1. Articles from Jonathan Denniss

    1-4 of 4
    1. Enhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysis

      Enhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysis

      Purpose: To introduce and evaluate the performance in detecting glaucomatous abnormalities of a novel method for extracting en face slab images (SMAS), which considers varying individual anatomy and configuration of retinal nerve fiber bundles. Methods: Dense central retinal spectral domain optical coherence tomography scans were acquired in 16 participants with glaucoma and 19 age-similar controls. Slab images were generated by averaging reflectivity over different depths below the inner limiting membrane according to several methods. SMAS considered multiple 16 µm thick slabs from 8 to 116 µm below the inner limiting membrane, whereas 5 alternative methods considered single summary slabs of ...

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    2. Depth-resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

      Depth-resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes

      Purpose: Recent developments in optical coherence tomography (OCT) technology enable direct enface visualisation of retinal nerve fibre bundle (RNFB) loss in glaucoma. However, the optimum depth at which to visualise RNFBs across the retina is unknown. We aimed to evaluate the range of depths and optimum depth at which RNFBs can be visualised across the retina in healthy eyes. Methods: The central ± 25° retina of 10 healthy eyes from 10 people aged 57-75 years (median 68.5 years) were imaged with spectral domain OCT. Slab images of maximum axial resolution (4 μm) containing depth-resolved attenuation coefficients were extracted from 0 ...

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    3. Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure–function map. In this review, the structure–function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, ‘one size fits all’ representation, but in recent years methods for customising structure–function maps to individual eyes have been developed and these are reviewed here. In ...

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    4. Spatial and Spectral Imaging of Retinal Laser Photocoagulation Burns

      Spatial and Spectral Imaging of Retinal Laser Photocoagulation Burns

      Purpose: To correlate in vivo spatial and spectral morphologic changes of short to long-pulse 532-nm Nd:YAG retinal laser lesions using Fourier-domain optical coherence tomography (FD OCT), autofluorescence (AF), fluorescein angiography (FA) and multispectral imaging. Methods: Ten eyes with treatment-naive pre-proliferative or proliferative diabetic retinopathy were studied. A titration grid of laser burns at 20-, 100- and 200-milliseconds was applied to the nasal retina, and laser fluence titrated to produce four grades of laser lesion visibility: sub-visible (SV), barely-visible (BV, light-gray), threshold (TH, gray-white), and supra-threshold (ST, white). The AF, FA, FD-OCT, and multispectral imaging were performed 1-week before laser ...

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    1-4 of 4
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    1. (1 articles) University of Manchester
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    Spatial and Spectral Imaging of Retinal Laser Photocoagulation Burns Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications Depth-resolved variations in visibility of retinal nerve fibre bundles across the retina in enface OCT images of healthy eyes Enhanced Objective Detection of Retinal Nerve Fiber Bundle Defects in Glaucoma With a Novel Method for En Face OCT Slab Image Construction and Analysis New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application Short-sighted woman assumes debilitating headaches mean she needs new glasses but discovers she has multiple sclerosis Shedding light on the impact of microplastics on lentil seedling growth Comparison of radial peripapillary capillary density results of individuals with and without Helicobacter pylori infection Ai, Oct Operate in Tandem to Detect Plaque Erosion in the Heart Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series Mimickers of punctate inner retinal toxoplasmosis on optical coherence tomography Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography