1. Articles from John Conrath

    1-3 of 3
    1. Micrometer scale resolution images of human corneal graft using full-field optical coherence tomography (FF-OCT)-link to polarimetric study of scattered field

      Micrometer scale resolution images of human corneal graft using full-field optical coherence tomography (FF-OCT)-link to polarimetric study of scattered field
      The suitability of a corneal graft for transplant surgery is based on different criteria. It may be rejected in particular due to a loss of transparency, directly linked to its scattering properties. Then, these become an important parameter. The aim of this paper is to quantify the influence of the cornea thickness and of the epithelial layer on scattering properties. The origin of scattering is discussed based on polarimetric analysis of scattered field (surface and/or bulk) and on full-field optical coherence tomography imaging (structural information).
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    2. Scattering properties and transparency characterization of human corneal grafts

      Scattering properties and transparency characterization of human corneal grafts
      The cornea is the single human tissue being transparent. This unique property may be explained by the particular structure of the cornea, but the precise role of each of its constituents remains unsolved. On other matter, prior to corneal transplant, graft must be evaluated during a sorting procedure where a technician assesses of its transparency quality. Nevertheless, this criterion remains subjective and qualitative. This study proposes to combine 3D imagery using Full-Field Optical Coherence Tomography jointly with angular resolved scattering measurement to achieve a quantitative transparency characterization of the cornea. The OCT provides micrometric resolution structural information about the cornea ...
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    3. Human graft cornea and laser incisions imaging with micrometer scale resolution full-field optical coherence tomography

      Human graft cornea and laser incisions imaging with micrometer scale resolution full-field optical coherence tomography
      Micrometer scale resolution full-field optical coherence tomography (FF-OCT) is developed for imaging human graft corneas. Three-dimensional (3-D) images with ultrahigh resolution (respectively, 1 and 1.5 µm in the axial and transverse directions), comparable to traditional histological sections, are obtained allowing the visualization of the cells and the precise structure of the different layers that compose the tissue. The sensitivity of our device enables imaging the entire thickness of the cornea, even in edematous corneas more than 800 µm thick. Furthermore, we provide tomographic 3-D images of laser incisions inside the tissue at various depths without slicing the studied corneas ...
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    1-3 of 3
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    1. (1 articles) National Institutes of Health
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