1. Articles from Florence Coscas

    1-24 of 30 1 2 »
    1. Quantitative Optical Coherence Tomography Angiography Biomarkers in a Treat-and-Extend Dosing Regimen in Neovascular Age-Related Macular Degeneration

      Quantitative Optical Coherence Tomography Angiography Biomarkers in a Treat-and-Extend Dosing Regimen in Neovascular Age-Related Macular Degeneration

      Purpose : To evaluate the association between quantitative optical coherence tomography angiography (OCT-A) parameters and clinical outcomes in treatment-naïve neovascular age-related macular degeneration (nAMD) patients treated with a treat-and-extend dosing regimen on a 12-month follow-up interval. Methods : Observational, prospective study of consecutive patients. The treatment protocol was based on a loading dose of three anti-vascular endothelial growth factor (VEGF) intravitreal injections (IVI) followed by a treat-and-extend regimen. Eyes were evaluated by swept-source OCT-A at baseline, 1 month after the loading dose and at 12 months. A quantitative analysis was issued for fractal dimension (FD), lacunarity index (LAC), blood flow surface ...

      Read Full Article
    2. Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

      Biomarkers of Peripheral Nonperfusion in Retinal Venous Occlusions Using Optical Coherence Tomography Angiography

      Purpose : To study the association between the assessment of central macular vascular layers by optical coherence tomography angiography (OCT-A) and peripheral nonperfusion evaluated by fluorescein angiography (FA) in patients with retinal venous occlusion (RVO). Methods : Retrospective review of RVO patients without macular edema. Patients underwent a comprehensive ophthalmic examination including FA, spectral-domain OCT, and OCT-A. Significant ischemia was defined as nonperfusion areas superior or equal to the equivalent of one retinal quadrant on FA. Vascular density (VD) and foveal avascular zone were measured using AngioAnalytics software. Fractal dimension (FD) and lacunarity (LAC) were computed using an algorithm designed by MATLAB ...

      Read Full Article
    3. Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions

      Optical coherence tomography angiography in exudative age-related macular degeneration: a predictive model for treatment decisions

      Aims To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity. Methods Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. These findings were then correlated with those of structural OCT scans. A ...

      Read Full Article
    4. Quantitative optical coherence tomography angiography biomarkers for neovascular age-related macular degeneration in remission

      Quantitative optical coherence tomography angiography biomarkers for neovascular age-related macular degeneration in remission

      Purpose To characterize quantitative optical coherence tomography angiography (OCT-A) parameters in active neovascular age-related macular degeneration (nAMD) patients under treatment and remission nAMD patients. Design Retrospective, cross-sectional study. Participants One hundred and four patients of whom 72 were in Group 1 (active nAMD) and 32 in Group 2 (remission nAMD) based on SD-OCT (Spectral Domain OCT) qualitative morphology. Methods This study was conducted at the Centre Ophtalmologique de l’Odeon between June 2016 and December 2017. Eyes were analyzed using SD-OCT and high-speed (100 000 A-scans/second) 1050-nm wavelength swept-source OCT-A. Speckle noise removal and choroidal neovascularization (CNV) blood flow ...

      Read Full Article
    5. Optical coherence tomography angiography in age-related macular degeneration: The game changer

      Optical coherence tomography angiography in age-related macular degeneration: The game changer

      Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch’s membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions. Optical coherence tomography angiograms, due to the longer wavelength used by optical ...

      Read Full Article
    6. Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography

      Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography

      To compare the optical coherence tomography angiography (OCT-A) findings of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in eyes with pseudophakic cystoid macular edema (PCME) with those of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) and to compare PCME vascular density values of the SCP and DCP with those of healthy eyes. In this retrospective observational study, 13 eyes (12 patients) with PCME underwent comprehensive ophthalmologic examinations including visual acuity, FA, SD-OCT, and OCT-A. The vascular density of the SCP and DCP were measured using AngioAnalytics software in all PCME eyes and compared with 46 ...

