1. Articles from william j. feuer

    1-24 of 33 1 2 »
    1. Diagnosing Persistent Hyper-Transmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration

      Diagnosing Persistent Hyper-Transmission Defects on En Face OCT Imaging of Age-Related Macular Degeneration

      Purpose: A training exercise was performed to study the ability of graders to reliably identify precursor lesions to geographic atrophy (GA), known as persistent choroidal hyper-transmission defects (hyperTDs), using en face optical coherence tomography (OCT) images from eyes with non-exudative age-related macular degeneration (AMD). Design: Intergrader agreement study PARTICIPANTS: Eleven graders participated in this exercise. Methods: Formal training on how to identify persistent hyperTDs on en face OCT images was provided to the graders. Persistent hyperTDs were defined as bright lesions having a greatest linear dimension (GLD) of at least 250 μm. Training consisted of a tutorial session followed by ...

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    2. Interocular asymmetry of choroidal thickness and vascularity index measurements in normal eyes assessed by swept-source optical coherence tomography

      Interocular asymmetry of choroidal thickness and vascularity index measurements in normal eyes assessed by swept-source optical coherence tomography

      Background: To investigate the symmetry of interocular choroidal thickness and vascularity index measurements in normal eyes using swept-source optical coherence tomography (SS-OCT). Cross-sectional and observational study. This study included 244 eyes of 122 normal adults with ages uniformly distributed from 19 to 89 years. Methods: SS-OCT imaging was performed using a scanning pattern of 12×12 mm. Mean choroidal thickness (MCT) and choroidal vascularity index (CVI) measurements in the entire scanning region were obtained using a validated and published automatic method. The correlation and differences (including signed and absolute differences) between bilateral MCT and CVI measurements were analyzed at the ...

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    3. Detecting Glaucoma Progression Using Guided Progression Analysis with Optical Coherence Tomography and Visual Field Assessment in Eyes Classified by International Classification of Disease Severity Codes

      Detecting Glaucoma Progression Using Guided Progression Analysis with Optical Coherence Tomography and Visual Field Assessment in Eyes Classified by International Classification of Disease Severity Codes

      Purpose To compare the detection and rates of progressive retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) loss with spectral domain optical coherence tomography (SDOCT) and visual field (VF) loss using Guided Progression Analysis (GPA, Carl Zeiss Meditec, Dublin, CA) in glaucomatous eyes classified using International Classification of Disease diagnosis codes (ICD). Design Retrospective cohort study. Participants Glaucoma patients with at least 3 years of follow-up and a minimum of 4 SDOCT and 5 reliable VF exams. Methods Glaucoma severity was classified using ICD-10- diagnosis codes. Rates of RNFL, macular GCIPL and VF loss were calculated ...

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    4. Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging

      Choroidal Thickness and Choroidal Vessel Density in Nonexudative Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Imaging

      Purpose : To analyze the relationship between choroidal thickness and the distribution of choroidal blood vessels in eyes with nonexudative AMD. Methods : Eyes with a diagnosis of nonexudative AMD were imaged using a prototype 100-kHz swept-source (SS) optical coherence tomography (OCT) instrument (Carl Zeiss Meditec, Dublin, CA, USA) with a central wavelength of 1050 nm. We used an OCT cube scan pattern consisting of 512 × 512 A-scans over a 12 × 12 mm retinal area. The eyes were partitioned into two groups based on the presence or absence of reticular pseudodrusen (RPD). All scans were segmented using an automated algorithm. In addition ...

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    5. Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

      Purpose The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in eyes with nonexudative age-related macular degeneration (AMD). Design Cross-sectional study. Participants Patients with nonexudative AMD were prospectively enrolled in an SS-OCT imaging study at the Bascom Palmer Eye Institute. Methods On the same day, all participants underwent color, FAF, and IR fundus imaging, as well as imaging with a prototype Zeiss 100 kHz SS-OCT instrument (Carl Zeiss Meditec Inc, Dublin ...

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    6. Drusen Volume as a Predictor of Disease Progression in Patients With Late Age-Related Macular Degeneration in the Fellow Eye

      Drusen Volume as a Predictor of Disease Progression in Patients With Late Age-Related Macular Degeneration in the Fellow Eye

      Purpose : Increasing drusen volume was proposed to be a predictor of disease progression in age-related macular degeneration (AMD). In patients with late AMD in one eye, the fellow eyes without neovascularization are known to be at higher risk of developing exudative AMD. We evaluated the relationship between drusen volume in these fellow eyes and their progression to late AMD. Methods : A retrospective analysis included fellow eyes with drusen associated with nonexudative AMD. All eyes with neovascular AMD were treated with intravitreal ranibizumab, aflibercept, and/or bevacizumab and followed for 2 years. All eyes were scanned with the Cirrus HD-OCT using ...

