1. Articles from tarek alasil

    1-9 of 9
    1. Characterization of Choroidal Layers in Normal Aging Eyes Using Enface Swept-Source Optical Coherence Tomography

      Characterization of Choroidal Layers in Normal Aging Eyes Using Enface Swept-Source Optical Coherence Tomography

      Purpose To characterize qualitative and quantitative features of the choroid in normal eyes using enface swept-source optical coherence tomography (SS-OCT). Methods Fifty-two eyes of 26 consecutive normal subjects were prospectively recruited to obtain multiple three-dimensional 12x12mm volumetric scans using a long-wavelength high-speed SS-OCT prototype. A motion-correction algorithm merged multiple SS-OCT volumes to improve signal. Retinal pigment epithelium (RPE) was segmented as the reference and enface images were extracted at varying depths every 4.13μm intervals. Systematic analysis of the choroid at different depths was performed to qualitatively assess the morphology of the choroid and quantify the absolute thicknesses as ...

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    2. En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomography

      En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomography

      Objective To define morphological features of polypoidal choroidal vasculopathy (PCV) using en face images from swept source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods Ten eyes from 6 patients with PCV and 10 eyes from 5 age-matched normal subjects. All subjects were prospectively scanned with a prototype SS-OCT system. A motion correction algorithm was applied to correct and merge scans into a single volumetric dataset. En face images were generated at intervals of 4.13 μm (1 pixel) relative to the Bruch's membrane. Results Age ± standard deviation for the PCV group was 62.4 (± 12.1) years ...

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    3. Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report

      Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report

      A 72-year-old man with diabetes was referred to the retina clinic for diabetic retinopathy. Detailed funduscopic examination of the left eye was limited by prominent asteroid hyalosis. Spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) were utilized to examine the vitreous, vitreoretinal interface, and the morphology of the retina. Asteroid hyalosis induced artifacts of the OCT images, which resolved when the appropriate imaging protocols were applied. SS-OCT may show superior diagnostic and preoperative capabilities when compared to SD-OCT in the settings of asteroid hyalosis-induced media opacity.

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    4. Facilitating Glaucoma Diagnosis With Intereye Retinal Nerve Fiber Layer Asymmetry Using Spectral-Domain Optical Coherence Tomography

      Facilitating Glaucoma Diagnosis With Intereye Retinal Nerve Fiber Layer Asymmetry Using Spectral-Domain Optical Coherence Tomography

      Purpose: To test whether increased intereye retinal nerve fiber layer (RNFL) asymmetry may be indicative of glaucoma. To determine the best statistical methods and intereye RNFL cutoffs for differentiating between normal and glaucoma subjects to better alert clinicians to early glaucomatous damage. Methods: Sixty-six primary open-angle glaucoma (OAG) and 40 age-matched normal subjects had both eyes imaged at the Massachusetts Eye and Ear Infirmary with a commercially available spectral-domain optical coherence tomography (OCT) machine. Statistical methodologies were used to find cutoffs that achieved the best sensitivities and specificities for differentiating OAG from normal subjects. Results: Intereye RNFL asymmetry for global ...

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    5. Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions

      Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions

      The application of existing optical coherence tomography (OCT) technology to the pediatric population is limited in both the design specification of the device and its hardware. However, the potential of OCT in the pediatric population has not been fully realized. The authors review the literature, highlighting the currently available spectral-domain OCT technology and summarizing the reported normal pediatric OCT parameters for retinal nerve fiber layer and macular thickness. They also review the pediatric ophthalmological conditions in which OCT has been used and discuss advancements in OCT design and their potential applications to the pediatric population. The use of OCT in ...

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    6. Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

      Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

      Purpose: To determine the effects of age, sex, and race on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by the spectral domain optical coherence tomography (SD-OCT) Spectralis machine (Heidelberg Engineering). Methods: Peripapillary SD-OCT RNFL thickness measurements were determined in normal subjects seen at a university-based clinic. One randomly selected eye per subject was used for analysis in this cross-sectional study. Multiple regression analysis was applied to assess the effects of age, sex, ethnicity, and mean refractive error on peripapillary RNFL thickness. Results are expressed as means+/-SD wherever applicable. Results: The study population consisted ...

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    7. Relationship between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Diabetic Macular Edema

      Relationship between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Diabetic Macular Edema

      Purpose: To investigate the relationship between optical coherence tomography (OCT)-derived measurements of retinal morphology and visual acuity in patients with diabetic macular edema.Design: Retrospective cross-sectional study.Participants: A total of 67 consecutive patients (67 eyes) with diabetic macular edema (DME) who underwent Stratus OCT imaging (Carl Zeiss Meditec, Inc., Dublin, CA).Methods: Best-corrected Snellen visual acuity was recorded for each patient. Raw exported Stratus OCT images for each patient were analyzed using custom software entitled “OCTOR,” which allows the precise positioning of prespecified boundaries on individual B-scans. Thickness, volume, and intensity were calculated for neurosensory retina and subretinal ...

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    8. Evaluation of Optical Coherence Tomography Central Retinal Thickness Parameters for use as Anatomic Outcomes in Clinical Trials for Neovascular Age-Related Macular Degeneration

      Purpose: To investigate the relationship between automated and manually-derived measurements of central retinal thickness from optical coherence tomography (OCT), and to determine the relationship between foveal center point (FCP) and foveal central subfield (FCS), in neovascular age-related macular degeneration (AMD). Methods: Data from 216 patients newly diagnosed with neovascular AMD, who underwent StratusOCT imaging at diagnosis, were collected. Raw StratusOCT images for each patient were analyzed using publicly available custom software entitled "OCTOR", which allows accurate manual grading of OCT B-scans. Manually-derived central retinal thickness measurements were compared to measurements obtained from automated StratusOCT analysis. Manually obtained measurements of FCP ...

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    9. Correlation of Fourier Domain Optical Coherence Tomography Retinal Nerve Fiber Layer Maps With Visual Fields in Nonarteritic Ischemic Optic Neuropathy

      BACKGROUND AND OBJECTIVE To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION). PATIENTS AND METHODS Patients with NAION and control subjects were enrolled in a case–control study. Participants were scanned with a Fourier domain optical coherence tomography (OCT) system. Peripapillary NFL thickness was averaged in hemispheric, quadrant, and octant divisions. Standard achromatic static perimetry was used to assess visual fields. RESULTS The reproducibility of peripapillary NFL parameters was excellent in both the healthy and NAION groups. Eyes in the NAION group showed a significant decrease of peripapillary NFL thickness ...
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    1-9 of 9
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    Relationship between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Diabetic Macular Edema Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography Optical Coherence Tomography in Pediatric Ophthalmology: Current Roles and Future Directions Facilitating Glaucoma Diagnosis With Intereye Retinal Nerve Fiber Layer Asymmetry Using Spectral-Domain Optical Coherence Tomography Spectral-Domain and Swept-Source OCT Imaging of Asteroid Hyalosis: A Case Report En Face Imaging of the Choroid in Polypoidal Choroidal Vasculopathy Using Swept-Source Optical Coherence Tomography Characterization of Choroidal Layers in Normal Aging Eyes Using Enface Swept-Source Optical Coherence Tomography Optical coherence tomography angiography in glaucoma Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva Characterisation of macular superficial vessel density alteration in preclinical ethambutol-induced optic neuropathy using optical coherence tomography angiography Three-dimensional spatial reconstruction of coronary arteries based on fusion of intravascular optical coherence tomography and coronary angiography Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier