1. Articles from Jeremy A. Guggenheim

    1-5 of 5
    1. Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography

      Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography

      Dispersion encoded full-range (DEFR) frequency-domain optical coherence tomography (FD-OCT) and its enhanced version, fast DEFR, utilize dispersion mismatch between sample and reference arm to eliminate the ambiguity in OCT signals caused by non-complex valued spectral measurement, thereby numerically doubling the usable information content. By iteratively suppressing asymmetrically dispersed complex conjugate artifacts of OCT-signal pulses the complex valued signal can be recovered without additional measurements, thus doubling the spatial signal range to cover the full positive and negative sampling range. Previously the computational complexity and low processing speed limited application of DEFR to smaller amounts of data and did not allow ...

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    2. Graphics processing unit based dispersion encoded full-range frequency domain OCT

      Graphics processing unit based dispersion encoded full-range frequency domain OCT

      Standard FD-OCT systems suffer from a limited useful depth range due to the inherent complex conjugate artifacts and continuous fall-off in sensitivity with distance from the zero delay. The techniques of dispersion encoded full range (DEFR) frequency-domain optical coherence tomography (FD-OCT) and its enhanced version fast DEFR use the dispersion mismatch between sample and reference arm to double the imaging depth range by iteratively suppressing complex conjugate artifacts. Previously the computational complexity of DEFR prevented its application to fields where real-time visualization or large volumetric datasets are needed. A graphics processing unit (GPU) with hundreds of processing cores provides highly ...

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    3. Feature Of The Week 10/2/11: Heritability of Ocular Component Dimensions in Mice Phenotyped using Depth-Enhanced SS-OCT

      Feature Of The Week 10/2/11: Heritability of Ocular Component Dimensions in Mice Phenotyped using Depth-Enhanced SS-OCT
      Researchers based at Cardiff University and the Medical University of Vienna have taken advantage of the extended depth range delivered by swept source OCT to measure the eye size of mice with unprecedented precision [1].Measurement of eye size in humans is a standard medical procedure carried out before cataract removal surgery, which is perhaps the most commonly performed surgical operation in the world. The eye measurements are acquired using a laser Doppler interferometry (LDI) technique [2] closely related to time domain OCT.The length of the eye along its visual axis determines the refractive error of the eye. Myopia ...
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    4. Heritability of ocular component dimensions in mice phenotyped using depth-enhanced swept source optical coherence tomography

      Heritability of ocular component dimensions in mice phenotyped using depth-enhanced swept source optical coherence tomography
      The range of genetic and genomic resources available makes the mouse a powerful model for the genetic dissection of complex traits. Because accurate, high-throughput phenotypic characterisation is crucial to the success of such endeavours, we recently developed an optical coherence tomography (OCT) system with extended depth range scanning capability for measuring ocular component dimensions in mice. In order to test whether the accuracy and reproducibility of our OCT system was sufficient for gene mapping studies, we carried out an experiment designed to estimate the heritability of mouse ocular component dimensions. High-resolution, two dimensional tomograms were obtained for both eyes of ...
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    5. Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye

      Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye
      We report a high-speed, dispersion-encoded, full-range (DEFR) swept-source optical coherence tomography system for in vivo ocular imaging and biometry of small animals. The fast DEFR algorithm removes the depth ambiguity, gives access to objects located at the zero delay position, and doubles the sampling depth to 2×5.0 mm (at −101 to −71 dB sensitivity) in a single scan using 2048 samples/depth scan 0.43 nm line width of a light source operating at 1056 nm with 70 nm tuning range. The acquisition speed (frames of 512 depth scans in 18.3 ms) permits precise on-line monitoring during ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Cardiff University
    2. (5 articles) Medical University of Vienna
    3. (2 articles) Chang Gung University
    4. (2 articles) Boston University
    5. (2 articles) Massachusetts General Hospital
    6. (1 articles) K. U. Leuven
    7. (1 articles) Santec
    8. (1 articles) Harvard University
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    Highly reproducible swept-source, dispersion-encoded full-range biometry and imaging of the mouse eye Heritability of ocular component dimensions in mice phenotyped using depth-enhanced swept source optical coherence tomography Feature Of The Week 10/2/11: Heritability of Ocular Component Dimensions in Mice Phenotyped using Depth-Enhanced SS-OCT Graphics processing unit based dispersion encoded full-range frequency domain OCT Graphics processing unit-based dispersion encoded full-range frequency-domain optical coherence tomography A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography Depth of focus extension in optical coherence tomography using ultrahigh chromatic dispersion of zinc selenide Retinal changes in bipolar disorder as an endophenotype candidate: Comparison of OCT-detected retinal changes in patients, siblings, and healthy controls Intraoperative optical coherence tomography guided 25G micro-amount trajectory vitrectomy for the treatment of penetrating ocular injury caused by a foreign body in the right eye: A case study Optical coherence tomography angiography reveals paradoxically decreasing choroidal thickness & increasing blood flow in remitting Vogt Koyanagi Harada syndrome A comparison of macular ganglion cell and retinal nerve fibre layer optical coherence tomographic parameters as predictors of visual outcomes of surgery for pituitary tumours