1. Articles from Axel Petzold

    25-28 of 28 « 1 2
    1. A Simple Sign for Recognizing Off–Axis OCT Measurement Beam Placement in the Context of Multicentre Studies

      A Simple Sign for Recognizing Off–Axis OCT Measurement Beam Placement in the Context of Multicentre Studies

      Purpose Optical coherence tomography (OCT) allows quantification of the thickness of the retinal nerve fibre layer (RNFL) thickness, a potential biomarker for neurodegeneration. The estimated annual RNFL loss in multiple sclerosis amounts to 2 μ m using time domain OCT. The recognition of measurement artifacts exceeding this limit is relevant for the successful use of OCT as a secondary outcome measure in clinical trials. Methods Prospective study design. An exploratory pilot study (ring and volume scans) followed by a cohort study (1,980 OCT ring scans). The OCT measurement beam was placed off–axis to the left, right, top and bottom ...

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    2. The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment

      Background Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria to a training set of 101 retinal OCT scans from patients with MS; (3) kappa statistics for inter-rater agreement; (4) identification reasons for inter-rater disagreement; (5) development of new consensus ...

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    3. The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography

      The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography

      Purpose. With the introduction of spectral domain–optical coherence tomography (SD-OCT), changes in retinal nerve fiber layer (RNFL) thickness and macular volume (MV) can be detected with high precision. The aim of this study was to determine whether there is a physiological quantifiable degree of variation of these structures in humans. Methods. This study took place during a 10-km charity run at VU University Medical Center Amsterdam. Weight, height, hydration status, RNFL thickness (ring scan, 12° around the optic nerve head), and MV (20° × 20°) were assessed in 69 subjects (44 runners, 25 controls) using SD-OCT with eye-tracking function. The ...

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    4. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91—22·86, n=2063, p<0·0001) after optic neuritis in MS, and of 7·08 μm (5·52—8·65, n=3154, p<0·0001) in MS without optic neuritis. The estimated RNFL thinning in patients with MS is greater than the extent expected in normal ageing, probably because of retrograde trans-synaptic degeneration ...

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    25-28 of 28 « 1 2
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  2. Topics in the News

    1. (28 articles) Axel Petzold
    2. (14 articles) University College London
    3. (13 articles) VU University Amsterdam
    4. (9 articles) Friedemann Paul
    5. (7 articles) Johns Hopkins University
    6. (7 articles) Peter A. Calabresi
    7. (6 articles) UCSF
    8. (6 articles) Laura J. Balcer
    9. (6 articles) Fiona E. Costello
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    Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment A Simple Sign for Recognizing Off–Axis OCT Measurement Beam Placement in the Context of Multicentre Studies Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported Optical Coherence Tomography Reveals Distinct Patterns of Retinal Damage in Neuromyelitis Optica and Multiple Sclerosis The investigation of acute optic neuritis: a review and proposed protocol Re: Garcia-Martin et al.: Retinal layer segmentation in patients with multiple sclerosis using spectral domain optical coherence tomography Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank Diagnostic Performance of Deep Learning for Angle Closre Wide-field Optical Coherence Tomography Imaging of Excised Breast Tissue.