      Read Full Article
    7. Early detection of radiation maculopathy using OCTA imaging: a case report

      Early detection of radiation maculopathy using OCTA imaging: a case report

      Objective To report the case of a 62-year-old female treated with proton beam radiotherapy for a choroidal melanoma. Results After irradiation, the patient was followed-up regularly. Although clinical examination and spectral domain optical coherence tomography (OCT) showed no signs of radiation maculopathy, OCT angiography (OCTA) enabled detection of abnormalities (rarefaction of the vessel at both retinal capillary plexuses) probably related to the radiation maculopathy. Conclusion OCTA could help in the early detection of radiation maculopathy. This could be an important tool to monitor patients and discuss earlier treatments.

      Read Full Article
    8. Optical Coherence Tomography-Angiography of Macular Features after Proton Beam Radiotherapy for Small Choroidal Melanoma

      Optical Coherence Tomography-Angiography of Macular Features after Proton Beam Radiotherapy for Small Choroidal Melanoma

      Purpose To describe the macular features of patients treated with proton beam therapy for choroidal melanoma (CM), using the optical coherence tomography-angiography (OCTA). Design Retrospective case-control study. Methods This study included patients treated with proton beam radiotherapy (PBR) for a small CM. Only patients that had received 100% of the dose 60 GyEBR to the macular area were included in the analysis. All the patients have undergone a full ophthalmological examination including: visual acuity, OCT B-scan and OCTA. Qualitative and quantitative vascular features of the retinal plexus and the choriocapillaris were analyzed on OCTA and compared to healthy subjects matched ...

      Read Full Article
    9. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL VEIN OCCLUSION: Correlations Between Macular Vascular Density, Visual Acuity, and Peripheral Nonperfusion Area on Fluorescein Angiography

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN RETINAL VEIN OCCLUSION: Correlations Between Macular Vascular Density, Visual Acuity, and Peripheral Nonperfusion Area on Fluorescein Angiography

      Purpose: To study correlations in patients with retinal vein occlusion between the automatically quantified macular vascular densities in the superficial and deep capillary plexus (DCP) obtained using optical coherence tomography angiography (OCTA) and the data from conventional examination, particularly visual acuity and peripheral retinal nonperfusion assessed using fluorescein angiography (FA). Methods: Retrospective, observational study of patients with retinal vein occlusion who underwent a comprehensive ophthalmic examination including FA and OCTA using the AngioVue OCTA system version 2015.100.0.35 (OptovueRTVue XR 100; AVANTI, Inc, Fremont, CA). Vascular densities in the superficial capillary plexus and DCP, as well as the ...

      Read Full Article
    10. Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Purpose: To evaluate changes of vascular flow of patients treated with intravitreal injections of anti-vascular endothelial growth factor for macular edema secondary to retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA). Methods: Patients with RVO with macular edema and treated with intravitreal injections of anti-vascular endothelial growth factors were retrospectively evaluated. The following examinations were performed before and after treatment: best-corrected visual acuity, spectral domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc). Automatic measurement of vascular density of the superficial and deep capillary plexus was also performed and compared with age- and sex-matched healthy subjects. Results ...

      Read Full Article
    11. Choroidal neovascularization in Malattia Leventinese diagnosed using Optical Coherence Tomography Angiography

      Choroidal neovascularization in Malattia Leventinese diagnosed using Optical Coherence Tomography Angiography

      Purpose To compare Optical Coherence Tomography Angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese Design Retrospective case series. Methods Eight eyes of four consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmological examination including color fundus photography, fluorescein and indocyanine green angiographies, Spectral Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography. Results The choriocapillaris segmentation of OCT-A revealed the presence of a hyperflow signal corresponding to active choroidal neovascularization in 3 eyes and inactive choroidal neovascularization in one eye. Traditional multimodal imaging did not show each vascular layer and any leakage ...

