1. Articles from Randy Kardon

    1-5 of 5
    1. Optical Coherence Tomography in Papilledema: What Am I Missing?

      Optical Coherence Tomography in Papilledema: What Am I Missing?

      Background: Grading of papilledema severity is subjective and based on monocular fundus features of the optic nerve. Interobserver agreement on grading the severity of papilledema is poor among expert observers, even using well-defined criteria such as the Frisen scale, which is a non-continuous ordinal scale of grading. Furthermore, non-expert clinicians often find it difficult to properly view and interpret features of the optic nerve using ophthalmoscopy, which can lead to failure to diagnose papilledema in non-ophthalmologic care settings. This may delay treatment, which can result in vision loss. Distinguishing papilledema from pseudopapilledema can also be difficult when surface drusen are ...

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    2. A combined machine-learning and graph-based framework for the segmentation of retinal surfaces in SD-OCT volumes

      A combined machine-learning and graph-based framework for the segmentation of retinal surfaces in SD-OCT volumes

      Optical coherence tomography is routinely used clinically for the detection and management of ocular diseases as well as in research where the studies may involve animals. This routine use requires that the developed automated segmentation methods not only be accurate and reliable, but also be adaptable to meet new requirements. We have previously proposed the use of a graph-theoretic approach for the automated 3-D segmentation of multiple retinal surfaces in volumetric human SD-OCT scans. The method ensures the global optimality of the set of surfaces with respect to a cost function. Cost functions have thus far been typically designed by ...

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    3. Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Purpose. Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by optical coherence tomography (OCT), in nonarteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. Methods. We prospectively performed automated perimetry, SLP, and high definition OCT (HD-OCT) of the RNFL in 25 eyes with acute NAION. We grouped visual field threshold and RNFL values into Garway-Heath inferior/superior disc sectors and corresponding superior/inferior field regions. We compared sector SLP ...

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    4. Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis

      Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis

      Optic neuritis (ON) is an inflammatory optic nerve injury, which is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) has the potential to provide a reliable means of capturing axonal deficits, which can be paired to tests of visual function to provide a structural–functional paradigm of brain injury. In this respect, the eye provides a unique view into the effects of central nervous system inflammation, which may enhance the understanding of disease mechanisms that contribute to neurological disability in MS. This review addresses the published experience with OCT in the diagnosis and treatment of patients with ON ...

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    5. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

      Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91—22·86, n=2063, p<0·0001) after optic neuritis in MS, and of 7·08 μm (5·52—8·65, n=3154, p<0·0001) in MS without optic neuritis. The estimated RNFL thinning in patients with MS is greater than the extent expected in normal ageing, probably because of retrograde trans-synaptic degeneration ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Randy H. Kardon
    2. (4 articles) University of Iowa
    3. (1 articles) Johns Hopkins University
    4. (1 articles) VU University Amsterdam
    5. (1 articles) Duke University
    6. (1 articles) Peter A. Calabresi
    7. (1 articles) Johannes F. de Boer
    8. (1 articles) Mona K. Garvin
    9. (1 articles) Young H. Kwon
    10. (1 articles) Michael D. Abràmoff
    11. (1 articles) University of Melbourne
    12. (1 articles) Dresden University of Technology
    13. (1 articles) University of Washington
    14. (1 articles) University of Bonn
    15. (1 articles) Ruikang K. Wang
    16. (1 articles) Julia Walther
    17. (1 articles) Frank G. Holz
    18. (1 articles) Edmund Koch
    19. (1 articles) Steffen Schmitz-Valckenberg
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    Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis Optical Coherence Tomography in the Diagnosis and Management of Optic Neuritis and Multiple Sclerosis Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy A combined machine-learning and graph-based framework for the segmentation of retinal surfaces in SD-OCT volumes Optical Coherence Tomography in Papilledema: What Am I Missing? Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-related Central and Peripheral Hearing Loss in a Southern Italian Older Population Optical coherence tomography outcomes from SPRINT-MS, a multicenter, randomized, double-blind trial of ibudilast in progressive multiple sclerosis Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis