All Articles from xuan liu -Optical Coherence Tomography News

Articles from xuan liu

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1. Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images
  
  Explore OSA | OSA Publishing Apr 13 2021 Oncology
  
  In this study, we performed dual-modality optical coherence tomography (OCT) characterization (volumetric OCT imaging and quantitative optical coherence elastography) on human breast tissue specimens. We trained and validated a U-Net for automatic image segmentation. Our results demonstrated that U-Net segmentation can be used to assist clinical diagnosis for breast cancer, and is a powerful enabling tool to advance our understanding of the characteristics for breast tissue. Based on the results obtained from U-Net segmentation of 3D OCT images, we demonstrated significant morphological heterogeneity in small breast specimens acquired through diagnostic biopsy. We also found that breast specimens affected by different ...
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2. Line field Fourier domain optical coherence tomography based on a spatial light modulator
  
  Explore OSA | OSA Publishing Jan 27 2021
  
  In this study, we developed a line-field Fourier domain optical coherence tomography (LF-FDOCT) system that performs lateral scanning using a two-dimension spatial light modulator and detects multiple channels of spectral domain OCT signal in parallel using a two-dimensional sensor. The LF-FDOCT system eliminates the need for mechanical scanning to acquire volumetric OCT data. It allows parallel acquisition of signal for B mode scan imaging through snapshot detection and offers unprecedented flexibility to select a fast scanning dimension. In this work, we describe the principle of LF-FDOCT imaging and present experimental results to demonstrate the effectiveness of this technology.
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3. Spectral 3D reconstruction of impressionist oil paintings based on macroscopic OCT imaging
  
  Explore OSA | OSA Publishing May 20 2020 Art
  
  Art conservators have adopted optical technologies to improve conservation efforts; laser triangulation, stereophotogrammetry, structured light, laser scanners, and time of flight sensors have been deployed to capture the 3D information of sculptures and architectures. Optical coherence tomography (OCT) has introduced new imaging methods to study the surface features and subsurface structures of delicate cultural heritage objects. However, the field of view of OCT severely limits the scanning area. We present a hybrid scanning platform combined with an effective algorithm for real-time sampling and artifact removal to achieve macroscopic OCT (macro-OCT) imaging and spectral 3D reconstruction of impressionist style oil paintings.
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4. Optically computed optical coherence tomography for volumetric imaging
  
  Explore OSA | OSA Publishing Mar 31 2020
  
  We describe an innovative optically computed optical coherence tomography (OC-OCT) technology. The OC-OCT system performs depth resolved imaging by computing the Fourier transform of the interferometric spectra optically. The OC-OCT system modulates the interferometric spectra with Fourier basis function projected to a spatial light modulator and detects the modulated signal without spectral discrimination. The novel, to the best of our knowledge, optical computation strategy enables volumetric OCT imaging without performing mechanical scanning and without the need for Fourier transform in a computer.
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5. Spatial coordinate corrected motion tracking for optical coherence elastography
  
  Explore OSA | OSA Publishing Nov 10 2019
  
  We investigate a spatial coordinate correction (SCC) method to track motion with high accuracy for optical coherence elastography (OCE). Through SCC, we refer the displacement field tracked by optical coherence tomography (OCT) in the loaded sample to individual material points defined in a fixed coordinate system. SCC allows OCE to perform spatially and temporally unambiguous tracking of displacement and enables accurate mechanical characterization of biological tissue for cancer diagnosis and tumor margin assessment. In this study, we validated the effectiveness of motion tracking based on SCC using experimental OCE data obtained from ex vivo human breast tissues.
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6. Assessment and removal of additive noise in a complex optical coherence tomography signal based on Doppler variation analysis
  
  Explore OSA | OSA Publishing Apr 4 2018
  
  In this study, we investigate and validate a novel approach to assess and remove additive noise for optical coherence tomography (OCT) imaging. Our method first generates a map of additive noise for the OCT image through Doppler variation analysis. We then remove the additive noise from the real and imaginary parts of the complex OCT signal through pixelwise Wiener filtering. Our results show that the method described in this manuscript improves the sensitivity of OCT imaging and preserves the spatial resolution without the need to modify the imaging apparatus and data acquisition protocol.
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7. Noise adaptive wavelet thresholding for speckle noise removal in optical coherence tomography
  