      Read Full Article
    12. QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF: Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      QUALITATIVE AND QUANTITATIVE FOLLOW-UP USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VEIN OCCLUSION TREATED WITH ANTI-VEGF: Optical Coherence Tomography Angiography Follow-up of Retinal Vein Occlusion

      Purpose: To evaluate changes of vascular flow of patients treated with intravitreal injections of anti-vascular endothelial growth factor for macular edema secondary to retinal vein occlusion (RVO) with optical coherence tomography angiography (OCTA). Methods: Patients with RVO with macular edema and treated with intravitreal injections of anti-vascular endothelial growth factors were retrospectively evaluated. The following examinations were performed before and after treatment: best-corrected visual acuity, spectral domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc). Automatic measurement of vascular density of the superficial and deep capillary plexus was also performed and compared with age- and sex-matched healthy subjects. Results ...

      Read Full Article
    13. Optical coherence tomography angiography in retinal vein occlusion treated with dexamethasone implant: a new test for follow-up evaluation

      Optical coherence tomography angiography in retinal vein occlusion treated with dexamethasone implant: a new test for follow-up evaluation

      To quantitatively and qualitatively analyze patients with macular edema secondary to retinal vein occlusion (RVO) and treated with the intravitreal dexamethasone implant using optical coherence tomography angiography (OCTA). The files of patients treated with intravitreal injection of dexamethasone implant for macular edema secondary to RVO were retrospectively analyzed. Before and after injection, the following data were recorded: best-corrected visual acuity (BCVA), central macular thickness (CMT) measured using spectral-domain optical coherence tomography, fluorescein angiography, and OCTA (Optovue, Inc., Fremont, CA, USA). Results of automatic measurement of vascular density of the superficial capillary plexus (SCP) and deep capillary plexus were obtained before ...

      Read Full Article
    14. Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography

      Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography

      Purpose : To establish a normative database for vascular density (VD) and foveal avascular zone (FAZ) at the superficial (SCP) and deep capillary plexus (DCP) in healthy subjects with optical coherence tomography (OCT) angiography. Methods : The study was a retrospective chart review of healthy patients who had undergone OCT angiography imaging. A 3- × 3-mm area, centered on the fovea, was scanned for all the study eyes. The automated segmentation allowed separate analysis of the SCP, the DCP, and a comprehensive C-scan including both vascular layers. On the obtained images, VD and FAZ measurements were computed. Interobserver reproducibility and intraobserver repeatability were ...

      Read Full Article
    15. Automated Quantitative Analysis of Retinal Microvasculature In Normal Eyes On Optical Coherence Tomography Angiography

      Automated Quantitative Analysis of Retinal Microvasculature In Normal Eyes On Optical Coherence Tomography Angiography

      Purpose To describe a new automated quantitative technique for displaying and analyzing macular vascular perfusion using optical coherence tomography angiography (OCT-A) and to determine a normative data set, which might be used as reference in identifying progressive changes due to different retinal vascular diseases. Design Reliability study. Methods A retrospective review of forty-seven eyes of 47 consecutive healthy subjects imaged with a spectral domain OCT-A device was performed in a single institution. Full-spectrum amplitude-decorrelation angiography generated OCT-angiograms of the retinal superficial and deep capillary plexuses. A fully-automated custom built software was used to provide quantitative data on the foveal avascular ...

      Read Full Article
    16. Optical Coherence Tomography Angiography of a Choroidal Neovascularization in Adult Onset Foveomacular Vitelliform Dystrophy: Pearls and Pitfalls

      Optical Coherence Tomography Angiography of a Choroidal Neovascularization in Adult Onset Foveomacular Vitelliform Dystrophy: Pearls and Pitfalls

      Purpose : The purpose of this study was to determine the sensitivity and specificity of optical coherence tomography angiography (OCT-A) in detecting choroidal neovascularization (CNV)-complicating adult onset foveomacular vitelliform dystrophy (AOFVD) and to highlight the possible pitfalls related to the heterogeneous spectrum of acquired vitelliform maculopathies. Methods : Twenty-five eyes of 22 consecutive AOFVD patients with suspected CNV were enrolled. Conventional multimodal imaging findings, based on fluorescein angiography (FA), indocyanine green angiography (ICGA) and B-Scan OCT, were used as a basis and were compared with those obtained from OCT-A to define its sensitivity and specificity for detecting CNV in the case ...

