1. Articles from william e. smiddy

    1-10 of 10
    1. Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling

      Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling

      Objective To compare thickness and reflectance of retinal layer findings in patients with idiopathic epiretinal membranes (ERMs), before and after surgery, to normal controls. Design A retrospective study Subjects Patients with ERMs before and after surgery and normal controls. Methods Spectral domain optical coherence tomography (SD-OCT) of eyes with ERMs, before and after surgery, and normal eyes were analyzed for morphologic appearance and using a customized algorithm to measure retinal layer reflectance and thickness. Findings were correlated with visual acuity outcomes. Main Outcome Measure Retinal layer thickness and reflectance Results Thirty-four ERM and 12 normal eyes were identified. Mean preoperative ...

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    2. Noninvasive, High-Resolution Functional Macular Imaging in Subjects With Retinal Vein Occlusion

      Noninvasive, High-Resolution Functional Macular Imaging in Subjects With Retinal Vein Occlusion

      BACKGROUND AND OBJECTIVES: Several imaging modalities have been developed to characterize ischemia inherent in retinal vascular diseases. This study aims to predict the impact and to better establish the mechanisms of visual deterioration. A high-resolution functional imaging device is used, yielding quantitative data for macular blood flow and capillary network features in healthy eyes and in eyes with central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). PATIENTS AND METHODS: This prospective, cross-sectional, comparative case series measured blood flow velocities (BFVs) and noninvasive capillary perfusion maps (nCPMs) in macular vessels in patients with BRVO/CRVO and in healthy ...

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    3. Performance evaluation of automated segmentation software on optical coherence tomography volume data

      Performance evaluation of automated segmentation software on optical coherence tomography volume data

      Over the past two decades a significant number of OCT segmentation approaches have been proposed in the literature. Each methodology has been conceived for and/or evaluated using specific datasets that do not reflect the complexities of the majority of widely available retinal features observed in clinical settings. In addition, there does not exist an appropriate OCT dataset with ground truth that reflects the realities of everyday retinal features observed in clinical settings. While the need for unbiased performance evaluation of automated segmentation algorithms is obvious, the validation process of segmentation algorithms have been usually performed by comparing with manual ...

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    4. Reflectivity and thickness analysis of epiretinal membranes using spectral-domain optical coherence tomography

      Reflectivity and thickness analysis of epiretinal membranes using spectral-domain optical coherence tomography

      AIM : To compare thickness and reflectivity spectral domain optical coherence tomography (SD-OCT) findings in patients with idiopathic epiretinal membranes (ERMs), before and after ERM peeling surgery, with normal controls. METHODS : A retrospective study analyzed SD-OCTs of eyes with ERMs undergoing ERM peeling surgery by one surgeon from 2008 to 2010 and normal control eyes. SD-OCTs were analyzed using a customized algorithm to measure reflectivity and thickness. The relationship between the SD-OCT findings and best corrected visual acuity (BCVA) outcomes was also studied. RESULTS : Thirty-four ERM eyes and 12 normal eyes were identified. Preoperative eyes had high reflectivity and thickness of ...

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    5. Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region

      Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region

      Optical coherence tomography (OCT) is a high speed, high resolution and non-invasive imaging modality that enables the capturing of the 3D structure of the retina. The fast and automatic analysis of 3D volume OCT data is crucial taking into account the increased amount of patient-specific 3D imaging data. In this work, we have developed an automatic algorithm, OCTRIMA 3D (OCT Retinal IMage Analysis 3D), that could segment OCT volume data in the macular region fast and accurately. The proposed method is implemented using the shortest-path based graph search, which detects the retinal boundaries by searching the shortest-path between two end ...

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    6. Fractal-based analysis of optical coherence tomography data to quantify retinal tissue damage

      Fractal-based analysis of optical coherence tomography data to quantify retinal tissue damage

      Background The sensitivity of Optical Coherence Tomography (OCT) images to identify retinal tissue morphology characterized by early neural loss from normal healthy eyes is tested by calculating structural information and fractal dimension. OCT data from 74 healthy eyes and 43 eyes with type 1 diabetes mellitus with mild diabetic retinopathy (MDR) on biomicroscopy was analyzed using a custom-built algorithm (OCTRIMA) to measure locally the intraretinal layer thickness. A power spectrum method was used to calculate the fractal dimension in intraretinal regions of interest identified in the images. ANOVA followed by Newman-Keuls post-hoc analyses were used to test for differences between ...