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    7. Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging

      Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging

      Purpose. To investigate the relationship between drusen areas measured with color fundus images (CFIs) and those with spectral-domain optical coherence tomography (SDOCT). Methods. Forty-two eyes from thirty patients with drusen in the absence of geographic atrophy were recruited to a prospective study. Digital color fundus images and SDOCT images were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both CFIs and SDOCT images. Spectral-domain OCT drusen measurements were obtained using a commercially available proprietary algorithm. Drusen boundaries on ...

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    8. Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Change in Drusen Area Over Time Compared Using Spectral Domain Optical Coherence Tomagraphy and Color Fundus Imaging

      Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...

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    9. Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study

      Frequency of abnormal retinal nerve fibre layer and ganglion cell layer SDOCT scans in healthy eyes and glaucoma suspects in a prospective longitudinal study

      Background/aims To examine the frequency of abnormal retinal nerve fibre layer thickness (RNFLT) and ganglion cell complex (GCC) measurements among healthy and glaucoma suspect and preperimetric glaucoma (GSPPG) eyes in a prospective longitudinal study. Methods Normal and GSPPG eyes with ≥18 months follow-up were included. Spectral-domain optical coherence tomography (SDOCT) was performed annually in normal and biannually in GSPPG eyes. One eye was randomly selected for inclusion. RNFLT and GCC parameters with p>5% were classified as ‘within normal limits (WNL)’ and p<1% were classified as ‘outside normal limits (ONL)’. Results 23 normal and 74 GSPPG eyes were ...

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    10. Progressive Loss of Retinal Ganglion Cell Function Precedes Structural Loss by Several Years in Glaucoma Suspects

      Progressive Loss of Retinal Ganglion Cell Function Precedes Structural Loss by Several Years in Glaucoma Suspects

      Purpose. We determined the time lag between loss of retinal ganglion cell function and retinal nerve fiber layer (RNFL) thickness. Methods. Glaucoma suspects were followed for at least four years. Patients underwent pattern electroretinography (PERG), optical coherence tomography (OCT) of the RNFL, and standard automated perimetry testing at 6-month intervals. Comparisons were made between changes in all testing modalities. To compare PERG and OCT measurements on a normalized scale, we calculated the dynamic range of PERG amplitude and RNFL thickness. The time lag between function and structure was defined as the difference in time-to-criterion loss between PERG amplitude and RNFL ...

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    11. Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image

      Comparison of Geographic Atrophy Measurements from the OCT Fundus Image and the Sub-RPE Slab Image

      PURPOSE: To compare two different approaches to measuring areas of geographic atrophy (GA) using spectral-domain optical coherence tomography (SD-OCT). METHODS: Fifty eyes with GA were imaged with an SD-OCT instrument. OCT fundus images and sub– retinal pigment epithelium (RPE) slab images were generated. Three graders manually drew the GA boundaries on both en face images. An automated algorithm was used to segment the GA boundaries from the sub-RPE slabs. RESULTS: The agreement between the three manual measurements on both OCT fundus images (ICC = .998) and sub-RPE slabs (ICC = .999) was excellent. Area measurements from OCT fundus images and sub-RPE slabs ...

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    12. Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Comparison of Dresen Area Detected by Spectral Domain Optical Coherence Tomography and Color Fundus Imaging

      Purpose: To compare the measurements of drusen area from manual segmentation of color fundus photographs with those generated by an automated algorithm designed to detect elevations of the retinal pigment epithelium (RPE) on spectral domain optical coherence tomography (SDOCT) images. Methods: Fifty eyes with drusen secondary to non-exudative age-related macular degeneration (AMD) were enrolled. All eyes were imaged with the Cirrus HD-OCT instrument (Carl Zeiss Meditec, Dublin, CA) using a 200x200 A-scan raster pattern covering a 6mm X 6mm area centered on the fovea. Digital color fundus images were taken on the same day. Drusen were traced manually on the ...