  Explore OSA | OSA Publishing May 2 2017
  
  Optical coherence tomography (OCT) is based on coherence detection of interferometric signals and hence inevitably suffers from speckle noise. To remove speckle noise in OCT images, wavelet domain thresholding has demonstrated significant advantages in suppressing noise magnitude while preserving image sharpness. However, speckle noise in OCT images has different characteristics in different spatial scales, which has not been considered in previous applications of wavelet domain thresholding. In this study, we demonstrate a noise adaptive wavelet thresholding (NAWT) algorithm that exploits the difference of noise characteristics in different wavelet sub-bands. The algorithm is simple, fast, effective and is closely related to ...
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  Mentions: Harvard University
8. Secure fingerprint identification based on structural and microangiographic optical coherence tomography
  
  Explore OSA | OSA Publishing Mar 6 2017 Dermatology , NDE/NDT , Other Non-Medical
  
  Optical coherence tomography (OCT) allows noncontact acquisition of fingerprints and hence is a highly promising technology in the field of biometrics. OCT can be used to acquire both structural and microangiographic images of fingerprints. Microangiographic OCT derives its contrast from the blood flow in the vasculature of viable skin tissue, and microangiographic fingerprint imaging is inherently immune to fake fingerprint attack. Therefore, dual-modality (structural and microangiographic) OCT imaging of fingerprints will enable more secure acquisition of biometric data, which has not been investigated before. Our study on fingerprint identification based on structural and microangiographic OCT imaging is, we believe, highly ...
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9. Optical coherence tomography for non-invasive examination and conservation of cultural heritage objects
  
  Explore Conference Proceedings Mar 1 2017 Art
  
  Optical coherence tomography (OCT) has great potential for the examination of oil paintings, particularly for celebrated masterpieces by great artists in history. We developed an OCT system for large field of view (FOV), high definition (HD) imaging of oil paintings. To achieve large FOV, we translated the sample using a pair of high-precision linear motors and performed sequential volumetric imaging on adjacent, non-overlapping regions. Through 3D OCT imaging, the surface terrain and subsurface microarchitecture of the paintings have been characterized and visualized.
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  Mentions: Boston University
10. High-definition optical coherence tomography imaging for noninvasive examination of heritage works
  
  Explore OSA | OSA Publishing Dec 14 2016 Art
  
  Cultural heritage works, such as ancient murals and historical paintings, are examined routinely for the purpose of conservation. Previous works have applied optical coherence tomography (OCT), which is a three-dimensional (3D) microscopic imaging modality in the field of heritage works conservation. The data acquired by OCT provides both 3D surface information of the object and structure information underneath the surface. Therefore, cross-sectional information on the object can be utilized to study layer structure of the painting and brush stroke techniques used by the artist. However, as demonstrated in previous studies, OCT has limited capability in high-definition (HD) examination of paintings ...
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  Mentions: Boston University
11. Optical coherence tomography systems and methods with magnitude and direction tracking of transverse motion
  
  Explore uspto.gov Nov 29 2016 Ophthalmology , Patents
  
  An optical coherence tomography (OCT) system having magnitude and direction of motion detection has a light source, and a scanning system arranged in an optical path of the light source. The scanning system is configured to scan an illumination beam of light in a spatial pattern around each of a plurality of points of interest of an object under observation for a corresponding plurality of instants of time in which each of the plurality of points of interest are displaced from each other due to motion of at least one of the OCT system or the object under observation. The ...
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  Mentions: Johns Hopkins University
12. Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties
  
  Explore OSA | OSA Publishing Jan 28 2016
  
  We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus ...
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13. Lateral distortion corrected optical coherence tomography system
  
  Explore uspto.gov Jan 26 2016 Patents
  
  A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement ...
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  Mentions: Johns Hopkins University
14. Interferometric force sensor for surgical instruments
  
  Explore uspto.gov Jan 26 2016 Patents , Probes
  
  A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or ...
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  Mentions: Johns Hopkins University
15. Robust motion tracking based on adaptive speckle decorrelation analysis of OCT signal
  
  Explore OSA | OSA Publishing Nov 29 2015
  
  Speckle decorrelation analysis of optical coherence tomography (OCT) signal has been used in motion tracking. In our previous study, we demonstrated that cross-correlation coefficient (XCC) between Ascans had an explicit functional dependency on the magnitude of lateral displacement ( δx ). In this study, we evaluated the sensitivity of speckle motion tracking using the derivative of function XCC( δx ) on variable δx . We demonstrated the magnitude of the derivative can be maximized. In other words, the sensitivity of OCT speckle tracking can be optimized by using signals with appropriate amount of decorrelation for XCC calculation. Based on this finding, we developed an ...
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16. Motion analysis and removal in intensity variation based OCT angiography
  
