1. Articles from Nathan Doble

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    1. PhD Studentship in High Resolution Retinal Imaging The Ohio State University

      PhD Studentship in High Resolution Retinal Imaging The Ohio State University

      A NIH funded PhD studentship is available in the laboratory of Drs. Nathan Doble and Stacey Choi in the College of Optometry/Department of Ophthalmology and Visual Science at The Ohio State University (OSU). The successful candidate will enroll in the PhD program in Vision Science at The Ohio State University and conduct their dissertation work within a highly collaborative research environment focused on the development and use of novel high-resolution optical instrumentation for the study of retinal structure and function. The candidate will be expected to assist with construction and validation of novel instrumentation as well as the collection ...

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    2. Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University

      Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University

      A NIH funded Post Doctoral Scholar position is available in the laboratory of Drs. Nathan Doble and Stacey Choi in the College of Optometry/Department of Ophthalmology and Visual Science at The Ohio State University (OSU). The successful candidate will work within a highly collaborative research environment focused on the development and use of novel high-resolution optical instrumentation for the study of retinal structure and function. The candidate will be expected to assist with construction and validation of novel instrumentation as well as the collection and analysis of the experimental data; preparation of research results for publication and talks; writing ...

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    3. Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury

      Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury

      Purpose: To examine the three-dimensional foveal cone photoreceptor structure in a patient who had suffered laser pointer induced retinal injury . Methods: Patient underwent standard fundus photography and clinical spectral domain optical coherence tomography (SD-OCT) imaging. High-resolution imaging was performed using an Adaptive Optics -OCT-Scanning Laser Ophthalmoscope (AO-OCT-SLO). Results: AO imaging revealed loss of inner and outer segments of cone photoreceptors while the anterior retinal layers appeared healthy. Analysis of cone topology showed an increase in Voronoi domain area and a less regular hexagonal packing structure closer to the lesion site. Conclusion: Exposure to laser pointer radiation, however brief, can result ...

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    4. Inner Retinal Changes in Primary Open-Angle Glaucoma Revealed Through Adaptive Optics-Optical Coherence Tomography

      Inner Retinal Changes in Primary Open-Angle Glaucoma Revealed Through Adaptive Optics-Optical Coherence Tomography

      Purpose: To examine the microstructural changes in the inner nuclear layer (INL) and ganglion cell layer (GCL) in a primary open-angle glaucoma (POAG) subject at 2 timepoints, 4 months apart. Patients and Methods: This case-control study (1 POAG subject and 1 normal control) used the single cell, 3-dimensional volumetric imaging capability of an adaptive optics - optical coherence tomography -scanning laser ophthalmoscopy system to examine the inner retina. Results: At the area of greatest glaucomatous change in the POAG subject [3-degrees temporal (T), 3-degrees inferior (I), right eye], the GCL was greatly thinned at both timepoints, yet retinal ganglion cell soma ...

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    5. Inner Retinal Changes in Primary Open Angle Glaucoma Revealed through Adaptive Optics Optical Coherence Tomography

      Inner Retinal Changes in Primary Open Angle Glaucoma Revealed through Adaptive Optics Optical Coherence Tomography

      Purpose: To examine the microstructural changes in the inner nuclear layer (INL) and ganglion cell layer (GCL) in a primary open angle glaucoma (POAG) patient at 2 time points, 4 months apart. Patients and Methods: This case-control study (one POAG patient and one normal control) used the single cell, three-dimensional volumetric imaging capability of an adaptive optics - optical coherence tomography -scanning laser ophthalmoscopy system to examine the inner retina. Results: At the area of greatest glaucomatous change in the POAG patient (3°T-3°I, right eye), the GCL was greatly thinned at both time points, yet retinal ganglion cell (RGC ...

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    6. Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope

      Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope

      We have designed and implemented a dual-mode adaptive optics (AO) imaging system that combines spectral domain optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) for in vivo imaging of the human retina. The system simultaneously acquires SLO frames and OCT B-scans at 60 Hz with an OCT volume acquisition time of 4.2 s. Transverse eye motion measured from the SLO is used to register the OCT B-scans to generate three-dimensional (3-D) volumes. Key optical design considerations include: minimizing system aberrations through the use of off-axis relay telescopes, conjugate pupil plane requirements, and the use of dichroic beam splitters ...

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    7. Performance of a combined optical coherence tomography and scanning laser ophthalmoscope with adaptive optics for human retinal imaging application

      Performance of a combined optical coherence tomography and scanning laser ophthalmoscope with adaptive optics for human retinal imaging application

      We describe the design and performance of a recently implemented retinal imaging system for the human eye that combines adaptive optics (AO) with spectral domain optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO). The AO-OCT-SLO system simultaneously acquires SLO frames and OCT B-scans at 60 Hz with an OCT volume acquisition scan rate of 0.24 Hz. The SLO images are used to correct for eye motion during the registration of OCT B-scans. Key optical design considerations are discussed including: minimizing system aberrations through the use of off-axis relay telescopes; choice of telescope magnification based on pupil plane requirements ...

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    8. Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging

      Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging
      Aims It is well established that glaucoma results in a thinning of the inner retina. To investigate whether the outer retina is also involved, ultrahigh-resolution retinal imaging techniques were utilised. Methods Eyes from 10 glaucoma patients (25–78 years old), were imaged using three research-grade instruments: (1) ultrahigh-resolution Fourier-domain optical coherence tomography (UHR-FD-OCT), (2) adaptive optics (AO) UHR-FD-OCT and (3) AO-flood illuminated fundus camera (AO-FC). UHR-FD-OCT and AO-UHR-FD-OCT B-scans were examined for any abnormalities in the retinal layers. On some patients, cone density measurements were made from the AO-FC en face images. Correlations between retinal structure and visual sensitivity were ...
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      Mentions: UC Davis
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    1. (6 articles) The Ohio State University
    2. (4 articles) UC Davis
    3. (2 articles) National Institutes of Health
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    5. (1 articles) Massachusetts General Hospital
    6. (1 articles) Harvard University
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    Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging Performance of a combined optical coherence tomography and scanning laser ophthalmoscope with adaptive optics for human retinal imaging application Volumetric imaging of rod and cone photoreceptor structure with a combined adaptive optics-optical coherence tomography-scanning laser ophthalmoscope Inner Retinal Changes in Primary Open Angle Glaucoma Revealed through Adaptive Optics Optical Coherence Tomography Inner Retinal Changes in Primary Open-Angle Glaucoma Revealed Through Adaptive Optics-Optical Coherence Tomography Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University PhD Studentship in High Resolution Retinal Imaging The Ohio State University Stevens Institute of Technology Receives NIH Grant for Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy Minimally Invasive Polarization Sensitive Optical Coherence Tomography (PS-OCT) for assessing Pre-OA, a pilot study on technical feasibility Repeatability and Reproducibility of 4.5 by 4.5 mm Peripapillary Optical Coherence Tomography Angiography Scans in Glaucoma and Non-Glaucoma Eyes Insights into the developing fovea revealed by imaging