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    13. Identifying the boundaries of retinal pigment epithelial detachments using two spectral-domain optical coherence tomography instruments

      Identifying the boundaries of retinal pigment epithelial detachments using two spectral-domain optical coherence tomography instruments

      BACKGROUND AND OBJECTIVE: To compare two spectral-domain optical coherence tomography (SD-OCT) instruments in identifying the boundaries of retinal pigment epithelium detachment (PED). PATIENTS AND METHODS: 27 eyes were scanned with Cirrus and Spectralis SD-OCT instruments during a single visit. Two Cirrus scan patterns were used: the 512 × 128 and 200 × 200 covering a 6 × 6 mm (20° × 20°) area. The Spectralis scan pattern consisted of seven B-scans, averaged 51 times, covering a 30° × 5° area. The main outcome measures were the retinal thickness at the foveal center and the number of segmentation failures on the central B-scan. RESULTS: The Spectralis ...

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    14. Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT [Clinical Sciences]

      Effect of Race, Age, and Axial Length on Optic Nerve Head Parameters and Retinal Nerve Fiber Layer Thickness Measured by Cirrus HD-OCT [Clinical Sciences]

      Objective To determine the effect of race, demographic, and ocular variables on optic nerve head and retinal nerve fiber layer (RNFL) thickness measurements using spectral-domain optical coherence tomography. Methods In a cross-sectional observational study, 284 normal subjects aged 18 to 84 years were evaluated at 7 sites using Cirrus HD-OCT. Disc area, rim area, average cup-disc ratio, vertical cup-disc ratio, cup volume, and average, temporal, superior, nasal, and inferior RNFL thicknesses were calculated. The main outcome measures were associations between Cirrus HD-OCT optic nerve head and RNFL measurements and age, sex, and race. Results The 284 subjects self-identified as being ...

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    15. Quantitative Imaging of Retinal Pigment Epithelial Detachments Using Spectral-Domain Optical Coherence Tomography

      Quantitative Imaging of Retinal Pigment Epithelial Detachments Using Spectral-Domain Optical Coherence Tomography

      Purpose To evaluate the reproducibility of area and volume measurements of retinal pigment epithelium detachments (PEDs) in eyes of patients with age-related macular degeneration using spectral-domain optical coherence tomography imaging and a novel automated, quantitative algorithm. Design Prospective study to evaluate a diagnostic technology. Methods Patients with PEDs associated with age-related macular degeneration underwent spectral-domain optical coherence tomography imaging. Each eye was imaged 5 times, and each scan consisted of a raster pattern comprising 40 000 uniformly spaced A-scans organized as a 200 × 200 A-scan array. Each raster scan covered a retinal area of 6 × 6 mm encompassing the entire ...

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    16. Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma

      Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in Glaucoma
      Purpose. To demonstrate the capability of SD-OCT to measure macular retinal ganglion cell–inner plexiform layer (GCIPL) thickness and to assess its reproducibility in glaucomatous eyes. Methods. Fifty-one glaucomatous eyes (26 mild, 11 moderate, 14 severe) of 51 patients underwent macular scanning using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) macula 200×200 acquisition protocol. Five scans were obtained on 5 days within 2 months. The ganglion cell analysis (GCA) algorithm was used to detect the macular GCIPL and to measure the thickness of the overall average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL. The reproducibility of ...
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    17. Macular Ganglion Cell-Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral-Domain Optical Coherence Tomography in Glaucoma

      Macular Ganglion Cell-Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral-Domain Optical Coherence Tomography in Glaucoma
      Purpose. To demonstrate the capability of spectral domain OCT to measure the macular retinal ganglion cell layer-inner plexiform layer (GCIPL) thickness, and to assess its reproducibility in glaucomatous eyes. Methods. Fifty-one glaucomatous eyes (26 mild, 11 moderate and 14 severe) of 51 patients underwent macular scanning using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) Macular Cube 200x200 acquisition protocol. Five scans were obtained on five different days within two months. The Cirrus OCT ganglion cell analysis (GCA) algorithm was used to detect the macular GCIPL and measure the thickness of the overall average, minimum, superotemporal, superior, superonasal, inferonasal, inferior ...
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    18. Effects of Changing Operators and Instruments on Time-Domain and Spectral-Domain OCT Measurements of Retinal Nerve Fiber Layer Thickness

      Effects of Changing Operators and Instruments on Time-Domain and Spectral-Domain OCT Measurements of Retinal Nerve Fiber Layer Thickness
      BACKGROUND AND OBJECTIVE: To determine the amount of interoperator and interinstrument variability introduced into retinal nerve fiber layer (RNFL) thickness measured with Stratus OCT and Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) in normal and glaucomatous eyes. PATIENTS AND METHODS: Thirty-seven eyes from 37 subjects (20 normal and 17 with glaucoma) were included in the study. Each eye was scanned with one Stratus OCT and one Cirrus OCT by two operators. The eyes were then scanned with a different Stratus OCT and Cirrus OCT by one of the operators. Average, quadrant, and clock-hour RNFL measurements were compared between operators and ...
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    19. Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography

      Purpose: To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD).Design: Prospective, longitudinal, natural history study.Participants: We included 143 eyes of 100 patients with at least 6 months of follow-up.Methods: Patients with drusen secondary to nonexudative AMD were scanned using the Cirrus SD-OCT instrument. Eyes were imaged using the 200×200 A-scan raster pattern contained within a 6×6 mm area. Custom software was used to quantify volumetric changes in drusen over a period of ≥6 months and for as long as 24 ...