  Explore opticsinfobase.org Oct 7 2014
  
  In this work, we investigated how bulk motion degraded the quality of optical coherence tomography (OCT) angiography that was obtained through calculating interframe signal variation, i.e., interframe signal variation based optical coherence angiography (isvOCA). We demonstrated theoretically and experimentally that the spatial average of isvOCA signal had an explicit functional dependency on bulk motion. Our result suggested that the bulk motion could lead to an increased background in angiography image. Based on our motion analysis, we proposed to reduce image artifact induced by transient bulk motion in isvOCA through adaptive thresholding. The motion artifact reduced angiography was demonstrated in ...
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17. Durable Single Mode Fiber Probe With Optimized Reference Reflectivity
  
  Explore patentscope.wipo.int Jun 12 2014 Patents , Probes
  
  A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the ...
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  Mentions: Johns Hopkins University
18. Distortion Corrected Optical Coherence Tomography System
  
  Explore patentscope.wipo.int Jun 12 2014 Patents
  
  An axial motion distortion-corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to receive said detection signals, construct a plurality of A-scans from said detection signals, and construct one or more images from said plurality of A-scans. The data processing system can be configured to correct distortion in the images caused ...
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  Mentions: Johns Hopkins University
19. Postdoctoral Fellow Opening in Electrical and Computer Engineering Department at New Jersey Institute of Technology
  
  Explore Optical Coherence Tomography News May 13 2014 Jobs & Studentships
  
  A postdoc position in biomedical optics is available at Electrical and Computer Engineering Department at New Jersey Institute of Technology. The successful candidate will work on highly innovative projects focused on the development of miniature optical coherence tomography (OCT) device for imaging and functional information extraction. Requirements: A doctorate degree in Optics, Physics, Biomedical Engineering, Electrical Engineering, or related fields is required. It is desirable to be experienced in one or more of the following areas: fiber optics; design and alignment of optical imaging system; microscopy; signal processing; programming in C/C++/Matlab/Labview. Expertise of OCT is preferred but ...
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20. Improvement of optical coherence tomography using active handheld micromanipulator in vitreoretinal surgery
  
  Explore IEEE Xplore Oct 12 2013 Probes
  
  An active handheld micromanipulator has been developed to cancel hand tremor during microsurgery. The micromanipulator is also applicable in optical coherence tomography to improve the quality of scanning and minimize surgical risks during the scans. The manipulator can maneuver the tool tip with six degrees of freedom within a cylindrical workspace 4 mm in diameter and 4 mm high. The imaging system is equipped with a 25-gauge Fourier-domain common-path OCT probe. This paper introduces the handheld OCT imaging system and techniques involved and presents stabilized OCT images of A-mode and M-mode scans in air and live rabbit eyes. We show ...
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  Mentions: Johns Hopkins University Carnegie Mellon University
21. Optimization of an angled fiber probe for common-path optical coherence tomography
  
  Explore opticsinfobase.org Jul 18 2013 Probes
  
  We studied the optimization of common-path optical coherence tomography (CP OCT) sensitivity through an angled fiber probe. The magnitude of reference power derived from the tip of the fiber was optimized through careful selection of the polishing angle. We experimentally measured the signal-to-noise ratio (SNR) at different polishing angles to validate the effectiveness of this technique. We also obtained OCT images with the reference optimized CP OCT with more than 8 dB improvement in SNR.
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  Mentions: Johns Hopkins University
22. Lateral Distortion Corrected Optical Coherence Tomography System
  
  Explore patentscope.wipo.int Jul 1 2013 Patents
  
  A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement ...
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  Mentions: Johns Hopkins University
23. Quantitative transverse flow measurement using optical coherence tomography speckle decorrelation analysis
  
  Explore opticsinfobase.org Mar 1 2013
  
  We propose an inter-Ascan speckle decorrelation based method that can quantitatively assess blood flow normal to the direction of the optical coherence tomography imaging beam. To validate this method, we performed a systematic study using both phantom and in vivo animal models. Results show that our speckle analysis method can accurately extract transverse flow speed with high spatial and temporal resolution.
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  Mentions: Johns Hopkins University
24. Robust spectral-domain optical coherence tomography speckle model and its cross-correlation coefficient analysis
  
  Explore opticsinfobase.org Dec 10 2012
  
  In this study, we propose a generic speckle simulation for optical coherence tomography (OCT) signal, by convolving the point-spread function (PSF) of the OCT system with the numerically synthesized random sample field. We validate our model and use the simulation method to study the statistical properties of cross-correlation coefficients between A-scans, which have been recently applied in transverse motion analysis by our group. The results of simulation show that oversampling is essential for accurate motion tracking; exponential decay of OCT signal leads to an underestimate of motion that can be corrected; lateral heterogeneity of sample leads to an overestimate of ...
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  Mentions: Johns Hopkins University
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