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    7. Clinical manifestations of optic pit maculopathy as demonstrated by spectral domain optical coherence tomography

      Clinical manifestations of optic pit maculopathy as demonstrated by spectral domain optical coherence tomography

      Purpose: The purpose of this retrospective study was to evaluate the characteristic features, including spectral-domain optical coherence tomography (SD-OCT), clinical course, and outcome of treatment if given for patients with optic disc pit maculopathy. Methods: We investigated a consecutive series of patients with a diagnosis of optic pit maculopathy treated between 2001 and 2012 at the Bascom Palmer Eye Institute. Patients were divided into two main groups, ie, patients who were observed without surgery and patients who received surgical intervention. The main outcome measures were presenting and final visual acuity, and changes in SD-OCT imaging were recorded. Other data including ...

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    8. Morphometric Analysis of Epiretinal Membranes Using Spectral-Domain Optical Coherence Tomography

      Morphometric Analysis of Epiretinal Membranes Using Spectral-Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: To determine whether the volumes of macular layers before and after epiretinal membrane (ERM) peeling as measured by spectral-domain optical coherence tomography (SD-OCT) correlated with best-corrected visual acuity (BCVA) or ERM location. PATIENTS AND METHODS: Thirty-six eyes with idiopathic ERM and 12 control eyes were imaged pre-operatively and postoperatively using SD-OCT. The inner, middle, and outer retinal layers were measured in the temporal and nasal half of the central 1,500 μm of the macula for each of the SD-OCT five raster scans and used to estimate the volumes for each group. RESULTS: The inner layer volumes ...

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    9. Surgical Management of Vitreofoveal Traction Syndrome: Optical Coherence Tomographic Evaluation and Clinical Outcomes

      BACKGROUND AND OBJECTIVE To characterize vitreofoveal traction syndrome and to correlate clinical observations, optical coherence tomography features, and surgical results. PATIENTS AND METHODS A retrospective, consecutive, interventional case series of 36 patients. Clinical and optical coherence tomography features taken from patient charts were compared preoperatively and postoperatively and correlated with visual outcomes. RESULTS Preoperatively, visual acuity ranged from 20/40 to 20/400 and improved more than 2 lines in 50% of eyes. A macular hole developed in 2 eyes. The optical coherence tomography appearance of traction resolved in all eyes; cystic change improved markedly or resolved in 86% of ...
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    10. Myopic Traction Maculopathy: Spectral Domain Optical Coherence Tomographic Imaging and a Hypothesized Mechanism

      A patient with progressive visual loss and macular hole development due to progressive myopic traction maculopathy was studied using spectral domain optical coherence tomography (SD-OCT). A characteristic, deep retinal schisis-like change was clearly demonstrable. Progression to a full-thickness macular hole was documented. Postoperatively, the macular hole was closed, and the visual acuity was restored. SD-OCT imaging allowed better resolution of macular features but requires evaluation of all scan data. The source of progressive inner retinal traction may be the posterior extension of the staphyloma. [Ophthalmic Surg Lasers Imaging 2008;39:S90-S94.]
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    1-10 of 10
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    Morphometric Analysis of Epiretinal Membranes Using Spectral-Domain Optical Coherence Tomography Clinical manifestations of optic pit maculopathy as demonstrated by spectral domain optical coherence tomography Fractal-based analysis of optical coherence tomography data to quantify retinal tissue damage Real-Time Automatic Segmentation of Optical Coherence Tomography Volume Data of the Macular Region Reflectivity and thickness analysis of epiretinal membranes using spectral-domain optical coherence tomography Performance evaluation of automated segmentation software on optical coherence tomography volume data Noninvasive, High-Resolution Functional Macular Imaging in Subjects With Retinal Vein Occlusion Reflectance and thickness analysis of retinal layers in patients with epiretinal membranes using spectral-domain optical coherence tomography before and after vitrectomy with membrane peeling High space-bandwidth in quantitative phase imaging using partially spatially coherent optical coherence microscopy and deep neural network Optical coherence tomography assessment of macrophages accumulation in non-ST-segment elevation acute coronary syndromes Early disability in ambulatory patients with multiple sclerosis: optical coherence tomography versus visual evoked potentials, a comparative study Dueling Deep Q-Network for Unsupervised Inter-frame Eye Movement Correction in Optical Coherence Tomography Volumes