      Read Full Article
    17. En face enhanced depth imaging optical coherence tomography of polypoidal choroidal vasculopathy

      En face enhanced depth imaging optical coherence tomography of polypoidal choroidal vasculopathy

      Purpose To analyse retinal and choroidal changes associated with polypoidal choroidal vasculopathy (PCV) using en face spectral-domain optical coherence tomography (SD-OCT). Methods In this retrospective and descriptive study, we collected imaging of patients affected with PCV examined using enhanced depth imaging (EDI) SD-OCT, fluorescein and indocyanine green angiography for a qualitative analysis. The three-dimensional reconstruction of 197 transverse sections with EDI SD-OCT at 30 μm intervals provided a virtual macular brick through which 496 sections in the coronal plane resulted in a C-scan or en face OCT image. Results 30 eyes of 30 patients affected with PCV were studied. En ...

      Read Full Article
    18. Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

      Optical Coherence Tomography Angiography in Retinal Vein Occlusion: Evaluation of Superficial and Deep Capillary Plexa

      Purpose To evaluate the optical coherence tomography angiography(OCT-angiography) appearance of the superficial and deep capillary plexa in eyes with retinal vein occlusion (RVO) and to compare these findings with those of fluorescein angiography(FA) and spectral-domain optical coherence tomography(SD-OCT). Design : Retrospective observational case series. Method Patients presenting with RVO to Creteil University Eye Clinic were retrospectively evaluated. All patients had undergone a comprehensive ophthalmic examination including FA, SD-OCT and OCT-angiography. Results There were 54 (31 male, 57%) RVO patients with a mean age of 70 years. The perifoveal capillary arcade was visible in 52 eyes (96%) on OCT-angiography ...

      Read Full Article
    19. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION: A New Diagnostic Challenge

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION: A New Diagnostic Challenge

      Purpose: To compare optical coherence tomography angiography (OCTA) with traditional multimodal imaging in patients with exudative age-related macular degeneration in terms of guiding the treatment decision. Methods: Prospective case series of 80 eyes of 73 consecutive patients with exudative age-related macular degeneration (39 women, mean age: 79.4 +/- 5.3 years) diagnosed with different types of choroidal neovascularization (CNV) (58 Type I, 2 Type II, 6 mixed Type I and II, 3 retinal angiomatous proliferation, and 11 age-related macular degeneration-related polyps). The data obtained from traditional multimodal imaging, based on fluorescein angiography, indocyanine green angiography, and OCT were used to ...

      Read Full Article
    20. En face enhanced depth imaging optical coherence tomography features in adult onset foveomacular vitelliform dystrophy

      En face enhanced depth imaging optical coherence tomography features in adult onset foveomacular vitelliform dystrophy

      Background Our purpose was to describe the different morphological features in adult onset foveomacular vitelliform dystrophy (AOFVD), using en face enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods Thirty eyes of 22 consecutive patients presenting with diagnosis of AOFVD were enrolled. Diagnosis of AOFVD was concluded based on fundus examination, autofluorescence imaging, fluorescein angiography and SD-OCT. En face OCT imaging was obtained with the Spectralis EDI SD-OCT; 97 inverted sections (nine averaged B-scans per image) were acquired. Results On en face OCT, vitelliform lesions appeared as regular concentric rings of different reflectivity. From the periphery to center of ...

      Read Full Article
    21. SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years

      Purpose: To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). Methods: Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic and autofluorescence images. The analysis of the different steps was obtained initially from the first eye, then successively from the fellow eye when progressive changes appeared. Results: The earliest visible alteration at SD-OCT was the interruption of the interface between inner segment and ellipsoid (IS/EL) (stage 1). The second stage was characterized by the ...

