinal imaging using adaptive optics technology at the Medical University Vienna PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna PhD student position available at the Leitgeb/Drexler Group at the Medical University of Vienna The truth about invisible posterior vitreous structures Increased Macrophage-like Cell Density in Retinal Vein Occlusion as Characterized by en Face Optical Coherence Tomography