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    20. Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography

      Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography
      Purpose.To compare choroidal thickness measurements among normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters. Methods.Choroidal thickness was measured with enhanced depth-imaging (EDI) optical coherence tomography (OCT) in one eye of 38 normal, 20 NTG, and 56 POAG subjects and compared among groups. The mean age was 69.3 ± 13.6 years (60.1 ± 13.4 years for normal subjects and 73.8 ± 11.3 years for glaucoma subjects; P < 0.001). Measurements were made at the fovea and in the ...
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    21. Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration

      Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration
      Purpose: To measure drusen area and volume in eyes with nonexudative age-related macular degeneration (AMD) using spectral domain optical coherence tomography imaging (SD-OCT). Design: Evaluation of diagnostic technology. Participants: One hundred three eyes from 74 patients with drusen. Methods: Patients with drusen secondary to nonexudative AMD were enrolled in this study. Five separate SD-OCT scans, each consisting of 40 000 uniformly spaced A-scans organized as 200 A-scans in each B-scan and 200 horizontal B-scans, were performed on each eye. Each scan covered a retinal area of 6 × 6 mm centered on the fovea. A novel algorithm was used to quantitatively ...
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    22. Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth Imaging Optical Coherence Tomography

      Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth Imaging Optical Coherence Tomography
      Purpose. To compare choroidal thickness measurements between normal eyes, eyes with normal tension glaucoma (NTG), and those with primary open-angle glaucoma (POAG), and to correlate choroidal thickness with demographic and clinical ocular parameters. Methods. Choroidal thickness was measured with enhanced depth imaging (EDI) optical coherence tomography (OCT) using Spectralis OCT in one eye of 38 normal, 20 NTG and 56 POAG subjects and compared between groups. The mean age was 69.3 ± 13.6 years (60.1 ± 13.4 years for normal and 73.8 ± 11.3 years for glaucoma subjects, P < 0.001). Measurements were made at the fovea ...
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    23. Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure

      Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure
      BACKGROUND AND OBJECTIVE The purpose of this study was to examine the hypothesis that retinal nerve fiber layer (RNFL) birefringence increases following surgical reduction of intraocular pressure (IOP). PATIENTS AND METHODS Twenty-six glaucomatous eyes requiring trabeculectomy or drainage implant were enrolled. Optical coherence tomography (OCT), scanning laser polarimetry (SLP), and IOP measurements were performed preoperatively and 3 months postoperatively. The OCT and SLP images were aligned using a new algorithm that aligns the vessels in an OCT image to those in the corresponding SLP reflectance image. The SLP retardance values at the location of the OCT scan circle were then ...
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    24. Progression of Geographic Atrophy in Age-Related Macular Degeneration Imaged with Spectral Domain Optical Coherence Tomography

      Progression of Geographic Atrophy in Age-Related Macular Degeneration Imaged with Spectral Domain Optical Coherence Tomography
      Purpose:: To determine the area and enlargement rate (ER) of geographic atrophy (GA) in patients with age-related macular degeneration (AMD) using the spectral domain optical coherence tomography (SD-OCT) fundus image.Design:: Prospective, longitudinal, natural history study.Participants:: Eighty-six eyes of 64 patients with ≥6 months of follow-up.Methods:: Patients with GA secondary to AMD were enrolled in this study. Macular scans were performed using the Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA). The areas of GA identified on the SD-OCT fundus images were quantified using a digitizing tablet. Reproducibility of these measurements was assessed and the ER of GA was ...
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    Topographic Differences in the Age-related Changes in the Retinal Nerve Fiber Layer of Normal Eyes Measured by Stratus Optical Coherence Tomography Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters Measured with Cirrus HD-OCT in Glaucomatous Eyes Progression of Geographic Atrophy in Age-Related Macular Degeneration Imaged with Spectral Domain Optical Coherence Tomography Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration Natural History of Drusen Morphology in Age-Related Macular Degeneration Using Spectral Domain Optical Coherence Tomography Macular Ganglion Cell-Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral-Domain Optical Coherence Tomography in Glaucoma Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study