      Read Full Article
    22. Hyperreflective Dots: A New Spectral-Domain Optical Coherence Tomography Entity for Follow-Up and Prognosis in Exudative Age-Related Macular Degeneration

      Hyperreflective Dots: A New Spectral-Domain Optical Coherence Tomography Entity for Follow-Up and Prognosis in Exudative Age-Related Macular Degeneration

      Purpose: Spectral-domain optical coherence tomography (SD-OCT) enables high-resolution analysis of retinal layers and previously unseen hyperreflective dots (HRD). HRD morphological characteristics, evolution, possible origin and prognostic value are discussed. Methods: We conducted a prospective study of 100 patients with exudative age-related macular degeneration (AMD), who were treated and followed up with monthly imaging examinations. Statistical correlations between visual acuity (VA) and pre-/post- treatment HRD characteristics were evaluated. Results: HRD were present in all cases, mainly in the outer retinal layers but also elsewhere. After treatment, HRD regressed in a few days, 1 month (p < 0.04) and 3 months ...

      Read Full Article
    23. Choroid thickness measurement with RTVue optical coherence tomography in emmetropic eyes, mildly myopic eyes, and highly myopic eyes

      Choroid thickness measurement with RTVue optical coherence tomography in emmetropic eyes, mildly myopic eyes, and highly myopic eyes

      Purpose. To evaluate choroid thickness (CT) with RTVue spectral domain optical coherence tomography (SD-OCT) and the effect of age and myopia in eyes without posterior complications. Methods. In this multicenter cross-sectional study, all enrolled patients were over age 18 and divided them in 3 groups based on refraction: emmetropia (+1 D to –1 D), mild myopia (–1 D to –6 D), and high myopia (–6 D to –20 D) groups. Horizontal scans through the fovea were acquired with RTVue OCT (Optovue Inc., Fremont, California, USA). Choroid thickness was measured at 500 µm intervals up to 1,500 µm temporal and ...

      Read Full Article
    1-24 of 30 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (26 articles) Centre Hospitalier Intercommunal de Créteil
    2. (24 articles) Gabriel J. Coscas
    3. (22 articles) Eric H. Souied
    4. (5 articles) San Raffaele Scientfic Institute
    5. (5 articles) Francesco Bandello
    6. (5 articles) Giuseppe Querques
    7. (5 articles) Heidelberg Spectralis
    8. (4 articles) Optovue
    9. (3 articles) Gisèle Soubrane
    10. (3 articles) Nathalie Massamba
  3. Popular Articles

  4. Picture Gallery

    Polypoidal choroidal vasculopathy and macroaneurysm: respective roles of scanning laser ophthalmoscopy-indocyanine green angiography and optical coherence tomography Analysis of progression of reticular pseudodrusen by spectral domain optical coherence tomography Optical coherence tomography in tadalafil-associated retinal toxicity Analysis of Progression of Reticular Pseudodrusen by Spectral Domain–Optical Coherence Tomography Combined Fluorescein Angiography and Spectral-Domain Optical Coherence Tomography Imaging of Classic Choroidal Neovascularization Secondary to Age-Related Macular Degeneration Before and After Intravitreal Ranibizumab Injections En face enhanced depth imaging optical coherence tomography of fibrovascular pigment epithelium detachment Choroid thickness measurement with RTVue optical coherence tomography in emmetropic eyes, mildly myopic eyes, and highly myopic eyes Hyperreflective Dots: A New Spectral-Domain Optical Coherence Tomography Entity for Follow-Up and Prognosis in Exudative Age-Related Macular Degeneration SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years En face enhanced depth imaging optical coherence tomography features in adult onset foveomacular vitelliform dystrophy ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD) Role of visual evoked potentials and optical coherence tomography in the screening for optic pathway gliomas in patients with neurofibromatosis type I