1. Articles from A. Karanasos

    1-5 of 5
    1. Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography.

      Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography.

      Despite significant advances in preventive, medical and interventional management, coronary artery disease remains the leading cause of death worldwide. We now know that in the majority of acute coronary syndromes, a thrombotic event is triggered either by the rupture or erosion of the so-called high-risk or ‘vulnerable’ plaque. However, accurately identifying the individual who is at significant risk of acute event remains the holy grail of preventive cardiology. To better stratify an individual’s risk of developing and suffering a cardiovascular event, biomarkers are needed that can accurately predict coronary events, and if possible monitor disease activity in response to ...

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    2. Visualization of extensive intraplaque neovascularization by optical coherence tomography

      Visualization of extensive intraplaque neovascularization by optical coherence tomography

      Inflammation plays a key role in pathogenesis and progression of atherosclerosis (1) . Advent of novel intravascular imaging tools such as Optical Coherence Tomography (OCT) has led to visualization of coronary atherosclerotic plaque characteristics in vivo that were previously seen only on histology. Herein we discuss a case of extensive neovascularization, a feature that imparts vulnerability to atherosclerotic plaque in the coronary artery, as seen by two- and three-dimensional OCT images. A 63-year-old female with history of diabetes mellitus and hypertension presented with troponin-positive chest pain. She underwent coronary angiography followed by drug-eluting stent implantation to the mid segment of right ...

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    3. OCT demonstrating neoatherosclerosis as part of the continuous process of coronary artery disease

      OCT demonstrating neoatherosclerosis as part of the continuous process of coronary artery disease

      Although the advent of drug-eluting stents has reduced the rates of target vessel revascularization, there are observations of ongoing stent failure occurring very late after stent implantation and presenting as very late restenosis or as very late stent thrombosis. The de novo development of atherosclerosis within the neointimal region, called neoatherosclerosis, has been identified as one of the pathomechanisms of these observed late stent failures. The mechanisms of neoatherosclerosis development and its association with stent failure are currently the subject of intensive research. Optical coherence tomography (OCT) is an invasive imaging modality that allows us to visualize the micromorphology of ...

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    4. The impact of Fourier-Domain optical coherence tomography catheter induced motion artefacts on quantitative measurements of a PLLA-based bioresorbable scaffold

      The impact of Fourier-Domain optical coherence tomography catheter induced motion artefacts on quantitative measurements of a PLLA-based bioresorbable scaffold

      Intracoronary Fourier-Domain optical coherence tomography (FD-OCT) enables imaging of the coronary artery within 2-4 seconds, a so far unparalleled speed. Despite such fast data acquisition, cardiac and respiratory motion can cause artefacts due to longitudinal displacement of the catheter within the artery. We studied the influence of longitudinal FD-OCT catheter displacement on serial global lumen and scaffold area measurements in coronary arteries of swine that received PLLA-based bioresorbable scaffolds. In 10 swine, 20 scaffolds (18 × 3.0 mm) were randomly implanted in two epicardial coronary arteries. Serial FD-OCT imaging was performed immediately after implantation (T1) and at 3 (T2) and ...

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    5. Multiple plaque morphologies assessed by optical coherence tomography in a patient with acute coronary syndrome

      Multiple plaque morphologies assessed by optical coherence tomography in a patient with acute coronary syndrome

      A 64-year-old male patient presented at the emergency department with chest pain. ST-segment depression (1 mm) was present in leads V4–V6, and cardiac troponin was elevated (10.4 ng/ml). He was treated medically, and he did not have any chest pain thereafter. We performed coronary angiography 60 h later, which revealed a proximal lesion in the left circumflex artery with a

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    1-5 of 5
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  2. Topics in the News

    1. (4 articles) Erasmus University
    2. (4 articles) Antonios Karanasos
    3. (4 articles) Evelyn Regar
    4. (1 articles) University College London
    5. (1 articles) Geert Springeling
    6. (1 articles) Heleen M. M. Van Beusekom
    7. (1 articles) Jurgen M. Ligthart
    8. (1 articles) Hector M. Garcia-Garcia
    9. (1 articles) Nico Bruining
    10. (1 articles) Karen T. Witberg
    11. (1 articles) Academic Medical Center at the University of Amsterdam
    12. (1 articles) Nankai University
    13. (1 articles) University of Illinois at Urbana-Champaign
    14. (1 articles) The Ohio State University
    15. (1 articles) Daniël M. de Bruin
    16. (1 articles) Dirk J. Faber
    17. (1 articles) Ton G. van Leeuwen
    18. (1 articles) Yanmei Liang
    19. (1 articles) Stephen A. Boppart
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    Multiple plaque morphologies assessed by optical coherence tomography in a patient with acute coronary syndrome The impact of Fourier-Domain optical coherence tomography catheter induced motion artefacts on quantitative measurements of a PLLA-based bioresorbable scaffold OCT demonstrating neoatherosclerosis as part of the continuous process of coronary artery disease Visualization of extensive intraplaque neovascularization by optical coherence tomography Association of systemic inflammatory biomarkers with morphological characteristics of the coronary atherosclerotic plaque by intravascular optical coherence tomography. High-resolution polarization-sensitive optical coherence tomography for zebrafish muscle imaging Very Late Stent Thrombosis 89 Months after Implantation of Durable Polymer Everolimus-Eluting Stent due to Late Acquired Stent Malapposition and Uncovered Struts Observed by Optical Coherence Tomography, Near-Infrared Spectroscopy and Coronary Angioscopy Optical Coherence Tomography Angiography Analysis of Retinal and Choroidal Vascular Networks during Acute, Relapsing, and Quiescent Stages of Macular Toxoplasma Retinochoroiditis 3D co-registration algorithm for catheter-based optical coherence tomography The feasibility and utility of optical coherence tomography directed histopathology for surgical margin assessment of canine mast cell tumors Woven Coronary Artery Anomaly: Optical Coherence Tomography Versus Intravascular Ultrasound Optical microangiography reveals temporal and depth-resolved hemodynamic change in mouse barrel cortex during whisker stimulation